A5074257147- Epilepsy research and treatment
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Colorectal and Anal Carcinomas
- Intraocular Surgery and Lenses
- Inflammatory mediators and NSAID effects
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Eicosanoids and Hypertension Pharmacology
- COVID-19 and Mental Health
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- COVID-19 Clinical Research Studies
- Colorectal Cancer Treatments and Studies
Sichuan University
2023-2025
West China Hospital of Sichuan University
2023-2025
Michigan Center for Translational Pathology
2024
University of Michigan
2016-2024
University College London
2024
National Hospital for Neurology and Neurosurgery
2024
Epilepsy Society
2024
Zhejiang Chinese Medical University
2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2023
Michigan Cancer Research Consortium
2018
The perivascular adipose tissue (PVAT) surrounding vessels constitutes a distinct functional integral layer of the vasculature required to preserve vascular tone under physiological conditions. However, there is little information on relationship between PVAT and blood pressure regulation, including its potential contributions circadian variation.Using unique brown adipocyte-specific aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) angiotensinogen knockout mice, we...
Objective— Perivascular adipose tissue (PVAT) contributes to vascular homeostasis by producing paracrine factors. Previously, we reported that selective deletion of PPARγ (peroxisome proliferator-activated receptor γ) in smooth muscle cells resulted concurrent loss PVAT and enhanced atherosclerosis mice. To address the causal relationship between atherosclerosis, used BA-PPARγ-KO (brown adipocyte-specific knockout) Approach Results— Deletion brown adipocytes did not affect white or PPARα...
Abstract Objective Several antiseizure medications (ASMs) have been approved for the treatment of focal epilepsy. However, there is a paucity evidence on direct comparison ASMs. We evaluated comparative efficacy and safety all add‐on ASMs epilepsy using network meta‐analysis. Methods Data through extensive literature search was retrieved from PubMed, Embase, Cochrane, ClinicalTrial.gov databases predefined terms inception March 2023. PRISMA reporting guidelines (CRD42023403450) were followed...
Abstract Objective Data on seizure and pregnancy outcomes in Asian women with epilepsy are limited. We used a Chinese registry to assess the impact of seizures antiseizure medications (ASMs) pregnant their children. Methods This is an ongoing prospective multicenter study that has been running since 2012. Eligible participants were consecutively enrolled had multiple follow‐ups up one year after delivery. assessed ASM use frequency during establish potential effects mothers infants identify...
Abstract Background and purpose The aim was to investigate the neurological complications associated with coronavirus disease 19 (COVID‐19) during 2022 Omicron wave. Methods analysis medical records of a cohort people admitted wards three participating tertiary centres in Sichuan from 12 December January 2023 were reviewed. Demographics clinical data obtained analysed an interest COVID‐19‐related new‐onset or worse symptoms. current also compared two similar same period months earlier....
Background: Perivascular adipose tissue (PVAT), which surrounds most vessels, is de facto a distinct functional vascular layer actively contributing to function and dysfunction. PVAT contributes aortic remodeling by producing releasing large number of undetermined or less characterized factors that could target endothelial cells smooth muscle cells, herein contribute the maintenance vessel homeostasis. Loss in mice enhances atherosclerosis, but causal relationship between atherosclerosis...
Abstract Objective Using Optical coherence tomography (OCT), we evaluated the association between peripapillary retinal nerve fiber, macular thickness, ganglion cell‐inner plexiform layer, and drug resistance. Methods In this cross‐sectional study, recruited people diagnosed with epilepsy healthy controls. People were further stratified as drug‐resistant or non‐drug‐resistant based on their response to anti‐seizure medications. OCT measurements conducted, findings in right eye analyzed....
Abstract Background Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is typically resistant to pharmacological interventions; however, achieving seizure freedom possible through surgery. Our objective was focus on the pregnancy and outcomes during of women TLE-HS, aim identify predictors control. Methods The West China Registry Pregnancy Women Epilepsy (WCPR_EPi) a monocentric prospective cohort study (WWE). We screened TLE-HS in this database. Their clinical profile, anti-seizure...