A5025290189- Adipose Tissue and Metabolism
- Veterinary Pharmacology and Anesthesia
- Adipokines, Inflammation, and Metabolic Diseases
- Veterinary Equine Medical Research
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Veterinary Oncology Research
- Muscle metabolism and nutrition
- Insect and Pesticide Research
- Vitamin D Research Studies
- Ocular Infections and Treatments
- Vitamin C and Antioxidants Research
- Intraocular Surgery and Lenses
- Diet and metabolism studies
- Exercise and Physiological Responses
- Apelin-related biomedical research
- Intramuscular injections and effects
- Clinical Laboratory Practices and Quality Control
- Tendon Structure and Treatment
- Veterinary Medicine and Surgery
- Insect Resistance and Genetics
- Plant Surface Properties and Treatments
- Orthopedic Surgery and Rehabilitation
- Irrigation Practices and Water Management
- Antibiotics Pharmacokinetics and Efficacy
University of Tennessee at Knoxville
2016-2025
Simcere Pharmaceutical (China)
2023
Ross University School of Veterinary Medicine
2022
Texas A&M University
2022
Lincoln Memorial University
2022
Union Hospital
2021
Huazhong University of Science and Technology
2021
Tufts University
2018
Texas Tech University
2018
University of California, Davis
2018
The effects of dairy on energy metabolism appear to be mediated, in part, by leucine and calcium which regulate both adipocyte skeletal muscle metabolism. We recently demonstrated that calcitriol fatty acid oxidation cells vitro, with promoting suppressing oxidation. Moreover, coordinately regulated lipid promote flux metabolic flexibility. have now investigated the role mitochondrial biogenesis mediating these effects.We tested effect leucine, regulation mass using a fluorescence method...
Abstract Objective: Obesity is associated with elevated oxidative stress and low‐grade systemic inflammation. We have demonstrated recently that 1α,25‐(OH) 2 ‐D 3 promotes reactive oxygen species production in cultured adipocytes, whereas suppression of by increasing dietary calcium down‐regulates diet‐induced aP2‐agouti transgenic mice. However, whether the anti‐obesity effect plays a role regulation obesity‐associated inflammation not clear. Research Methods Procedures: investigated...
Dietary calcium modulation of adiposity is mediated, in part, by suppression calcitriol, while the additional effect dairy products mediated components; these include high concentration leucine, a key factor regulation muscle protein turnover. We investigated calcitriol and on energy metabolism murine adipocytes cells partitioning between skeletal muscle. Leucine induced marked increase fatty acid oxidation C2C12 (P<0.001) decreased FAS expression 66% 3T3-L1 adipocytes. Calcitriol cell 37%...
We previously found that 1alpha, 25-dihydroxyvitamin D3 [1alpha, 25-(OH)2-D3] modulates adipocyte lipid metabolism via a Ca2+-dependent mechanism and inhibits UCP2 expression, indicating the anti-obesity effects of dietary calcium are mediated by suppression 25-(OH)2-D3 levels. However, because reduces mitochondrial potential, we have evaluated roles UCP2, uncoupling, in apoptosis. Overexpressing 3T3-L1 cells induced marked reductions potential (Deltapsi) ATP production (P<0.01), increases...
To compare the effects of low versus recommended levels dairy intake on weight maintenance and body composition subsequent to loss. Two site (University Kansas-KU; University Tennessee-UT), 9 month, randomized trial. Weight loss was baseline 3 months, 4 months. Participants were maintained randomly assigned (< 1 serving/d) or (> servings/d) diets for phase. Three hundred thirty eight men women, age: 40.3 ± 7.0 years BMI: 34.5 3.1, randomized; Change in (total fat, trunk fat) from months...
