A5103231429- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Biofuel production and bioconversion
- Receptor Mechanisms and Signaling
- Statistical Methods in Clinical Trials
- Enzyme Production and Characterization
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Plant-based Medicinal Research
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Ion channel regulation and function
- Cerebrovascular and Carotid Artery Diseases
- Microbial Metabolic Engineering and Bioproduction
- Cardiac pacing and defibrillation studies
- Metabolism, Diabetes, and Cancer
- Allergic Rhinitis and Sensitization
- Pathogenesis and Treatment of Hiccups
- Colonialism, slavery, and trade
- Agricultural and Food Sciences
- Healthcare during COVID-19 Pandemic
Technion – Israel Institute of Technology
2018-2024
VIB-KU Leuven Center for Cancer Biology
2024
KU Leuven
2024
The University of Melbourne
2024
Instituto Politécnico de Leiria
2019-2023
Polytechnic Institute of Viana do Castelo
2021
University of Florida
2018-2020
Columbus Oncology and Hematology Associates
2018-2020
St George's, University of London
2016-2019
National University of Ireland
2009-2010
The D2 /D3 antagonist amisulpride has shown promising efficacy against postoperative nausea and vomiting (PONV) at low doses. We investigated whether intravenous an effect on the QTc interval in a formal Thorough QT study (TQT).This was randomized, double-blind, placebo positive-controlled, four-way crossover study. Forty healthy Caucasian Japanese subjects were included to receive single administration of 5 mg 40 i.v. or oral dose moxifloxacin per period.The therapeutic associated with...
Most UK hospitals, laboratories, and research institutions use uniform reference intervals (RI) that do not take into account known diurnal racial variation in total white blood cells (WBC) count its constituent parameters. These risks of excluding potentially suitable ethnic minority volunteers from participating phase I clinical trials could call question the validity a trial's findings or limit scientific applications ability to accurately observe drug effects upon WBC This study pools...
Women are associated with longer electrocardiographic QT intervals and increased proarrhythmic risks of QT-prolonging drugs. The purpose this study was to characterize the differences in cardiac electrophysiology between moxifloxacin levofloxacin men women assess balance inward outward currents through analysis subintervals. Data from 2 TQT studies were used investigate impact (400 mg) (1000 1500 on subintervals using algorithms for measurement J-Tpeak Tpeak -Tend intervals....
OBE022, a new orally active prostaglandin F
Rupatadine is a marketed second generation antihistamine, with anti-PAF activity, indicated for symptomatic treatment of allergic rhinitis and urticaria. This study was conducted to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety tolerability rupatadine in healthy Japanese subjects after single multiple oral doses.In this randomised, double-blind, placebo-controlled study, 27 male female were administered escalating dose 10, 20 40 mg or placebo. Blood samples collected at...
The purpose of this study was to compare the external load, internal and technical efficacy between first second matches (M1 M2) occurring in congested fixtures (two two days) using number sets as a moderating factor. An observational analytic research design adopted. Data from official volleyball were collected during competitive period championship, comprising 14 games within 10 weeks. Ten male elite athletes (age: 21.7 ± 4.19 years age; experience: 6.2 3.8 years; body mass: 85.7 8.69 kg;...
Meal intake leads to a significant and prolonged increase in cardiac output supply the splanchnic vasculature. A meal is associated with sympathetic activation of cardiovascular system, food ingestion correlated an heart rate, stroke volume, QTc interval shortening for up 7 hours. Given complexity one or several many mechanisms could explain this observation. The was rise C-peptide following ingestion, but by which may be involved modulation repolarization are still unknown. This myocardial...
Textile effluents are highly polluting and have variable complex compositions. They can be extremely complex, with high salt concentrations alkaline pHs. A fixed-bed bioreactor was used in the present study to simulate a textile effluent treatment, where white-rot fungus, Trametes versicolor, efficiently decolourised azo dye Reactive Black 5 over 28 days. This occurred under conditions, which is unusual, but advantageous, for successful decolourisation processes. Active maintained by...
