A5051307940- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Malaria Research and Control
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Circular RNAs in diseases
- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Orthopaedic implants and arthroplasty
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV/AIDS drug development and treatment
- Advanced Photocatalysis Techniques
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Poxvirus research and outbreaks
- Metabolism, Diabetes, and Cancer
Foshan University
2020-2025
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2021-2023
Guilin University of Technology
2023
Wuzhou University
2023
East China University of Science and Technology
2019-2022
China Medical University
2015-2021
State Key Laboratory of Respiratory Disease
2011-2019
Chinese Academy of Sciences
2011-2019
Guangzhou Institutes of Biomedicine and Health
2013-2019
Shanxi University
2017
Abstract Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H 2 O ) production and catalase H degradation, which serves as an intracellular regulator to degrade toxic peroxides water. Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy integrating lactate oxidase (LOx) (CAT) into Fe 3 4 nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated FIGs-LC). Based on...
Abstract Background MicroRNAs (miRNAs) are a large class of tiny non-coding RNAs (~22-24 nt) that regulate diverse biological processes at the posttranscriptional level by controlling mRNA stability or translation. As molecular switch, canonical Wnt/β-catenin signaling pathway should be suppressed during adipogenesis; However, activation this leads to inhibition lipid depots formation. The aim our studies was identify miRNAs might involved in adipogenesis modulating WNT pathway. Here we...
Understanding the dynamics of muscle transcriptome during development and between breeds differing in growth is necessary to uncover complex mechanism underlying development. Herein, we present first transcriptome-wide longissimus dorsi research concerning Lantang (LT, obese) Landrace (LR, lean) pig 10 time-points from 35 days-post-coitus (dpc) 180 days-post-natum (dpn) using Solexa/Illumina's Genome Analyzer. The data demonstrated that myogenesis was almost completed before 77 dpc, but...
Porcine reproductive and respiratory syndrome (PRRS) has been one of the most economically important diseases affecting swine industry worldwide causes great economic losses each year. PRRS virus (PRRSV) replicates mainly in porcine alveolar macrophages (PAMs) dendritic cells (DCs) develops persistent infections, antibody-dependent enhancement (ADE), interstitial pneumonia immunosuppression. But molecular mechanisms PRRSV infection still are poorly understood. Here we report on first...
Abstract Pursuing and developing effective methodologies to construct highly active catalytic sites maximize the atomic energy efficiency by material engineering are attractive. Relative tremendous researches of carbon-based single atom systems, construction bio-applicable materials is still in its infancy. Herein, we propose a facile general interfacial-confined coordination strategy high-quality single-atom nanotherapeutic agent with Fe atoms being anchored on defective carbon dots...
There was a large scale outbreak of the highly pathogenic porcine reproductive and respiratory syndrome (PRRS) in China Vietnam during 2006 2007 that resulted unusually high morbidity mortality among pigs all ages. The mechanisms underlying molecular pathogenesis virulent PRRS virus (H-PRRSV) remains unknown. Therefore, relationship between pulmonary gene expression profiles after H-PRRSV infection pathology were analyzed this study using high-throughput deep sequencing...
Summary The innate immune response provides the initial defence mechanism against infection by other organisms. However, an excessive will cause damage to host tissues. In attempt identify microRNAs (miRNAs) that regulate in inflammation and homeostasis, we examined differential expression of miRNAs using microarray analysis spleens mice injected intraperitoneally with lipopolysaccharide (LPS) saline, respectively. Following challenge, observed 19 up‐regulated (1·5‐fold) LPS. Among these...
Abstract Lung cancer is the world's leading cause of cancer‐related morbidity and mortality despite advances in surgery, chemotherapy immunotherapy; thus, there an urgent need to find new molecules develop novel treatment strategies. Although ncRNAs were found account for 98% transcripts, number lncRNAs with distinct function lung extremely limited. We previously demonstrated that Plasmodium infection inhibits tumour growth metastasis, but exact mechanisms involved have not been fully...
