A5070973535- Hydrocarbon exploration and reservoir analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Phase Equilibria and Thermodynamics
- Chemical and Physical Properties in Aqueous Solutions
- Antimicrobial Peptides and Activities
- Thermodynamic properties of mixtures
- Exercise and Physiological Responses
- Inflammasome and immune disorders
- Enhanced Oil Recovery Techniques
- Geological and Geophysical Studies
- Crystallization and Solubility Studies
- Probiotics and Fermented Foods
- Glaucoma and retinal disorders
- Geological Studies and Exploration
- Acute Ischemic Stroke Management
- Analytical Chemistry and Chromatography
- Bacterial Genetics and Biotechnology
- Peripheral Neuropathies and Disorders
- Dietary Effects on Health
- Pediatric Pain Management Techniques
- Antifungal resistance and susceptibility
- Venous Thromboembolism Diagnosis and Management
- Gene Regulatory Network Analysis
- Process Optimization and Integration
- Biochemical and Structural Characterization
Southwest Hospital
2022-2025
Shanghai University of Sport
2023-2025
University of Electronic Science and Technology of China
2024-2025
Army Medical University
2022-2025
Northwest University
2025
Nanjing Drum Tower Hospital
2020-2024
Hubei University of Chinese Medicine
2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
Bacteria tightly regulate and coordinate the various events in their cell cycles to duplicate themselves accurately control sizes. Growth of Escherichia coli, particular, follows a relation known as Schaechter 's growth law. This law says that average volume scales exponentially with rate, scaling exponent equal time from initiation round DNA replication division at which corresponding sister chromosomes segregate. Here, we sought test robustness systematic perturbations dimensions achieved...
NLRP3 inflammasome plays a critical spatiotemporal role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). This study reports mechanistic insight into noncanonical activation microglia for effector stage EAE. Microglia-specific deficiency ASC (apoptosis-associated speck-like protein containing C-terminal caspase-activation and recruitment [CARD] domain) attenuated T cell expansion neutrophil during EAE pathogenesis. Mechanistically, TLR stimulation led to...
The structural modification of existing AMPs is an effective strategy to develop antimicrobial agents with high-efficiency, low-cost and low-toxicity agents. Methods: Here, we truncated 14-amino-acids at the N-terminus MSI-78 obtain MSI further modified four peptide analogs: MSI-1, MSI-2, MSI-3 MSI-4. These mutants were evaluated regarding their antibacterial activity against various sensitive or resistant bacteria; toxicity mammalian cells mice; stability violent pH, temperature variations...
Ofatumumab presents a potentially promising alternative to current second-line immunotherapy for refractory anti-N-methyl-D-aspartate receptor autoimmune encephalitis (NMDAR-AE). We aimed evaluate the efficacy and safety of ofatumumab as novel NMDAR-AE. This prospective, multicenter, nested cohort study compared patients with NMDAR-AE from CHina Autoimmune encephalitiS outcomE registry (CHASE) recruited between October 2011 February 2024, treated without ofatumumab. The primary outcome was...
Cronobacter sakazakii is a food-borne pathogen that can thrive in various environments, including the human body. The body’s physiological temperature exceeds of environment (22–30 °C), necessitating adaptations to heat stress during this transition. Managing crucial when transitioning from In study, we explored effect body on growth planktonic C. sakazakii, as well its acid resistance, osmotic autoaggregation, and cell surface hydrophobicity. Our study demonstrated facilitated growth,...
Multiple sclerosis is a severe autoimmune disorder that mainly mediated by pathogenic cluster of CD4+ T cell subsets. Despite advancements in the management multiple sclerosis, there critical need for more effective and safer treatments. In present study, we administered Lycium barbarum glycopeptide to mouse model experimental encephalomyelitis-an animal sclerosis-and evaluated its effects on activation both vivo vitro. significantly mitigated clinical severity encephalomyelitis, as...
Chronic obstructive pulmonary disease (COPD) is frequently accompanied by skeletal muscle dysfunction, a critical and severe extrapulmonary complication. This dysfunction contributes to reduced exercise capacity, increased frequency of acute exacerbations, elevated mortality, serving as an independent risk factor for poor prognosis in COPD patients. Owing the unique physicochemical conditions marine environment, marine-derived bioactive compounds exhibit potent anti-inflammatory antioxidant...
Abstract For centuries, the herb Atractylodes lancea (Thunb.) has been revered for its pharmacological properties, particularly efficacy in combating spleen and stomach ailments. However, prolonged artificial cultivation of A. led to an increased presence serious plant diseases, including flat branch disease caused by phytoplasmas. To elucidate mechanisms stem (FS) formation, physiological biochemical indicators, as well related metabolic pathways were assessed stems following phytoplasma...
Abstract Although Act1 (adaptor for IL-17 receptors) is necessary IL-17-mediated inflammatory responses, - (but not Il17ra- , Il17rc- or Il17rb -) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that functions as a negative regulator in T B cells via direct inhibition of STAT3. Mass spectrometry analysis detected an Act1–STAT3 complex, deficiency Il17ra -, ) results hyper IL-23- IL-21-induced STAT3 activation cells, respectively. IL-23R deletion blockade...
Preoperative anxiety in children is harmful. Despite this, there a scarcity of studies examining the incidence preoperative and its related effects China. This study investigated aged 2 to 7 pediatric surgery department tertiary hospital The factors influencing these were identified.The researchers used Chinese version modified Yale Anxiety Scale (CmYPAS) Short Form CmYPAS (CmYPAS-SF) assess state who underwent elective China from July 1, 2020 September 30, enrolled this study. generalized...