A5101785512- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Fish Ecology and Management Studies
- interferon and immune responses
- Hydrology and Watershed Management Studies
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Dermatology and Skin Diseases
- Myofascial pain diagnosis and treatment
- Hydrology and Sediment Transport Processes
- Exercise and Physiological Responses
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
Tencent (China)
2025
State Key Laboratory of Hydraulics and Mountain River Engineering
2022
Sichuan University
2022
Nantong University
2018-2021
Northwestern University
2020
Toll-like receptors (TLRs) are nucleic acid–sensing and have been implicated in mediating pain itch. Here we report that Tlr8−/− mice show normal itch behaviors, but defects neuropathic induced by spinal nerve ligation (SNL) mice. SNL increased TLR8 expression small-diameter IB4+ DRG neurons. Inhibition of the attenuated SNL-induced hypersensitivity. Conversely, intrathecal or intradermal injection agonist, VTX-2337, TLR8-dependent Mechanistically, TLR8, localizing endosomes lysosomes,...
Abstract More than half of epileptic patients ultimately turned to intractable epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), the most common type epilepsies, whose pathological mechanism remains elusive. Here, using 42 human samples from surgical donors MTLE (32 and 10 without HS) through single-cell resolution Stereo-seq histologcial experiments, we revealed spatially changes gene expression cell composition HS systematically. After precise parcellation...
The entorhinal-hippocampal circuit can encode features of elapsed time, but nearly all previous research focused on neural encoding "implicit time." Recent has revealed "explicit time" in the medial entorhinal cortex (MEC) as mice are actively engaged an interval timing task. However, it is unclear whether MEC required for temporal perception and/or learning during such explicit tasks. We therefore optogenetically inactivated learned "door stop" task that immobile behavior and...
Dam removal is considered an effective measure to solve the adverse ecological effects caused by dam construction and has started be in China. The sediment migration habitat restoration of river ecosystems after have been extensively studied abroad but are still exploratory stage However, there few studies on response fishes at different growth stages. Considering preferences Schizothorax prenanti (S. prenanti) spawning juvenile periods, this study coupled field survey data a two-dimensional...