A5100755557- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Cytomegalovirus and herpesvirus research
- Genetics and Neurodevelopmental Disorders
- Infectious Encephalopathies and Encephalitis
- Herpesvirus Infections and Treatments
- Adenosine and Purinergic Signaling
- Genetic Mapping and Diversity in Plants and Animals
- Polyomavirus and related diseases
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic diversity and population structure
- Advanced MRI Techniques and Applications
- Migraine and Headache Studies
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- Neurological disorders and treatments
- Multiple Sclerosis Research Studies
- Chronic Disease Management Strategies
- Neuroinflammation and Neurodegeneration Mechanisms
- Glycogen Storage Diseases and Myoclonus
- Neurological and metabolic disorders
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2023-2025
Community Health Center
2024
Baoding People's Hospital
2021-2024
Mianyang Central Hospital
2024
University of Electronic Science and Technology of China
2024
Affiliated Hospital of Southwest Medical University
2024
Hangzhou Normal University
2020-2023
China People's Police University
2011-2022
To clarify the anatomical organization of human memory remains a major challenge in clinical neuroscience. Experimental data suggest dentate gyrus granule cells play role acquisition, i.e. pattern separation and rapid completion, whereas hippocampal CA1 neurons are implicated place autobiographical retrieval. Patients with temporal lobe epilepsy present broad spectrum impairment, which can be assessed during examination. Although long seizure histories may contribute to pathophysiological...
Psychogenic non-epileptic seizures (PNES) are paroxysmal behaviors that resemble epileptic but lack abnormal electrical activity. Recent studies suggest aberrant functional connectivity involving specific brain regions in PNES. Little is known, however, about alterations of topological organization whole-brain and structural networks We constructed from resting-state MRI signal correlations diffusion tensor imaging tractography 17 PNES patients 20 healthy controls. Graph theoretical analysis...
<h3>Objective:</h3> To examine the potential efficacy of statin treatment in reducing risk poststroke seizures. <h3>Methods:</h3> In this cohort study, patients with a first-ever ischemic stroke and no history epilepsy before were enrolled. After mean follow-up period 2.5 years, assessment was performed to identify epilepsy. Logistic regression Cox analyses used assess relationship between use early-onset seizures or <h3>Results:</h3> Of 1,832 enrolled patients, 63 (3.4%) had 91 (5.0%)...
Predicting the risk of falls in advance can benefit quality care and potentially reduce mortality morbidity older population. The aim this study was to construct validate an electronic health record-based fall predictive tool identify elders at a higher falls.The one-year prediction model developed using machine-learning-based algorithm, XGBoost, tested on independent validation cohort. data were collected from records (EHR) Maine 2016 2018, comprising 265,225 patients (≥65 years age).This...
Background:The imbalance in healthcare between urban and rural areas is still a problem China. In recent decades, China has aimed to develop telemedicine. We assessed the implementation, utilization, cost-effectiveness of large telemedicine program across western China.Materials Methods:In 2002–2013, government-sponsored major was established by West Hospital Sichuan University (hub), covering 249 spoke hospitals 112 cities throughout 40 medical expertise areas. analyzed cross-sectional data...
Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was analyze the correlation between MMP-14 expression and clinicopathologic features its prognostic significance non-small cell lung cancer (NSCLC). Immunohistochemical staining for protein performed 104 patients with NSCLC. High levels were positively correlated status clinical stage (I-II vs. III-IV; P < 0.001), N classification (N0-N1 N2-N3; distant metastasis...
Objective: Autoimmune encephalitis associated with antibodies against gamma-aminobutyric-acid B receptor (GABABR) has not been described in detail Chinese patients. Methods: Patients anti-GABABR treated between January 2013 and December 2015 were analyzed terms of clinical characteristics, laboratory findings, tumor presence, autoantibody patterns, treatment response outcomes. Results: Eleven patients identified (male, N = 8; female, 3), the median age 51 years. All presented seizures (N 11;...
This study reported a case of overlapping anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and myelin oligodendrocyte glycoprotein (MOG) inflammatory demyelinating disease with human herpesviruses 7 (HHV-7) infection.The detailed clinical characteristics, neuroimaging features, outcomes the patient were collected. Polymerase chain reaction (PCR), cell-based assay (CBA) tissue-based indirect immunofluorescence (TBA) used for diagnosis.The manifestations included headache, dizziness,...
<title>Abstract</title> Background Headache is one of the most common comorbidities in epilepsy, with affected patients experiencing various types headaches. This study aimed to investigate differences comorbid headache across epilepsy origins, comparing pain levels among multiple types, and exploring associations between characteristics prognosis. Methods We retrospectively analyzed consecutive adult headache, collecting comprehensive sociodemographic, epilepsy-related, headache-related...
Abstract Objective Data on seizure and pregnancy outcomes in Asian women with epilepsy are limited. We used a Chinese registry to assess the impact of seizures antiseizure medications (ASMs) pregnant their children. Methods This is an ongoing prospective multicenter study that has been running since 2012. Eligible participants were consecutively enrolled had multiple follow‐ups up one year after delivery. assessed ASM use frequency during establish potential effects mothers infants identify...
Ofatumumab presents a potentially promising alternative to current second-line immunotherapy for refractory anti-N-methyl-D-aspartate receptor autoimmune encephalitis (NMDAR-AE). We aimed evaluate the efficacy and safety of ofatumumab as novel NMDAR-AE. This prospective, multicenter, nested cohort study compared patients with NMDAR-AE from CHina Autoimmune encephalitiS outcomE registry (CHASE) recruited between October 2011 February 2024, treated without ofatumumab. The primary outcome was...
Background Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is a severe autoimmune disorder with high morbidity and mortality. Current treatments have limitations including relapse, highlighting the need for effective maintenance therapy. This study evaluates efficacy safety of mycophenolate mofetil (MMF) as long-term adjunctive therapy to first-line treatment in newly diagnosed patients NMDARE. Methods We conducted prospective, randomised, open-label trial four academic centres...
Abstract Background Dissociative seizures (DS), also known as psychogenic non-epileptic (PNES), often mimic epileptic (ES), leading to misdiagnosis, unnecessary anti-seizure medications (ASMs)/ suboptimal use of ASMs, and delays in appropriate care approximately one-third patients. Rare presentations, such episodes resembling oculogyric crisis (OGC), further complicate differentiation. This report highlights the diagnostic challenges DS with atypical features emphasises role...
Abstract Objective We aimed to assess the prevalence, clinical characteristics, and risk factors for psychosis in a cohort of people with epilepsy West China. Methods used retrospective information from databases three tertiary centers, which included follow‐up records 2006 onward. Those complete baseline data at least one record were included. A psychiatrist confirmed diagnosis psychosis. Psychiatric features evaluated using Brief Rating Scale, Scale Assessment Positive Symptoms, Negative...
β‑amyloid precursor protein (β‑APP), also known as Aβ peptide, has a key role in the pathogenesis of Alzheimer's disease, and is likely to be involved development refractory epilepsy. The mechanism behind association between β‑APP epilepsy remains elucidated. aim present study was examine levels APP mRNA patients with Tissue samples were obtained from chronic pharmacoresistant who underwent surgery. Levels epileptic temporal lobe hippocampal tissue assessed using quantitative polymerase...