A5023556785- Veterinary Oncology Research
- Microbial infections and disease research
- Veterinary Orthopedics and Neurology
- Infectious Diseases and Mycology
- Veterinary Equine Medical Research
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Veterinary Medicine and Surgery
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Musculoskeletal synovial abnormalities and treatments
- Rabies epidemiology and control
- Bird parasitology and diseases
- Viral Infections and Vectors
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Tumors and Oncological Cases
- Reproductive Physiology in Livestock
- Immune Response and Inflammation
- Public Administration and Political Analysis
- Veterinary Practice and Education Studies
- Law and Political Science
- Amoebic Infections and Treatments
- Virology and Viral Diseases
University of Tennessee at Knoxville
2015-2024
Knoxville College
2006-2024
Center for Surveillance, Epidemiology, and Laboratory Services
2022
AID Atlanta
2022
Michigan State University
2018
University of Sadat City
2018
Hudson Institute
2016
John Wiley & Sons (United States)
2016
University of Guelph
2012
Covance (United States)
2010
Although synovial cell sarcoma is reported to be the most common neoplasm of canine synovium, this retrospective study 35 tumors found that majority were histiocytic origin. Five (14.3%) sarcomas identified by positive immunohistochemical staining with antibodies cytokeratin. Eighteen (51.4%) morphology and CD18. Six (17.1%) myxomas histologic pattern. The remaining six represented a variety sarcomas, including two malignant fibrous histiocytomas (actin positive), one fibrosarcoma,...
An increased recognition of the role endothelial cells in disease and development methods for cell culture has led to an upsurge inin vitrostudies function. However, most often used these studies do not reflect thein vivoheterogeneity cells. To assess intrinsic differences between large small vessel from different tissues, primary cultures capillaries (brain, lung, adipose tissue) a (aorta) sheep were isolated, purified by fluorescence-activated sorting acetylated low density lipoprotein...
Since the CD40/CD40 ligand (CD40L) interaction is involved in regulation of macrophage production interleukin 12 (IL-12) and T-cell gamma interferon (IFN-gamma), effector cell functions associated with resistance to Toxoplasma gondii, role CD40L immunity this parasite was assessed. Infection C57BL/6 mice T. gondii results an upregulation CD40 expression on accessory populations at local sites infection as well lymphoid tissues. Splenocytes from infected for 5 days produced high levels IL-12...
Abstract The NF-κB family of transcription factors are associated with the regulation innate and adaptive immunity to infection. Infection C57BL/6 mice Toxoplasma gondii resulted in up-regulation activity that included member RelB. To assess role RelB immune response this infection, we challenged RelB-deficient (RelB−/−) wild-type (WT) littermate controls T. gondii. Although WT were resistant gondii, RelB−/− succumbed 10–15 days after Examination accessory cell functions resistance revealed...
To determine whether severity of leukocytosis correlates with postmortem lesions in dogs immune-mediated hemolytic anemia (IMHA).Retrospective study.34 IMHA that had CBC performed within 48 hours prior to death and complete necropsy examinations.Dogs were independently assigned 4 groups (within reference range; mild leukocytosis, moderate marked leukocytosis) 3 lesion (mild lesions, severe lesions).Moderate correlated lesions. Ischemic necrosis liver, kidney, heart, lung, spleen attributable...
After a two-thirds hepatectomy, normally quiescent liver cells are stimulated to reenter the cell cycle and proliferate restore original mass. One of most rapidly highly induced genes proteins in regenerating is insulin-like growth factor binding protein 1 (IGFBP-1), secreted that may modulate activities factors (IGFs) or signal via IGF-independent mechanisms. To assess functional role IGFBP-1 regeneration, mice with targeted disruption gene were generated. Although IGFBP-1(-/-) demonstrated...
A retrospective study of cases a unique intramural inflammatory mass within the feline gastrointestinal tract was performed in order to describe and characterize lesion. Twenty-five were identified from archival surgical postmortem tissues. The lesion most often occurred as an ulcerated at pyloric sphincter (n = 12) or ileocecocolic junction colon 9); remaining small intestine. Seven also had lymph node involvement. lesions characterized by eosinophilic inflammation, large reactive...
Standardization of tumor assessment lays the foundation for validation grading systems, permits reproducibility oncologic studies among investigators, and increases confidence in significance study results. Currently, there is minimal methodological standardization assessing tumors veterinary medicine, with few attempts to validate published protocols schemes. The current article address these shortcomings by providing standard guidelines parameters evaluating specific types. More detailed...