The thermostable enzyme systems produced by the thermophilic ascomycete fungus Talaromyces emersonii cultivated on various carbon sources were investigated for production of high value products from sugar beet. A broad range enzymatic activities relevant to cellulose, hemicellulose, and pectin hydrolysis identified in T. culture filtrates. In experiments conducted at 71ºC, cocktails generated sugar-rich syrups untreated beet plants. Maximal levels obtained with induced sorghum/ pulp (68%)...
Abstract Understanding the physiological fluctuations in corrected QT (QTc) interval is important to accurately interpret variations drug‐induced prolongation. The present study aimed define time course of effect moxifloxacin on understand duration responses moxifloxacin. This retrospective analysis was performed data taken from a thorough 4‐way crossover with 40 subjects. Each period consisted baseline electrocardiogram (ECG) day (day –1) and treatment 1). On both days, ECGs were recorded...
Non-alcoholic fatty liver disease (NAFLD) affects nearly one third of the population worldwide. Understanding metabolic pathways involved can provide insights into progression. Untargeted metabolomics livers from mice with early-stage steatosis indicated a decrease in methylated metabolites suggesting altered carbon metabolism. The levels glycine, central component metabolism, were lower steatotic mice, line clinical evidence. Isotope tracing studies demonstrated that increased synthesis...
A thorough QT/QTc study in healthy white Caucasian subjects demonstrated that rupatadine has no proarrhythmic potential and raised cardiac safety concerns. The present phase 1 aimed to confirm the of Japanese subjects. In this randomized, double-blind, placebo-controlled study, 27 were administered single multiple escalating doses 10, 20, 40 mg or placebo. Triplicate electrocardiogram (ECG) recordings performed on days -1, 1, 5 at several points, time-matched pharmacokinetic samples also...
Background The assessment of QTc changes after the intake a standardized meal has been proposed as an alternative approach to prove assay sensitivity when proarrhythimic potential drug is be excluded in either TQT or intensive Phase I QT studies. Methods In this article, analysis food effect at baseline across periods two different studies presented support robustness method. Results results show that time‐effect attributed stable over study demonstrating consistency physiological response...
Abstract The most recent International Conference on Harmonisation E14 Q&A document states that a separate positive control would not be necessary provided sufficiently high exposures are achieved in the early‐phase studies. Realistically, phase 1 study is unlikely to include pharmacological control, and cases which plasma levels of drug exceeding therapeutic achieved, lack can constitute limitation when excluding an effect regulatory concern. It has been proposed use standardized meal...
There is a well-established association between atrial fibrillation (AF) and coronary artery disease. Coronary calcium score (CACS) helpful tool to refine cardiovascular (CV) risk stratification inform on the best strategies for primary CV prevention. This study aims evaluate impact of opportunistic screening with CACS decision preventive therapies, in patients AF.Cross-sectional including AF or flutter undergoing cardiac computed tomography ablation procedure planning, from 2017 2019....
Transient cortical blindness (TCB) is an uncommon complication following coronary angiography. This report describes a case of TCB after angiography in patient admitted for acute myocardial infarction. The patient's vision recovered completely within 16 h, and cardiac magnetic resonance imaging performed 2 months later revealed no significant abnormalities. (Level Difficulty: Beginner.)
In December 2015, the International Conference of Harmonization (ICH) E14 guideline generated guidance on how exposure-response modelling can be used to characterise potential for a drug affect cardiac repolarisation and modulate QTc interval.The released Q&A document describes data from Phase I ascending dose SAD MAD studies in right circumstances accepted by regulatory bodies as an alternative approach TQT demonstrate safety.While this strategy is now being expanded all new drugs, analysis...
In eighteenth-century fiction and drama, race appears as a mutable characteristic, with skin color conditioned by culture environment. Increasingly, especially in the Romantic period, came to be regarded an inherent facet of person's identity certain contexts. Racialized color-charts emerged for express purpose generating taxonomy mixed-race peoples; symptom vogue classification natural sciences. These charts encoded vocabulary gradation, hybridity, racial inheritance. Such was mapped on...