A5100446180- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Natural Compound Pharmacology Studies
- NF-κB Signaling Pathways
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Neuroscience and Neuropharmacology Research
- Advanced biosensing and bioanalysis techniques
- Advanced Chemical Sensor Technologies
- Luminescence and Fluorescent Materials
- Axial and Atropisomeric Chirality Synthesis
- Alkaloids: synthesis and pharmacology
- Gut microbiota and health
- Plant-derived Lignans Synthesis and Bioactivity
- Immune cells in cancer
- Calcium signaling and nucleotide metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Sensors and Ion Detection
- Natural Compounds in Disease Treatment
- Plant biochemistry and biosynthesis
- Photoreceptor and optogenetics research
- Ziziphus Jujuba Studies and Applications
- Biosensors and Analytical Detection
- Memory and Neural Mechanisms
First Affiliated Hospital of Jinan University
2023-2025
China Pharmaceutical University
2007-2023
Shenyang Pharmaceutical University
2018
Nanjing University
2007
Bacterial infections routinely cause serious problems to public health. To mitigate the impact of bacterial infections, sensing systems are urgently required for detection and subsequent epidemiological control pathogenic organisms. Most conventional approaches time-consuming highly instrument- professional operator-dependent. Here, we developed a novel one-component multichannel array constructed with complex made from three modified polyethyleneimine as well negatively charged graphene...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and early diagnosis of AD remains challenging. Here we have developed a fluorescent sensor array composed three modified polyamidoamine dendrimers. Proteins various properties were differentiated via this with 100% accuracy, proving rationality array's design. The mechanism fluorescence response was discussed. Furthermore, robust three-element enables parallel detection multiple Aβ40/Aβ42 aggregates (0.5 μM) in...
Garcioblons A-F (1-6), six unprecedented polycyclic polyprenylated acylphloroglucinols (PPAPs) formed via intramolecular Diels-Alder (IMDA) reactions from monocyclic (MPAPs), were isolated Garcinia oblongifolia. Their structures elucidated through spectroscopic analysis and quantum calculations. Structurally, compound 1 is the first PPAP characterized by an 6/6/5/7/6/5/6/5 octacyclic ring system with a 11-oxatetracyclo[8.5.1.01,12.05,10]hexadecane motif, while 2-4 are its biogenetically...
Ulcerative colitis is a type of chronic inflammation present in the intestines for which aetiology not yet clear. The current therapies ulcerative cannot be considered to long-term management strategies due their significant side effects. Therefore, it essential identify an alternative therapeutic strategy colitis. study focused on evaluation anti-inflammatory activities Lactobacillus acidophilus CGMCC 7282 and Clostridium butyricum 7281. roles both single combination L. C. 7281 were...
Compounds <bold>1–4</bold> represent the first examples of natural atropisomeric meroterpenoids with a rare triketone-phloroglucinol-terpene skeleton.
Bioactive flavonoids, the major ingredients of red wines, have been proven to prevent atherosclerosis and cardiovascular disease due their anti-inflammatory anti-oxidant activity. However, flavonoids challenging identify, even when multiple approaches are combined. Hereby, a simple array was constructed detect by employing phenylboronic acid modified perylene diimide derivatives (PDIs). Through non-specific interactions (hydrophilic, hydrophobic, charged, aromatic, hydrogen-bonded reversible...
Generalization of visual aversion is a critical function the brain that supports survival, but underlying neurobiological mechanisms are unclear. We establish rapid generalization procedure for inducing by dynamic stripe images. By using fiber photometry, apoptosis, chemogenetic and optogenetic techniques, behavioral tests, we find decreased cholinergic neurons' activity in medial septum (MS) leads to loss aversion. Strikingly, identify projection from MS neurons habenula (MHb) inhibition...
Frutescone O was isolated from the aerial parts of Baeckea frutescens L., which commonly used as a folk medicinal material for treating anti-inflammatory disease in South East Asia. This study aimed to investigate activity and related signaling cascade (Fru) LPS induced RAW264.7 cells. The anti-inflammation determined according inhibitory effects on secretion nitric oxide (NO), expression inducible NO synthase, pro-inflammatory cytokines. regulation Myeloid differentiation factor 88 (Myd88),...
A new sesquiterpeniod, 6α, 7α, 10α-trihydroxyisoducane (1), together with two known sesquiterpenoids, oplodiol (2) and oplopanone (3), were isolated from the chloroform extract of rhizomes Homalomena occulta. Their structures elucidated by 1D 2D NMR spectral interpretation.
Biomimetic total syntheses of the natural tasmanone-based meroterpenoids were achieved for first time <italic>via</italic> Michael addition, oxidative [4 + 2] cycloaddition, and water-promoted Diels–Alder click reactions.
Abstract Dammarane-type saponins, the main active ingredients of Panax notoginseng, have substantial neuroprotective effects in different animal models neurodegenerative diseases. However, because these compounds structures, level protection provided by individual varies, and highly can be selected based on structure-activity relationships. Glutamate is a major excitatory neurotransmitter that plays an important role synaptic response development. excessive extracellular glutamate levels...
Pfaffia paniculata is a commercialized dietary supplement used as the substitute for Asian ginseng in Brazil. We conducted systematic isolation of EtOAc fraction with anti-inflammatory effect and two new triterpenoids, along 26 known compounds were characterized by means MS NMR analysis. Interestingly, compound 1 first seco-ring triterpenoid reported genus. Furthermore, among compounds, 14 15 exhibited activity Caco-2 cells, but showed no anti-inflammatory.