A5101577615- Heme Oxygenase-1 and Carbon Monoxide
- Traditional Chinese Medicine Studies
- Neonatal Health and Biochemistry
- Connexins and lens biology
- High Altitude and Hypoxia
- Sphingolipid Metabolism and Signaling
- Cancer Risks and Factors
- Meta-analysis and systematic reviews
- Neurological Disease Mechanisms and Treatments
- Infant Nutrition and Health
- Inflammatory mediators and NSAID effects
- Pain Management and Placebo Effect
- Electrochemical sensors and biosensors
- Gut microbiota and health
- Colorectal Cancer Surgical Treatments
- Migraine and Headache Studies
- Advanced Chemical Sensor Technologies
- Colorectal Cancer Screening and Detection
- Ginseng Biological Effects and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Global Cancer Incidence and Screening
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
First Affiliated Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Guangzhou University of Chinese Medicine
2015-2023
Guangdong Academy of Medical Sciences
2018-2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2018-2020
Guangzhou University
2018
Fudan University
2014
Zhongshan Hospital
2014
The metabolite of ginsenosides, compound K improves memory and cognitive dysfunction in diabetes mellitus mice.
Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects been used to treat cardiovascular cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection cerebral ischemia remain unclear. The interaction between nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed molecular docking study, showed that selectively binds NOX2 with high...
The objective of the current study is to investigate effect PTGS2 on proliferation, migration, angiogenesis and apoptosis endothelial progenitor cells (EPCs) in mice with ischemic stroke through NF-κB signaling pathway. Middle cerebral artery occlusion (MCAO) model was established mice. EPCs were identified, which ectopic expression depletion experiments conducted. mRNA protein related factors tissues measured. Besides, angiogenesis, apoptosis, as well cell cycle distribution, determined....
Abstract The aberrant expression of lncRNAs has been inferred to be closely related with the progression neural ischemia/reperfusion (I/R) injury. RMRP is an lncRNA associated I/R In order determine role in injury, effects knockdown on oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced injury SH-SY5Y cells were evaluated. effect OGD/R administration and apoptosis cells, suppression by siRNA impairments proliferation mobility potential due assessed current study. At molecular level,...
Background Data on the association between serum bilirubin and risk of stroke are limited inconclusive. We aimed to evaluate first examine any possible effect modifiers in hypertensive patients. Methods Results Our study was a post hoc analysis CSPPT (China Stroke Primary Prevention Trial). A total 19 906 patients were included final analysis. Cox proportional hazards models used estimate hazard ratios (HRs) 95% CIs for associated with levels. The median follow‐up period 4.5 years. When...
Background. Ischemic stroke (IS) seriously impacts the quality of life survivors. Chinese medicine (CM) has been developed for more than 2000 years and plays a key role in treatment ischemic stroke. Many clinical trials have conducted; however, heterogeneity outcome measurements reporting limits implications findings practice health policy development. Therefore, it is important to develop core set (COS) that should be used reported treated by medicine. This protocol describes process...
Abstract Background PREDICT is a web-based tool for forecasting breast cancer outcomes. version 3.0 was recently released. This study aimed to validate this large population in mainland China and compare v3.0 with v2.2. Methods Women who underwent surgery nonmetastatic primary invasive between 2010 2020 from the First Affiliated Hospital of Wenzhou Medical University were selected. Predicted observed 5-year overall survival (OS) both v2.2 compared. Discrimination compared using...
Aims This study aimed to investigate the association between gut microbiota and risk of stroke. Methods Faecal samples from 60 participants in South China, including 45 individuals with factors for stroke 15 healthy controls, were collected subjected 16S rRNA sequencing. A bioinformatics analysis was performed characterise microbial diversity taxonomic compositions at different levels (low, moderate, high) Functional prediction correlation analyses laboratory markers explore potential...
Background Ado-trastuzumab emtansine (T-DM1) is prescribed for HER2-positive, metastatic breast cancer or early after neoadjuvant therapy. Although several adverse events (AEs) have been reported, there remains a need comprehensive evaluation of its safety profile.
Introduction Tension-type headache (TTH) is the most prevalent neurological disease, with an estimated 1.5 billion cases worldwide. Pharmacotherapy should be considered by patients TTH who have a limited response to non-pharmacological treatment. However, recommendations for vast array of therapeutic drugs partially overlap, conflicting strength in different guidelines; these may confuse decision-making process clinicians. Hence, aims this study are analyse available direct and indirect...
Background: Identification of novel risk factors is essential to further lower stroke risk. Data concerning the relation serum bilirubin levels with are limited. We sought evaluate association between and first in hypertensive patients.Methods: Our analyses included a total 19,906 patients from China Stroke Primary Prevention Trial (CSPPT). In CSPPT, 20,702 without major cardiovascular diseases were randomly assigned double-blind, daily treatment either 10mg enalapril 0·8mg folic acid or 10...
Background: Data concerning the association between serum bilirubin and risk of stroke is limited inconclusive. We aimed to evaluate first stroke, examine any possible effect modifiers in hypertensive patients.Methods: Our analyses included a total 19,906 patients from China Stroke Primary Prevention Trial (CSPPT). In CSPPT, 20,702 without major cardiovascular diseases were randomly assigned double-blind, daily treatment with either 10mg enalapril 0·8mg folic acid or 10 mg alone. The median...