C-C chemokine receptor type 5 (CCR5) is a major co-receptor for the entry of human immunodeficiency virus type-1 (HIV-1) into target cells. Human hematopoietic stem cells (hHSCs) with naturally occurring CCR5 deletions (Δ32) or artificially disrupted have shown potential curing acquired syndrome (AIDS). However, Δ32 donors are scarce, heterologous bone marrow transplantation not exempt risks, and genetic engineering autologous hHSCs trivial. Here, we locus embryonic (hESCs) induced...
Lung cancer is the leading cause of deaths worldwide; study microRNAs gives new hope for lung treatment. miR-411 has been demonstrated to be an independent prognostic factor adenocarcinoma, but role and regulatory mechanism are largely unknown. In present study, we found was overexpressed in cells; overexpression promoted anchorage-dependent anchorage-independent growths cancer, while knockdown reduced this effect. Further showed forkhead box O1 (FOXO1) a target miR-411. Overexpression...
A major challenge in the development of effective cancer immunotherapy is ability tumors and their microenvironment to suppress immune cells through immunosuppressive such as myeloid -derived suppressor regulatory T cells. We previously demonstrated that Plasmodium infection promotes innate adaptive immunity against a murine Lewis lung model but its effects on tumor are unknown. Whole Tumors tumor-derived sorted from tumor-bearing mice treated with or without plasmodium infected red blood...
Given the threat of drug resistance, there is an acute need for new classes antimalarial agents that act via a unique mechanism action relative to currently used drugs. We have identified set druglike compounds within Tres Cantos Anti-Malarial Set (TCAMS) which likely inhibition Plasmodium aspartic protease. Structure–activity relationship analysis and optimization these aminohydantoins demonstrate are potent nanomolar inhibitors proteases PM-II PM-IV one or more other proteases....
Recently, the therapeutic efficacy of reactive oxygen species (ROS)‐mediated photodynamic therapy (PDT) involving laser irradiation or chemodynamic (CDT) has been limited by low penetration depth and insufficient O 2 supply in PDT modest ROS production CDT. To address these, a facile “reductant‐free reduction” strategy is developed to construct smart tumor microenvironment (TME)/near‐infrared dual‐responsive hybrid nanoplatform, consisting up‐conversion nanoparticles (UCNPs) photosensitizer...
Neuroinflammation has emerged as an important cause of cognitive decline during aging and in Alzheimer's disease (AD). Chronic low-grade inflammation is observed obesity diabetes, which are risk factors for AD. Therefore, we examined the markers brain hippocampal samples Zucker diabetic fatty (ZDF) rats. Pathway-specific gene expression profiling revealed significant increases oxidative stress inflammatory genes. Western blot analysis further showed activation NF-kB, defective CREB...
We have previously demonstrated that malaria parasite infection has an anti-tumor effect in a mouse model. This research aimed to investigate the possibility of using Plasmodium as novel vaccine vector for hepatocellular carcinoma (HCC) immunotherapy. constructed yoelii 17XNL strain (P.y) expressing murine glypican-3 (GPC3) protein (P.y-GPC3), and examined its therapeutic potency Hepa1-6-induced hepatoma model highly expressed GPC3 protein. The prerequisites invoking CD8+ T cell response...
Communications between neurons and glial cells play an important role in regulating homeostasis the central nervous system. cAMP response element-binding protein (CREB), a transcription factor, is down-regulated by neurotoxins, which are known to be released activated cells. To determine of CREB signaling neuroglial interactions, we used three coculture models consisting human neuroprogenitor cell (NPC)-derived microglia. Conditioned medium from Abeta (Aβ)-activated microglia decreased...
Given their highly adjustable and predictable properties, three-dimensional(3D) printed geometrically ordered porous biomaterials offer unique opportunities as orthopedic implants. The performance of such is, however, much a result the surface properties struts it is 3D structure. In our previous study, we have investigated in vitro performances selective laser melted (SLM) Ti-6Al-4V scaffolds which are modified by bioactive glass (BG) mesoporous (MBG), respectively. results demonstrated...