Abstract Actual use studies play a key part in evaluating the reduced risk potential of tobacco and nicotine products. This study was undertaken to determine puffing topography, mouth level exposure (MLE) average daily consumption (ADC) relating two commercially available heating products (THPs) prototype electronic cigarette (or e-cigarette) among Italian non-mentholated 7 mg ISO tar smokers. The conducted Milan, Italy, with three groups approximately 50 participants. Groups 1 3 included...

Abstract With the rapidly rising popularity and substantial evolution of electronic cigarettes (e-cigarettes) in past 5–6 years, how these devices are used by vapers consumers’ exposure to aerosol emissions need be understood. We puffing topography measure directly product use. adapted a cigarette device for use with e-cigarettes. performed validation using air e-cigarette under multiple regimes. Consumer was measured 60 provided rechargeable “cig-a-like” or larger button-activated...

Summary Providing data on usage patterns is key to assessing the reduced-risk potential of novel tobacco and nicotine products as compared conventional cigarettes at a population level. A pilot cross-sectional survey was conducted in 2018 across 3 areas Japan (Tokyo, Osaka, Sendai) assess product use after introduction Heated Tobacco Products (HTPs). Following successful completion study, two nationwide surveys were using general HTPs. The first (Wave 1) 2019, second 2020. In Wave 2, concern...

Summary Exclusive use of Swedish snus is associated with a reduction in health risks as compared cigarette smoking. Similar to but without tobacco, modern oral nicotine pouches are smokeless products the potential offer similar or greater reductions tobacco use. Currently, little known about prevalence these established markets for snus. In this descriptive study, two market research surveys were conducted 2019 among 18–64-year-olds Sweden (n = 7003; male, 51.1%) and Denmark 4402; 50.5%) on...

The tobacco heating product THP1.0, which heats but does not burn tobacco, was tested as part of a modified-risk assessment framework for its impacts on indoor air quality and residual smoke odour. THP1.0 the to less than 240 °C ± 5 during puffs. An environmentally controlled room used simulate ventilation conditions corresponding residential, office hospitality environments. analysis known constituents, included CO, CO2, NO, NO2, nicotine, glycerol, 3-ethenyl pyridine, sixteen polycyclic...

For novel tobacco products that potentially reduce the risk of harm, post-market surveillance is important to observe population usage and behaviours associated with everyday use. This pilot study was performed examine use in three Japanese urban regions.

A four-arm study was undertaken in Japan to determine the puffing topography, mouth level exposure and average daily consumption by consumers of tobacco heating products (THPs): non-mentholated THP1.0(T), mentholated THP1.0(M) a system (THS). The extent lip blocking air inlet holes while using THP1.0(T) also assessed. Groups 1, 2, 4 included smokers, group 3 regular THP users. Smokers 7-8 mg ISO nicotine free dry particulate matter (NFDPM) cigarettes took on larger mean puff volumes from...

This series of nine papers described the operation and pre-clinical assessment a tobacco heating product THP1.0. last paper contextualises data on THP1.0 with from other next generation products relative to cigarette smoke. The nicotine risk continuum is concept that ranks according their potential harm, cigarettes at highest extreme Nicotine Replacement Therapy least risky extreme. Data generated in studies range Next Generation Products (NGPs) may provide some initial indication ranking...

Women are associated with longer electrocardiographic QT intervals and increased proarrhythmic risks of QT-prolonging drugs. The purpose this study was to characterize the differences in cardiac electrophysiology between moxifloxacin levofloxacin men women assess balance inward outward currents through analysis subintervals. Data from 2 TQT studies were used investigate impact (400 mg) (1000 1500 on subintervals using algorithms for measurement J-Tpeak Tpeak -Tend intervals....

Menthol can reduce sensory irritation and it has been hypothesised that this could result in smokers of mentholated cigarettes taking larger puffs deeper post-puff inhalations thereby obtaining higher exposures to smoke constituents than non-mentholated cigarettes. The aim our study was use part-filter analysis methodology assess the effects cigarette menthol loading on regular occasional We measured mouth level exposure tar nicotine investigated mentholation smokers' perceptions such as...

Differences in length and circumference of cigarettes may influence smoker behaviour exposure to smoke constituents. Superslim king-size (KSSS) (17mm versus 25mm conventional [KS] cigarettes), have gained popularity several countries, including Russia. Some constituents are lower machine-smoked KSSS KS cigarettes, but few data exist on actual smokers. We investigated mouth-level (MLE) tar nicotine Russian smokers measured under machine-smoking conditions. MLE was similar for 1mg ISO yield...

Cigarette filter ventilation allows air to be drawn into the filter, diluting cigarette smoke. Although machine smoking reveals that toxicant yields are reduced, it does not predict human yields. The objective of this study was investigate relationship between and mouth level exposure (MLE) tar nicotine in smokers. We collated reviewed data from 11 studies across 9 countries, performed 2005 2013 which contained on MLE 156 products with 0% 87%. among 7534 participants estimated using...

A study was performed to determine whether cigarettes were smoked more intensely outside of public venues in Scotland, compared indoors, after introduction the place smoking (PPS) ban. It conducted three waves: before ban, immediately and 6 months introduction. The included 322 regular smokers four cigarette brand variants. Filter analysis measurements used estimate human-smoked yields tar nicotine from predominantly inside (before ban) or (after venues. Self-reported consumption data also...

Abstract Filter analysis methodology can be used to estimate smokers’ mouth level exposure (MLE) ‘tar’ and nicotine from spent cigarette filters. Variation in smoking behaviour design are known have an impact on the range of MLE. Most ‘King Size’ (KS) cigarettes a circumference about 25 mm 83-84 long, with filters 20-27 length. Recently, slimmer format, described as Size Superslim’ (KSSS), 17 mm, has become popular several countries. Although studies estimated MLE smokers KS cigarettes,...

Objective: In this study, we obtained key population-level data on use patterns and behavior relating to tobacco nicotine products in Japan. Methods: We performed a nationwide cross-sectional survey of the general population Japan 2019 assess after introduction heating (THPs). Eligible participants were Japanese residents, aged 20 years or older who consented complete survey. Individuals living institutions excluded. A 3-stage probability sampling method was applied that geographically...

Summary Respiratory deposition from smoking articles is influenced by particle or droplet properties (such as diameter), puffing parameters draw effort pressure drop, flow rate, duration), mouth losses, and post-puff inhalation dynamics (determined depth, volume breath hold duration). The Smoking Behaviour System (SBS) described herein a novel system with regard to its capability measure duration characteristics of typical cycles, which may consist puffing, hold, inhalation, exhalation. It...

<p class="abstract">Due to the novel nature of oral nicotine pouches, limited studies have been conducted on usage these products in real-world settings. Consumption patterns and use behaviour current pouch users need be investigated monitor support assessment reduced risk products. Here we report findings an online survey completed by 550 participants across Sweden, Denmark, Germany Switzerland who were users. The key areas research history, mouth hold duration, strength, average...