Freshwater cyanobacterial blooms are regularly formed by Microcystis spp., which well-known producers of the hepatotoxin microcystin. The environmental factors that regulate microcystin synthesis remain unclear. We used reverse transcription-quantitative PCR (RT-qPCR), metabolomics, and toxin profiling (both LC-MS) to measure response aeruginosa NIES-843 nitrogen (N) concentration, N chemistry (nitrate versus urea), a range seasonally relevant temperatures. Growth rates at lower temperatures...
Abstract BACKGROUND Helicoverpa zea and Spodoptera frugiperda are destructive insect pests of cotton corn. Both have evolved practical resistance to transgenic crops producing Bacillus thuringiensis ( Bt ) toxins in the United States. GS‐omega/kappa‐Hxtx‐Hv1a (ω/κ‐Hv1a) is a novel biopesticide derived from spider venom with activity against lepidopteran pests. The efficacy ω/κ‐Hv1a dependent on combining it facilitator product such as ‐based insecticide. However, unknown if can be an...
We have previously shown 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3] to inhibit mitochondrial uncoupling protein 2 (UCP2) expression in adipocytes and that vivo suppression of calcitriol levels with calcium-rich diets increases UCP2 expression. Because plays a significant role the clearance reactive oxygen species (ROS), we studied effect on ROS production ROS-induced adipocyte proliferation.ROS human murine was stimulated by high glucose (30 mM) or H2O2 (100 nM).Both approaches...
Dietary calcium inhibits adiposity, and a key underlying mechanism is suppression of calcitriol, which modulates Ca<sup>2+</sup> signaling mitochondrial uncoupling in adipocytes. We demonstrated that calcitriol directly regulates adipocyte 11β-HSD-1 expression cortisol production human adipocytes vitro dietary visceral adipose tissue mice, indicating an interaction obesity. Consequently, we have evaluated the gene profile subcutaneous treated with and/or cortisone. Data analysis...
To optimize pesticide applications to the canopies of deciduous perennial crops, spray volume should be adjusted throughout year match changes in canopy and density. Machine-vision, computer-controlled, variable-rate sprayers are now commercially available claim provide adequate coverage with decreased volumes compared constant-rate sprayers. However, there is little research comparing variable- as crop characteristics change a growing season. This study evaluated volume, quality (e.g.,...
Abstract Producing optimal grain yields while reducing adverse environmental impacts of over‐fertilization is essential in intensive, but sustainable, farming systems. We investigated the effects long‐term (1982–2005) application chemical nitrogen (N), N + phosphorus (P) and P potassium (K) on yield, recovery efficiency (NRE) losses two rice–wheat sites subtropical China where pig manure was applied (Suining Wuchang). Four (Suining) or five (Wuchang) treatments were examined: no‐fertilizer,...
Thoracolumbar myelopathy encompasses a number of disease processes such as intervertebral disc disease, discospondylitis, trauma, congenital malformations, neoplasia, and intramedullary spinal cord disease. Compressive herniations are most common in dogs require imaging procedures myelography, computed tomography (CT), and/or magnetic resonance (MRI) to determine the need location for decompressive surgery. The purposes this retrospective, cross-sectional study were evaluate all undergoing...
Periarticular histiocytic sarcoma (PAHS) is the most common synovial tumour in dogs and characterized by aggressive local disease with a high rate of distant metastasis. Previously, an association between PAHS prior joint has been demonstrated Bernese Mountain Dog breed suggested Rottweiler. We hypothesized that this would be present other breeds investigated via retrospective, case-controlled analysis. Cases were diagnosed stifle or elbow. Controls age, sex-matched without diagnosis...
To determine the efficacy and duration of effect for liposomal bupivacaine following perineural administration to medial lateral palmar digital nerves horses.9 nonlame mares.For each horse, 2 mL (13.3 mg/mL; total dose, 53.2 mg or approx 0.11 mg/kg) sterile saline (0.9% NaCl) solution was injected adjacent at level distal aspect proximal sesamoid bones a randomly selected forelimb. Twenty-one days later, opposite treatment administered in contralateral A algometer used measure mechanical...