A5101559346- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Herpesvirus Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
- interferon and immune responses
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
Sichuan University
2023-2025
West China Hospital of Sichuan University
2023-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2023-2025
Abstract More than half of epileptic patients ultimately turned to intractable epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), the most common type epilepsies, whose pathological mechanism remains elusive. Here, using 42 human samples from surgical donors MTLE (32 and 10 without HS) through single-cell resolution Stereo-seq histologcial experiments, we revealed spatially changes gene expression cell composition HS systematically. After precise parcellation...
Ofatumumab presents a potentially promising alternative to current second-line immunotherapy for refractory anti-N-methyl-D-aspartate receptor autoimmune encephalitis (NMDAR-AE). We aimed evaluate the efficacy and safety of ofatumumab as novel NMDAR-AE. This prospective, multicenter, nested cohort study compared patients with NMDAR-AE from CHina Autoimmune encephalitiS outcomE registry (CHASE) recruited between October 2011 February 2024, treated without ofatumumab. The primary outcome was...
<title>Abstract</title> Background In adult N-methyl-D-aspartate receptor (NMDAR) encephalitis, corticosteroids are commonly used as first-line treatment. However, the optimal oral prednisone tapering (OPT) following intravenous methylprednisolone pulse therapy remains unclear. We aim to compare efficacy and safety of different OPT course in NMDAR encephalitis. Methods The CHASE study, a multicenter, prospective, observational cohort enrolled patients diagnosed with autoimmune encephalitis...