A5038686753- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Cholesterol and Lipid Metabolism
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Cynara cardunculus studies
- Paraoxonase enzyme and polymorphisms
- Advanced Proteomics Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Liver Disease and Transplantation
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Pomegranate: compositions and health benefits
- Mitochondrial Function and Pathology
- Body Composition Measurement Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
Louisiana State University Health Sciences Center Shreveport
2021-2025
Louisiana State University
2022-2025
University of Michigan–Ann Arbor
2017-2024
Louisiana State University Health Sciences Center New Orleans
2024
Louisiana State University in Shreveport
2023-2024
Michigan Center for Translational Pathology
2020-2022
Michigan Medicine
2019-2021
Ann Arbor VA Medical Center
2020
Technion – Israel Institute of Technology
2012-2017
Rambam Health Care Campus
2017
A glycine- and leucine-based tripeptide improves symptoms in a mouse model of nonalcoholic fatty liver disease, which lacks approved treatments.
The term sarcopenia describes the loss of skeletal muscle mass, strength, and function in old age. As world population continues to grow older, more attention is given phenomena search for strategies prevention treatment. progression affected by age-related physiological systemic changes body, including alterations tissue, hormonal changes, increased inflammatory activities, oxidative stress. Sarcopenia also lifestyle factors which are far controllable. These include various aspects...
Background: Abdominal aortic aneurysm (AAA) is a severe disease with high mortality rate in the event of rupture. Pharmacological therapy needed to inhibit AAA expansion and prevent Transcription factor EB (TFEB), master regulator autophagy lysosome biogenesis, critical maintain cell homeostasis. In this study, we aim investigate role vascular smooth muscle (VSMC) TFEB development establish as novel target treat AAA. Methods: The expression was measured human mouse samples. We used...
Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need identify new targetable pathways. Dysregulated glycine metabolism has emerged as causative factor therapeutic target NASH. Here, we report that tripeptide DT-109 (Gly-Gly-Leu) dose-dependently attenuates fibrosis mice. To enhance probability...
Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated (NO2-CLA). Herein, NO2-CLA generation demonstrated within context acute inflammatory responses both in vitro and vivo. Macrophage activation resulted dose- time-dependent CLA also production secondary electrophilic non-electrophilic derivatives. Both exogenous as well that generated situ, attenuated NF-κB-dependent gene expression, decreased pro-inflammatory...
Objective— Perivascular adipose tissue (PVAT) contributes to vascular homeostasis by producing paracrine factors. Previously, we reported that selective deletion of PPARγ (peroxisome proliferator-activated receptor γ) in smooth muscle cells resulted concurrent loss PVAT and enhanced atherosclerosis mice. To address the causal relationship between atherosclerosis, used BA-PPARγ-KO (brown adipocyte-specific knockout) Approach Results— Deletion brown adipocytes did not affect white or PPARα...
Abstract Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses participants in HUNT Study Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related disease, but detrimental function. We 76 (11 previously unreported) presumed causal...
BackgroundNonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools effective therapies constitute two the major hurdles for a bona fide treatment reversal NASH progression and/or regression disease. Nitro-oleic acid (OA-NO2) has been proven in multiple experimental models inflammation fibrosis. Thus, potential benefit vivo administration OA-NO2 to treat advanced NAFLD was tested...
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, unique subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, critical for cardiac and skeletal myogenesis, yet little known about its function in vasculature and, specifically, AAA pathogenesis. Here, we found that BAF60c was downregulated human mouse tissues, with primary staining to smooth muscle cells (VSMCs), confirmed by single-cell RNA-sequencing. In vivo studies revealed...
Lower circulating levels of glycine are consistently reported in association with cardiovascular disease (CVD), but the causative role and therapeutic potential atherosclerosis, underlying cause most CVDs, remain to be established. Here, following identification reduced patients significant coronary artery (sCAD), we investigated a atherosclerosis by modulating availability atheroprone mice. We further evaluated atheroprotective DT-109, recently identified glycine-based compound dual...
Impairments in carbohydrate, lipid, and amino acid metabolism drive features of plaque instability. However, where these impairments occur within the atheroma remains largely unknown. Therefore, we sought to characterize spatial distribution metabolites stable unstable atherosclerosis both fibrous cap necrotic core.