A5101966407- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- China's Ethnic Minorities and Relations
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Social Work Education and Practice
- Anesthesia and Sedative Agents
- HIV/AIDS drug development and treatment
- Lung Cancer Research Studies
- Malaria Research and Control
- Colorectal Cancer Treatments and Studies
- Medical Research and Treatments
- Lung Cancer Treatments and Mutations
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Winter Sports Injuries and Performance
- Food Science and Nutritional Studies
- S100 Proteins and Annexins
- Regional Economic and Spatial Analysis
- Growth Hormone and Insulin-like Growth Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological Disease Mechanisms and Treatments
- Physical Activity and Education Research
State Key Laboratory of Respiratory Disease
2011-2024
Guizhou University
2024
The First People's Hospital of Shunde
2024
Jinan University
2024
The Affiliated Shunde Hospital of Jinan University
2024
Guangzhou Medical University
2023-2024
Beijing Sport University
2006-2024
Fourth Affiliated Hospital of Guangxi Medical University
2024
Guangxi Medical University
2022
Fujian Medical University
2022
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays master role in blocking ferroptosis eliminating phospholipid hydroperoxides, the regulation remains poorly understood. Here, we report an unexpected for copper promoting ferroptotic death, but not cuproptosis, inducing macroautophagic/autophagic degradation GPX4. Copper chelators reduce sensitivity do inhibit other...
Hepatoid adenocarcinoma of the stomach (HAS) is a rare and aggressive malignancy with poor prognosis. HAS characterized by both hepatocellular carcinoma like differentiation, which often produces alpha-fetoprotein (AFP) responds poorly to systemic chemotherapy. Herein we report case 62-year-old male diagnosed liver metastatic HAS, who progressed rapidly after first-line cisplatin + fluorouracil chemotherapy combined pembrolizumab. However, patient achieved favourable outcome second-line...
Surgical intervention for stage IV non-small cell lung cancer (NSCLC) is still controversial. This study sought to evaluate the clinical effects of surgical on survival in patients with NSCLCs and identify cohort benefitting most from surgery. A retrospective Surveillance, Epidemiology, End Results database was performed compare NSCLC who had undergone surgery those did not undergo Overall (OS) evaluated using Kaplan–Meier method log-rank test. The Cox proportional hazards model used...
Identification of novel chemotypes with antimalarial efficacy is imperative to combat the rise Plasmodium species resistant current drugs. We have used a hybrid target-phenotype approach identify and evaluate for malaria. In our search drug-like aspartic protease inhibitors in publicly available phenotypic databases, we identified GNF-Pf-4691, 4-aryl- N-benzylpyrrolidine-3-carboxamide, as having structure reminiscent known proteases. Extensive profiling two terminal aryl rings revealed...
Apatinib is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, which shows good efficacy and safety in clinical trials for chemotherapy-refractory gastric cancer patients. Till now, there no case report after apatinib came the market. We presented 55-year-old Chinese woman with advanced cancer, who received failure of second-line chemotherapy. On 19th day administration, she suffered from gastrointestinal hemorrhage. Then, her condition rapidly...
Abstract The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic mesenchymal stem cells residing in marrow, ultimately playing a role development osteoporosis (OP). Mitigating ROS levels is promising approach counteracting OP. In this study, nanozyme composed magnesium-based zeolitic imidazolate frameworks (Mg-ZIF) was engineered effectively scavenge alleviate results study indicate that...
An imbalance of intracellular iron metabolism can lead to the occurrence ferroptosis. Ferroptosis be a factor in remodeling immune microenvironment and affect efficacy cancer immunotherapy. How combine ferroptosis-promoting modalities with immunotherapy suppress triple-negative breast (TNBC) has become an issue great interest therapy. However, potential biomarkers related regulation TNBC remain poorly understand.We constructed optimal prognostic TNBC-IMRGs (iron immune-related genes)...
To compare the pharmacokinetics of cefquinome sulfate in ducklings and goslings after IV or IM administration a single dose.216 healthy Muscovy (Cairina moschata) 216 Sichuan white (Anser cygnoides).Ducklings were each randomly assigned to 3 groups (n = 72/group) that received dose (2 mg/kg) injectable administered suspension IM. Blood samples collected at various points drug 6 birds/time point). Plasma concentrations measured by high-performance liquid chromatography with UV detection,...
Energy metabolism and motion are the essence of dance. Scientific training athletes involves theoretical guidance in terms fitness, talent-based selection, high-performance practice. However, limited research work is carried out on physiological strain DanceSport competitions. Therefore, proper channel needs to be established for aerobic-based exercise participant's performance general fitness. Competition simulation used collect personal data from real-time experimentations. Database...
Objective This research investigates the influence of passion on DanceSport engagement (DSE) among university students specializing in DanceSport, along with mediating function partnership (DSP). Methods A survey involving 1,029 participants was conducted using Passion Scale, Athlete Engagement Questionnaire, and Chinese Partnership Scale. Results There were significant positive associations passion, DSP, DSE. The path coefficient revealed that had a 0.631 ( p < 0.001) effect DSE,...
Gastric cancer is the second most prevalent and leading cause of cancer-related death in China. The prognosis metastatic gastric poor with a median overall survival 8-10 months. Apatinib, an oral small-molecule, selective vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, approved as third-line or subsequent therapy for Several recent small-scale studies case reports showed that it may be great help improvement second-line treatment patients advanced cancer. Here, we...
The 2017 Annual Meeting of Chinese Anthropological Society Li XiaofeniD and Sun NaiD (2017 Nian Zhongguo Renleixue Xuehui Xueshu Nianhui),1 was sponsored by the (CAS),2 Inner Mongolia Normal University (Neimenggu Shifan Daxue),3 Association Science in Autonomous Region Zizhiqu Shehui Kexuejie Lianhehui).4 It co-hosted Institute Ethnology Anthropology Advanced Studies Daxue Minzuxue Gaodeng [End Page 454] Yanjiuyuan),5 Coordination Innovation Center Research on Ethnic Culture alongside Grass...