To characterize the clinical, clinicopathologic, and imaging findings in dogs with intestinal lymphangiectasia to compare histologic grade of clinicopathologic abnormalities.Retrospective study.17 a diagnosis lymphangiectasia.Medical records were reviewed for signalment, history, clinical signs, results exploratory laparotomy, radiographic, ultrasonographic, findings.Mean age was 8.3 years; most common signs diarrhea, anorexia, lethargy, vomiting, weight loss. Abnormal physical examination...
Abstract The NF-κB family of transcription factors are involved in the regulation innate and adaptive immune functions associated with resistance to infection. To assess role NF-κB2 cell-mediated immunity, mice deficient gene (NF-κB2−/−) were challenged intracellular parasite Toxoplasma gondii. Resistance this opportunistic pathogen is dependent on production IL-12, which required for development NK cell T responses dominated by IFN-γ necessary control replication parasite. Although...
A free-ranging adult female eastern box turtle (Terrapene carolina carolina) was presented to the University of Tennessee in October 2003 because suspected trauma and blindness. Physical examination revealed lethargy, clear ocular nasal discharges, white oral laryngeal plaques. Intracytoplasmic inclusions within heterophils large mononuclear leukocytes were observed on routine blood smear examination. Postmortem findings included necrosis epithelial parenchymal cells with intracytoplasmic...
Background Echocardiography is used for identification of cardiac tumors and presumptive diagnoses often are made based on the location identified masses. Objectives To determine accuracy echocardiographically when compared with clinicopathologic or histopathologic definitive diagnoses. Animals A total 24 client‐owned dogs having a mass echocardiogram that was subsequently definitively diagnosed by cytology histopathology. Methods Retrospective study. Cardiac Veterinary Database search...
Abstract Objective —To determine which imaging modality best determines the microscopic extent of primary appendicular osteosarcoma in amputated limbs dogs. Design —Case series. Animals —10 dogs with osteosarcoma. Procedure that did not receive neoadjuvent chemotherapy were treated by use limb amputation. Amputated imaged radiography, computed tomography (CT), and magnetic resonance (MRI) examined microscopically to longitudinal neoplastic cell involvement length associated intramedullary...
Four cats with feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) are described. Clinical signs included decreased appetite, weight loss, vomiting and diarrhea. Bloodwork abnormalities mild neutrophilia (n = 2) hyperglobulinemia concurrent hyperproteinemia 2). Ultrasonographically, a total of five solitary masses mural thickening loss layering were identified in the stomach, duodenum, jejunum colon. In one cat second, separate lesion was diagnosed 3 weeks following surgical...
Blastomycosis is a serious fungal disease affecting humans and animals. It typically caused by the thermally dimorphic fungus, Blastomyces dermatitidis. In this report, we describe an infection cryptic species, gilchristii, in tiger (Panthera tigris).
Separation of the femoral capital epiphysis is associated with severe trauma in most species. This report describes 13 cats slipped characterized by a distinctive lesion physeal cartilage. The consists irregular clusters chondrocytes separated abundant matrix on both epiphyseal and metaphyseal side cleavage site. affected population this study 85% male, 90% overweight, 23% Siamese, 4.5-24 months old. histopathology demographics are similar to humans, which often affects overweight adolescent boys.
To describe a series of miniature schnauzers diagnosed with histiocytic sarcoma and assess for possible breed predisposition.Medical records diagnosis between January 2008 April 2015 were reviewed. Data collected included signalment, body weight, presenting complaint, date diagnosis, clinicopathologic diagnostic imaging findings, treatment, therapeutic response, death or last follow-up necropsy findings. Breed predisposition was assessed odds ratios, using breed-matched dogs without admitted...
SUMMARY Cryptosporidium has become increasingly recognized as a pathogen responsible for outbreaks of diarrhoeal illness in both immunocompetent and immunocompromised persons. In August 2001, an Illinois hospital reported cryptosporidiosis cluster potentially linked to local waterpark. There were 358 case-patients identified. We conducted community-based waterpark-based case-control studies examine potential sources the outbreak. collected stool specimens from ill persons pool water samples...
This report describes the signalment, clinical findings, gross appearance, histological and immunohistochemical characteristics, behavior of 39 cases canine synovial myxoma. Large-breed middle-aged dogs-especially, Doberman Pinschers Labrador Retrievers-were most commonly affected. The stifle digit were common sites. Grossly, tumors composed gelatinous nodules that often filled joint cavity exuded viscous fluid on cut section. In 12 (31%), radiographic bony lysis or grossly invasive growth...