A5100349901- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Estrogen and related hormone effects
- Malaria Research and Control
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Advanced Photocatalysis Techniques
- HIV/AIDS drug development and treatment
- Retinoids in leukemia and cellular processes
- Conducting polymers and applications
- Psoriasis: Treatment and Pathogenesis
- Eosinophilic Esophagitis
- Reproductive Biology and Fertility
- Mosquito-borne diseases and control
- Organic Electronics and Photovoltaics
- Advanced oxidation water treatment
- Genetic factors in colorectal cancer
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Extraction and Separation Processes
- Ocular Surface and Contact Lens
- Hepatitis B Virus Studies
- Organoboron and organosilicon chemistry
Chinese Academy of Sciences
2016-2025
National Health Research Institutes
2014-2025
Tangshan Gongren Hospital
2024
Shanghai Institute of Microsystem and Information Technology
2021-2024
University of Chinese Academy of Sciences
2007-2024
Institute of Chemistry
2013-2024
Southeast University
2024
Lanzhou Institute of Chemical Physics
2019-2024
Suzhou Research Institute
2019-2024
Bengbu Medical College
2024
Alzheimer9s disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Aβ oligomers has been proposed to be largely responsible for AD dementia deficits the Tg2576 mice, model AD. In this study, we found that naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into <i>in vitro</i>. When orally administered preparation...
Abstract The development of a methodology for synthesizing value‐added urea (CO(NH 2 ) via renewable electricity‐driven C−N coupling reaction under mild conditions is highly anticipated. However, the complex catalytic active sites that act on carbon and nitrogen species make mechanism unclear, resulting in low efficiency from co‐reduction dioxide (CO nitrate (NO 3 − ). Herein, we propose novel tandem catalyst Mo‐PCN‐222(Co), which Mo serve to facilitate reduction *NH intermediate, while Co...
Recombinant adeno-associated virus type 2 (AAV) is a common vector used in human gene therapy protocols. We characterized the humoral immune response to AAV and observed that 80% of normal subjects have anti-AAV antibodies 18% neutralizing antibodies. To analyze effect on readministration, we attempted deliver recombinant expressing factor IX (AAV-hFIX) intraportally into livers mice which had been preexposed shown harbor antibody response. While all naive control expressed hFIX following...
Background Lung cancer is the most common malignancy in humans and its high fatality means that no effective treatment available. Developing new therapeutic strategies for lung urgently needed. Malaria has been reported to stimulate host immune responses, which are believed be efficacious combating some clinical cancers. This study aimed provide evidence malaria parasite infection cancer. Methodology/Principal Findings Antitumor effect of was examined both subcutaneously intravenously...
We herein report an iridium-catalyzed enantioselective α-C(sp3)–H borylation of a wide range azacycles. The combination iridium precursor and chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C–H bonds from single carbon center, affording variety synthetically useful azacycles readily available starting materials with good excellent enantioselectivities.
Malaria is caused by protozoan erythrocytic parasites of the Plasmodium genus, with falciparum being most dangerous and widespread disease-causing species. Falcipain-2 (FP-2) P. a papain-family (C1A) cysteine protease that plays an important role in parasite life cycle degrading erythrocyte proteins, notably hemoglobin. Inhibition FP-2 its paralogues prevents maturation, suggesting these proteins may be valuable targets for design novel antimalarial drugs, but lack structural knowledge has...
The preferential localization of some neoplasms, such as serrated polyps (SPs), in specific areas the intestine suggests that nongenetic factors may be important for their development. To test this hypothesis, we took advantage transgenic mice expressed HB-EGF throughout but developed SPs only cecum. Here show a host-specific microbiome was associated with and alterations microbiota induced by antibiotic treatment or embryo transfer rederivation markedly inhibited formation Mechanistically,...
Increased expression of Interleukin (IL)-33 has been detected in intestinal samples patients with ulcerative colitis, a condition associated increased risk for colon cancer, but its role the development colorectal cancer yet to be fully examined. Here, we investigated epithelial expressed IL-33 during tumors. was cells specimens and Apc Min/+ mice. To better understand epithelial-derived tumorigenesis, generated transgenic mice expressing (V33 mice). V33 mice, resulting from cross had tumor...
Abstract We herein report amide directed enantioselective β‐C(sp 3 )−H borylation of unbiased methylene C−H bonds acyclic amides enabled by iridium catalysis for the first time. The key to success this transformation relies on careful selection combination precursor and chiral bidentate boryl ligands. A variety functional groups are well‐tolerated, affording β‐functionalized in good excellent enantioselectivities. also demonstrate application current method stereospecific conversion C−B bond...
Signaling by the B cell–activating receptor TACI drives T cell–independent IgA responses to gut commensal bacteria.
Glucose transporter 4 (GLUT4) is a principal glucose in response to insulin, and impaired translocation or decreased expression of GLUT4 believed be one the major pathological features type 2 diabetes mellitus (T2DM). Therefore, induction or/and promising strategy for anti-T2DM drug discovery. Here we report that natural product (+)-Rutamarin (Rut) functions as an efficient dual inducer on both insulin-induced expression. Rut-treated 3T3-L1 adipocytes exhibit efficiently enhanced uptake,...
LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis 11, 26 new derivatives (12a–z) were designed and synthesized accordingly. Five (12f–g, 12p, 12u, 12y) showed better activities than 11. Remarkably, most potent derivative, 12u (8.96 3.62 μM), capability approximately 10 times 8-fold higher that control (GS) starting respectively. was further confirmed to have high binding...
Nuclear receptors retinoic X receptor α (RXRα) and peroxisome proliferator activated γ (PPARγ) function potently in metabolic diseases, are both important targets for anti-diabetic drugs. Coactivation of RXRα PPARγ is believed to synergize their effects on glucose lipid metabolism. Here we identify the natural product magnolol as a dual agonist targeting PPARγ. Magnolol was previously reported enhance adipocyte differentiation uptake, ameliorate blood level prevent development diabetic...