A5078012011- Neuroblastoma Research and Treatments
- Neuroscience of respiration and sleep
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- RNA and protein synthesis mechanisms
- CAR-T cell therapy research
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- DNA and Nucleic Acid Chemistry
- Neonatal and fetal brain pathology
- Plant Reproductive Biology
- Plant tissue culture and regeneration
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- Plant Pathogens and Fungal Diseases
- Cancer, Hypoxia, and Metabolism
- Pain Mechanisms and Treatments
- Cancer Research and Treatments
- Neuropeptides and Animal Physiology
- Chromatin Remodeling and Cancer
- Plant Virus Research Studies
- interferon and immune responses
- Traditional Chinese Medicine Analysis
University of Calgary
2012-2024
Shanxi Agricultural University
2021-2024
Institute of Pomology
2021-2024
China International Science and Technology Cooperation
2024
Guangxi University
2023
Alberta Children's Hospital
2014-2022
Alberta Children's Hospital Research Institute
2017-2022
Luoyang Central Hospital Affiliated to Zhengzhou University
2014-2020
Shanxi Academy of Agricultural Sciences
2016-2017
Iwate University
2011-2016
Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic compound virus therapies also modulate host immune responses in ways we hypothesized would complement one another promoting anticancer T-cell immunity. We show that synergize driving CD8
Abstract Objective To investigate the role of proteinase‐activated receptor 4 (PAR‐4) in mediating joint inflammation and pain mice. Methods Knee blood flow, edema, sensitivity (as induced by thermal mechanical stimuli) were assessed C57BL/6 mice following intraarticular injection either selective PAR‐4 agonist AYPGKF‐NH 2 or inactive control peptide YAPGKF‐NH . The mechanism action was examined pretreatment each mouse with antagonist pepducin P4pal‐10 bradykinin HOE 140. Finally, tested...
The myotubularins are a large family of inositol polyphosphate 3-phosphatases that, despite having common substrates, subsume unique functions in cells that disparate. myotubularin consists 16 different proteins, 9 members which possess catalytic activity, dephosphorylating phosphatidylinositol 3-phosphate [PtdIns(3)P] and 3,5-bisphosphate [PtdIns(3,5)P 2 ] at the D-3 position. Seven inactive because they lack conserved cysteine residue CX 5 R motif required for activity. We studied...
Emerging evidences support that oral microbiota are associated with health and diseases of esophagus. How change in Chinese patients esophageal cancer (EC) is unknown, neither the biomarker role them. For an objective to understand alterations EC patients, we conducted a case-control study including saliva samples from 39 51 healthy volunteers. 16S rDNA genes V3-V4 variable regions were sequenced identify taxon. Relationship between flora disease was analyzed according alpha diversity beta...
Dopamine (DA) plays an essential role in dopaminergic neuronal behavior and disease. However, current detection methods for discriminating the secretion of DA are hampered by limitations requirement bulky instrumentation non-intuitive signals. Herein, we have controllably proportionately integrated molybdenum disulfide (MoS2) with titanium dioxide (TiO2) to prepare MoS2@TiO2 nanocomposites (MoS2@TiO2 NCs) via a facile synthesis method. NCs certain reactant mass ratio shown significant...
When RNA polymerase II (RNAP II) is forced to stall, elongation complexes (ECs) are observed leave the active pathway and enter a paused state. Initially, ECs equilibrate between conformations, but with stalls of long duration, backtrack become sensitive transcript cleavage, which stimulated by EC rescue factor stimulatory (TFIIS/SII). In this work, rates for equilibration pausing pathways were estimated in absence an factor, presence hepatitis δ antigen (HDAg), transcription IIF (TFIIF), or...
Abstract Objective To determine whether peripheral administration of the endogenous μ‐opioid peptide endomorphin 1 could reduce knee joint pain, using animal models acute and chronic arthritis. Methods Extracellular electrophysiologic recordings were made rat primary afferent nerve activity in response to noxious hyperrotation joint. Neuronal was assessed before following local injection 1. Comparisons between normal knees with adjuvant‐induced monarthritis, tested at 48 hours week...
Primary hepatocellular carcinoma (HCC) is one of the most common malignant tumors. At present, molecular mechanism HCC remains unclear. A recent circular RNA (circRNA) profiling study showed that circRBM23 expression was upregulated in tissues. Therefore, this study, impact during progression evaluated. The levels and miR-138 tissues cell lines were determined by RT-PCR results indicated increased lines, whereas decreased. An upregulation cells shown to increase viability, also ability...
Oncolytic virus (OV) therapy is an emerging cancer treatment that uses replicating viruses to infect and kill tumor cells incite anticancer immunity. While the approach shows promise, it currently fails most patients, indicating strategies improve OV activity are needed. Developing these will require greater understanding of biology, particularly in context delivery clearance, infection process within a complex microenvironment, modulation To help achieve this, we have established technique...
The role of the RAP74 alpha1 helix transcription factor IIF (TFIIF) in stimulating elongation by human RNA polymerase II (RNAP II) was examined using millisecond-phase transient-state kinetics. deletion mutants RAP74(1-227), which includes an intact helix, and RAP74(1-158), is deleted, were compared. Analysis TFIIF RAP74-RAP30 complexes carrying RAP74(1-158) reveals because this mutant has indistinguishable activity compared to 74(W164A), carries a critical point mutation alpha1. We report...
The enzyme inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) catalyzes the rate-limiting step in formation of higher phosphorylated forms mammalian cells. Because it sits at a key regulatory point metabolic pathway, its activity is likely to be regulated. We have previously shown that ITPK1 phosphorylated, posttranslational modification used by cells regulate activity. show here modified acetylation internal lysine residues. sites, as determined mass spectrometry, were found lysines 340, 383,...
The peripheral effect of the ‘opioid‐like’ peptide nociceptin/orphanin FQ (N/OFQ) on joint blood flow was investigated in acutely inflamed rats. Sensory neuropeptide release from capsaicin‐sensitive nerves and involvement synovial mast cells leukocytes these vasomotor responses were also studied. Blood measurements exposed knee joints performed urethane‐anaesthetised rats (2 mg kg −1 intraperitoneal) using laser Doppler perfusion imaging. Topical administration N/OFQ (10 −13 –10 −8 mol) to...
To establish better embryo induction procedures in anther culture of apple, the relationships between microspore stage and flower bud stage, developmental microspores during cold pre-treatment buds were investigated. We classified stages into four: "Tight cluster", "First pink", "Pink", "Full pink". Each was defined by a morphological characteristic. The seven: "tetrads", "early uninucleate", "mid-uninucleate", "late binucleate", "mature grain". characteristic each clarified. cluster" mainly...