A5090849323- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Flavonoids in Medical Research
- Polysaccharides and Plant Cell Walls
- interferon and immune responses
- Fungal Biology and Applications
- Biochemical and Molecular Research
- Protein Hydrolysis and Bioactive Peptides
- Chemical Synthesis and Analysis
- Natural product bioactivities and synthesis
- Amino Acid Enzymes and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Respiratory viral infections research
- Phytochemical compounds biological activities
- Folate and B Vitamins Research
- Polyamine Metabolism and Applications
- Antibiotic Resistance in Bacteria
- Toxin Mechanisms and Immunotoxins
- Microbial Metabolic Engineering and Bioproduction
- Inflammatory Bowel Disease
- Gut microbiota and health
- Venomous Animal Envenomation and Studies
China Pharmaceutical University
2016-2025
Shanghai Jiao Tong University
2024
Dongguan People’s Hospital
2021-2022
Guangdong Medical College
2020-2021
Harbin Medical University
2016-2020
Second Affiliated Hospital of Harbin Medical University
2016-2020
Jining First People's Hospital
2018
First Hospital of Jilin University
2015
Jilin University
2015
Tasly Holding Group (China)
2013
Abstract Baicalin is a natural flavonoid glycoside which has potent anti-tumor and antioxidant activity in cancer cells. In the present study, we found that baicalin treatment significantly induced senescence colon Furthermore, upregulated expression of decidual protein by progesterone (DEPP) HCT116 cells, accompanied with activation Ras/Raf/MEK/ERK p16 INK4A /Rb signaling pathways. Meanwhile, these phenomena also appeared under anti-oxidation effect exerted baicalin. addition, ectopic DEPP...
Baicalein and baicalin are active components of the Scutellaria baicalensis Georgi both have broad anti-tumor activity. However, how whether baicalein inhibit colon cancer is unclear. Here we demonstrate that can significantly human cell growth proliferation. Furthermore, induce cycle arrest, suppress colony formation migration. The suppressive effects mechanistically due to induction apoptosis senescence mediated by baicalin, respectively. revealed baicalin-induced in tumor cells its...
Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years. We investigated the anti-inflammatory effects and underlying mechanisms HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).Experimental mice were given 3% DSS, (2.275, 4.55, 9.1 g/kg), or mesalazine (ME, 200 mg/kg) orally 7 days. Body weight loss, disease activity index (DAI), colon length, histology, levels...
Baicalein, an extract from Scutellaria baicalensis, was evaluated for its ability to inhibit the influenza virus in vivo. Oral administration of baicalein BALB/c mice infected with A/FM1/1/47(H1N1) showed significant effects preventing death, increasing mean time inhibiting lung consolidation, and reducing titer a dose-dependent manner. These are believed be due baicalin, metabolite serum. At concentration baicalin 2 μg/ml overlay medium, it inhibition plaque assay, IC50 value calculated as...
The structural modification of existing AMPs is an effective strategy to develop antimicrobial agents with high-efficiency, low-cost and low-toxicity agents. Methods: Here, we truncated 14-amino-acids at the N-terminus MSI-78 obtain MSI further modified four peptide analogs: MSI-1, MSI-2, MSI-3 MSI-4. These mutants were evaluated regarding their antibacterial activity against various sensitive or resistant bacteria; toxicity mammalian cells mice; stability violent pH, temperature variations...
Cataract is considered as the most common cause of blindness, which curable only by surgery. Postsurgery, however, many patients gradually develop complication posterior capsule opacification (PCO) or secondary cataract, arising from stimulated cell proliferation and migration within lens capsule. The human epithelial cells (HLECs) plays crucial roles in remodeling cataract formation, but less known about cell-signaling mechanism migration. We observed that growth factor (EGF) induced...
It has been demonstrated that microRNAs (miRNAs) play an important role in the carcinogenesis of osteosarcoma.The aim present study was to determine diagnostic and prognostic value serum miR-124 expression levels 114 osteosarcoma patients, 40 periostitis patients 50 normal controls were detected using real-time quantitative polymerase chain reaction (RT-qPCR).The level remarkably decreased when compared healthy (both p< 0.05). The significantly elevated after receiving surgical treatment (p<...
Abstract 3‐Hydroxyacyl‐CoA dehydratase 2 (HACD2), an obesity‐related gene involved in the elongation of long‐chain fatty acids, is highly expressed pancreatic cancer (PC) and associated with patient prognosis. Interestingly, study reveals that HACD2 mediated proliferation PC cells a dehydratase‐independent manner, affecting downstream glycolytic pathway. Mechanistically, promotes by binding to E3 ubiquitin‐protein ligase parkin (PRKN) enhancing pyruvate kinase PKM (PKM2) dissociation from...
Trichostatin A (TSA), a hydroxamate-type inhibitor of mammalian histone deacetylases, is emerging as one potentially new class anticancer agents. TSA known to act by promoting the acetylation histones, leading uncoiling chromatin and activation variety genes implicated in regulation cell survival, proliferation, differentiation, apoptosis. In addition, there an increasing appreciation fact that may through mechanisms other than induction acetylation. Accumulated experimental data indicate...
Ovarian cancer remains the leading cause of fatality among all gynecologic cancers, although promising therapies are in making. It has been speculated that metastasis is critical for ovarian cancer, and yet molecular mechanisms poorly understood. Growth factors have proven to play important roles cell migration associated with metastasis, inhibition growth factor receptors their distinct signaling pathways intensively studied, uncovered interaction or crosstalk various complicates this...
We isolated and characterized a novel virulent bacteriophage, IME-EFm1, specifically infecting multidrug-resistant Enterococcus faecium. IME-EFm1 is morphologically similar to members of the family Siphoviridae. It was found capable lysing wide range our E. faecium collections, including two strains resistant vancomycin. One-step growth tests revealed host lysis activity phage with latent time 30 min large burst size 116 p.f.u. per cell. These biological characteristics suggested that has...
Ulcerative colitis is a type of chronic inflammation present in the intestines for which aetiology not yet clear. The current therapies ulcerative cannot be considered to long-term management strategies due their significant side effects. Therefore, it essential identify an alternative therapeutic strategy colitis. study focused on evaluation anti-inflammatory activities Lactobacillus acidophilus CGMCC 7282 and Clostridium butyricum 7281. roles both single combination L. C. 7281 were...