A5030740758- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Tryptophan and brain disorders
- Herpesvirus Infections and Treatments
- Insect and Arachnid Ecology and Behavior
- Artificial Intelligence in Healthcare and Education
- Infectious Encephalopathies and Encephalitis
- Cellular transport and secretion
- Cytomegalovirus and herpesvirus research
- Insect Pheromone Research and Control
- Circadian rhythm and melatonin
- Heart Rate Variability and Autonomic Control
- RNA regulation and disease
- Land Use and Ecosystem Services
- Blood Pressure and Hypertension Studies
- High voltage insulation and dielectric phenomena
- Clostridium difficile and Clostridium perfringens research
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Big Data and Business Intelligence
- Effects and risks of endocrine disrupting chemicals
- Electrical Fault Detection and Protection
West China Hospital of Sichuan University
2019-2024
Sichuan University
2019-2024
First Affiliated Hospital of Fujian Medical University
2023-2024
Fujian Medical University
2023-2024
Nanjing University
2024
Qinghai University
2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2023
The Ohio State University
2007-2023
The Engineering & Technical College of Chengdu University of Technology
2023
Chengdu University of Technology
2023
Diapause, the dormancy common to overwintering insects, evokes a unique pattern of gene expression. In flesh fly, most, but not all, fly's heat shock proteins (Hsps) are up-regulated. The diapause up-regulated Hsps include two members Hsp70 family, one member Hsp60 family (TCP-1), at least four small Hsp and pseudogene. Expression an cognate, Hsc70 , is uninfluenced by diapause, Hsp90 actually down-regulated during thus differs from stress responses that elicit synchronous up-regulation all...
Inflammatory bowel disease (IBD) is defined as an immune dysregulation with poor prognosis. Various therapies based on gut microbe modulation have been proposed. In this study, we aim to explore the therapeutic effect of B. adolescentis IBD, well and microecology mechanism in IBD. The fecal level was decreased IBD patients compared normal people our cohort GMrepo database. To further clarify role induced chronic colitis three cycles dextran sulfate sodium (DSS). We found gavage exhibited...
The role of type I collagen, composed collagen alpha 1 (COL1A1) and 2 (COL1A2), has been studied in several cancers. However, the expression COL1A1 COL1A2 malignant, premalignant, normal gastric tissues their clinical significances cancer have not elucidated. Real-time quantitative PCR was performed 55 27 19 to measure messenger RNA (mRNA) expression, correlations between clinicopathological parameters patients' survival rate were analyzed. We found that mRNA significantly upregulated...
To explore the structure and composition of fecal microbiota patients with epilepsy.Variations in between epilepsy healthy controls (HCs) from same household were investigated validated by utilizing 16S ribosomal RNA sequencing two independent cohorts [exploration cohort (N = 55 N 46 HCs) validation 13 10 HCs)].The alpha diversity indexes specimens much lower than those HCs (p < 0.05). The differed different clinical prognoses (Adonis: p Microbiome alterations included increases...
<h3>Objective</h3> To study the factors associated with relapse and functional outcomes in patients anti-NMDA receptor encephalitis Western China. <h3>Methods</h3> The Outcome of Encephalitis Study China was initiated October 2011 to collect prospective observational data from consecutively enrolled encephalitis. <h3>Results</h3> We 244 (median age: 26 years, range: 9–78 years; females: 128 [52.45%]) between September 2019. Fatality occurred 17 (6.96%) patients, tumors were found 38 (15.57%)...
Objective: To measure mortality, identify predictors of death and investigate causes in patients with anti-gamma-aminobutyric-acid B receptor (anti-GABABR) encephalitis. Methods: Prospective analysis anti-GABABR encephalitis cases diagnosed between June 2013 August 2018 West China Hospital Sichuan University, assessment factors associated mortality. Results: A total 28 (11 females) were included this study. After a maximum time 52 months (median 11 months, range 2-52) follow-up, 9 (32.1%)...
Abstract Objective This study was undertaken to update and evaluate long‐term seizure outcomes in patients with autoimmune encephalitis (AE) based on a large cohort long follow‐up. Methods In this prospective observational registry study, we analyzed data from AE mediated by common types of neuronal surface antibodies (anti‐ N ‐methyl‐ d ‐aspartate receptor [NMDAR], anti‐leucine‐rich glioma‐inactivated 1 [LGI1]/contactin‐associated protein‐like 2 [Caspr2], anti‐γ‐aminobutyric acid type B...
The current work aims to explore the suitable drying technique for peanut pods which can be used seeds or edible peanuts. Four methods, namely naturally-open sun as control check (CK), hot air (HAD), pulsed vacuum (PVD), and radio frequency combined (RF-HAD), were employed dry pods, their effects on nutritional quality attributes in terms of protein, fat, fatty acid contents, etc., germination characteristics, microstructure, color, texture, value peroxide peanuts explored. Mathematical...
To study the clinical characteristics of anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis and anti-contactin-associated protein-like 2 (Caspr2) to investigate factors associated with poor long-term neurological functional outcomes relapse among patients in western China.In this single-center prospective cohort study, we consecutively enrolled anti-LGI1 anti-Caspr2 from April 2014 February 2021. Patient were assessed using modified Rankin scale. Predictors analyzed.Forty-four...
To analyze the cost of autoimmune encephalitis (AE) in China for first time.Patients who were newly diagnosed with antibody-positive AE (anti-NMDA receptor [NMDAR], anti-γ aminobutyric acid type B [GABABR], antileucine-rich glioma-inactivated 1 [LGI1], and anticontactin-associated protein-2 [CASPR2]) at West Medical Center between June 2012 December 2018 enrolled, a cost-of-illness study was performed retrospectively. Data on clinical characteristics, costs, utilization sources collected...
Artificial intelligence models tailored to diagnose cognitive impairment have shown excellent results. However, it is unclear whether large linguistic can rival specialized by text alone.
Abstract Background AI models tailored to diagnose cognitive impairment have shown excellent results. However, it is unclear whether large linguistic can rival specialized by text alone. Objectives We would explore the effectiveness of ChatGPT for primary screening mild (MCI) and standardize design steps components prompt. Methods obtained 174 participants from DementiaBank classified 70% them into training set 30% test set. Three dimensions variables were incorporated, including:...
Objective We aimed to investigate the associations between intestinal microbiota, metabolites, cytokines, and clinical severity in anti- N -methyl- d -aspartate receptor (NMDAR) encephalitis further determine predictive value of microbiota or metabolites prognosis. Methods In this prospective observational cohort study 58 NMDAR patients 49 healthy controls, fecal cytokines were quantified characterized by16S rRNA gene sequencing, liquid chromatography–mass spectrometry, Luminex assay,...
Abstract Desiccation presents a major challenge for the Antarctic midge, Belgica antarctica . In this study, we use proteomic profiling to evaluate protein changes in larvae elicited by dehydration and rehydration. Larvae were desiccated at 75% relative humidity (RH) 12 h achieve body water loss of 35%, approximately half that can be lost before succumb dehydration. To rehydration response, first desiccated, then rehydrated 6 100% RH h. Controls held continuously RH. Protein analysis was...
Abstract Objective To explore the diversity and composition of fecal microbiota in patients with anti‐ N ‐methyl‐ D ‐aspartate receptor (NMDAR) encephalitis. Methods We enrolled 10 acute stage naïve treatment, seven relapse, 13 without relapse remission phase, 12 paired healthy controls. The different groups was compared by 16S ribosomal DNA (rDNA) gene pyrosequencing. Results Prominent dysbiosis gut microbiome anti‐NMDAR encephalitis found. Our primary findings showed that overall species...