A5017048405- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Bioactive Compounds in Plants
- Essential Oils and Antimicrobial Activity
- Chromatography in Natural Products
- Bioactive natural compounds
- Phytochemical compounds biological activities
- Membrane Separation and Gas Transport
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Flavonoids in Medical Research
- Postharvest Quality and Shelf Life Management
- Spinal Fractures and Fixation Techniques
- Extraction and Separation Processes
- Plant biochemistry and biosynthesis
- Head and Neck Surgical Oncology
- Synthesis and properties of polymers
- Medicinal Plant Pharmacodynamics Research
- Process Optimization and Integration
- Molecular Junctions and Nanostructures
- Silicone and Siloxane Chemistry
- Photopolymerization techniques and applications
- Chemistry and Chemical Engineering
Henan Institute of Geological Survey
2025
Guangzhou Medical University
2013-2024
State Key Laboratory of Respiratory Disease
2019-2024
Changhai Hospital
2024
Second Military Medical University
2024
Linyi People's Hospital
2021
Guangdong Pharmaceutical University
2012-2019
Sun Yat-sen University
2009-2017
Stomatology Hospital
2017
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2017
Abstract To discriminate the feasible differences and find potential similarities relationships of Citri Reticulatae Pericarpium ( CRP ), this work was accomplished by a comprehensive reliable method using gas chromatography–mass spectrometer GC – MS ) to analyze volatile oils high‐performance liquid chromatography HPLC simultaneously determine contents five bioactive flavonoids, namely hesperidin, nobiletin, 3,5,6,7,8,3′,4′‐heptamethoxyflavone, tangeretin,...
The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
The Citrus reticulata 'Chachi' pericarp (CRCP) is one cultivar of Citri Reticulatae Pericarpium (Chenpi), which widely applied in medicine and food. To determine the potential value CRCP harvested at different stages subjected to drying processes, dynamic changes bioactive components were profiled evaluated this study.The contents all non-volatile components, i.e. synephrine, limonin, phenolic acids flavonoids, decreased with delayed harvest time. volatiles thujene, α-pinene, β-pinene,...
To systematically analyze the chemical constituents of Citri Sarcodactylis Fructus (CSF) from different origins, an efficient approach based on ultraperformance liquid chromatography plus Q-Exactive Orbitrap tandem mass spectrometry (UPLC-Q-Exactive Orbitrap/MS) detection for discrimination components 15 batches CSF four main origins was used in this research. Through parent peaks, fragment fragmentation characteristics, and comparative analysis with literature reference standards, a total...
Abstract Gas chromatograph–mass spectrometer (GC–MS), ultra‐high‐performance liquid chromatograph‐Q‐Exactive Orbitrap tandem mass spectrometry (UHPLC‐Q‐Exactive Orbitrap‐MS), and high‐performance chromatography–photodiode array detection (HPLC–PDA) were used to qualitatively quantitatively analyze the chemical component of Citri Reticulatae Pericarpium Viride “Geqingpi” (GQP). First all, volatile components GQP are identified by GC–MS. Totally 56 determined, γ‐Terpinene (33.39%) D‐Limonene...
Abstract Citrus reticulata semen, a traditional Chinese medicinal material, has desirable and dietary properties. In this study, method combining ultra high performance liquid chromatography with Q Exactive Orbitrap tandem mass spectrometry was established validated for the identification analysis of chemical components C. semen first time. The evaluation different retention times fragmentation characteristics, as well comparative literature, resulted in 35 constituents, including 21...
In this study, a pH-responsive nano-prodrug was fabricated by conjugating emodin to the PEGylated polyethyleneimine (mPEG-PEI) with acid-sensitive boronate ester bonds. 1H NMR spectra results showed that effectively bonded mPEG-PEI, and assay further confirmed formation of The size morphology were ascertained through transmission electron microscopy (TEM) dynamic light scattering (DLS), which prodrug has sphere-like shape hydrodynamic around 102 nm at pH 7.4. Subsequently, drug-release...
Limonin is a natural tetracyclic triterpenoid compound in citrus seeds that presents hepatoprotective effects but often discarded as agricultural waste because of its low content and solubility. Herein, limonin with high purity (98.11%) from was obtained via purification by high-speed counter-current chromatography (HSCCC) recrystallization. Limonin-loaded liposomes (Lip-LM) prepared thin film hydration pressure homogenization method to enhance solubility effect on APAP-induced liver injury...
ABSTRACT Traditional Chinese medicine formula granules (TCMFGs) are the advanced dosage forms of single traditional herbal decoction pieces, which widely used for clinical treatment in China. With application TCMFG, Erchen (ECD), a classic (TCM) treating phlegm–dampness syndrome, is treated as TCM instead herb pieces. However, chemical profiles and consistency between ECD pieces still unclear. To clarify ECD, ultra‐high performance liquid chromatography‐Q‐Exactive Orbitrap tandem mass...
To evaluate the quality of Pericarpium Citri Reticulatae from China, a new, simple, and accurate method involving high-performance liquid chromatography with dual wavelength detection was developed for simultaneous determination five bioactive flavonoids, hesperidin, nobiletin, 3,5,6,7,8,3′,4′-heptamethoxyflavone, tangeretin, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone first time. Under optimal condition, analysis performed on Dikma Diamonsil C18 column gradient elution solvent system...
To thoroughly evaluate the quality of Citri Sarcodactylis Fructus (CSF) and acquire knowledge lipophilic components CSF from different origins, a simple efficient approach based on supercritical fluid extraction (SFE) combined with ultraperformance liquid chromatography plus Q-Exactive Orbitrap tandem mass spectrometry (UPLC-Q-Exactive Orbitrap/MS) detection for discrimination was set up first time in this work. Eight batches samples five main producing areas were extracted by SFE under...
Epigallocatechin-3-gallate (EGCG), a frequently studied catechin in green tea, has been shown involved the anti-proliferation and apoptosis of human nasopharyngeal carcinoma (NPC) cells. However, underlying molecular mechanism apoptotic effects EGCG not fully investigated. Recent literature emphasized importance Sirtuin 1 (SIRT1), an NAD+-dependent protein deacetylase, regulating cellular stress responses, survival, organismal lifespan. Herein, study showed that could significantly inhibit...
Abstract To systematically identify the lipophilic constituents of Citri Reticulatae Pericarpium from different cultivars, supercritical CO 2 fluid extraction and ultra‐high‐performance liquid chromatography–Q Exactive Orbitrap tandem mass spectrometry were integrated for component analysis 18 batches 12 cultivars first time. A total 57 components extracts demonstrably or tentatively identified by obtained parent peaks, fragment retention times. In total, two flavonoids, six organic acids,...