A5101515905- Bone Tissue Engineering Materials
- Titanium Alloys Microstructure and Properties
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Ultrasound and Hyperthermia Applications
- Microstructure and Mechanical Properties of Steels
- Advanced ceramic materials synthesis
- Mesenchymal stem cell research
- RNA Research and Splicing
- Tendon Structure and Treatment
- RNA modifications and cancer
- Welding Techniques and Residual Stresses
- Concrete and Cement Materials Research
- Advanced materials and composites
- Lung Cancer Treatments and Mutations
- Hippo pathway signaling and YAP/TAZ
- Tribology and Wear Analysis
- Blood properties and coagulation
- Planarian Biology and Electrostimulation
- Metal and Thin Film Mechanics
- Fibroblast Growth Factor Research
- Antimicrobial agents and applications
- Geotechnical Engineering and Soil Mechanics
- Anatomy and Medical Technology
- Ferroptosis and cancer prognosis
China Medical University
2014-2024
Fourth Affiliated Hospital of Guangxi Medical University
2024
Chinese PLA General Hospital
2024
Taiyuan University of Technology
2024
Hohai University
2023
Harbin Institute of Technology
2008-2013
Abstract Mechanobiological stimuli, such as low-intensity pulsed ultrasound (LIPUS), have been shown to promote bone regeneration and fresh fracture repair, but the fundamental biophysical mechanisms involved remain elusive. Here, we propose that a mechanosensitive ion channel of Piezo1 plays pivotal role in noninvasive ultrasound-induced mechanical transduction pathway trigger downstream cellular signal processes. This study aims investigate expression MC3T3-E1 cells after LIPUS treatment....
Developing bioactive materials for bone implants to enhance healing and growth has years been the focus of clinical research. Barium titanate (BT) is an electroactive material that can generate electrical signals in response applied mechanical forces. In this study, a BT piezoelectric ceramic coating was synthesized on surface TC4 titanium alloy, forming BT/TC4 material, low-intensity pulsed ultrasound (LIPUS) then as stimulus. The combined effects biological responses MC3T3-E1 cells were...
Concerns over the use of autografts or allografts have necessitated development biomaterials for bone regeneration. Various studies been performed to optimize cultivation osteogenic cells using osteoconductive porous scaffolds. The aim this study was evaluate efficiency cell ingrowth, proliferation, and early differentiation in a silicon carbide (SiC) ceramic scaffold promoted with low-intensity pulsed ultrasound. MC3T3-E1 mouse preosteoblasts were seeded onto scaffolds cultured 4 7 days...
Antibacterial abilities and biocompatibilities of Ti-Ag alloys with nanotubular coatings Xingwang Liu,1 Ang Tian,2 Junhua You,3 Hangzhou Zhang,4 Lin Wu,5 Xizhuang Bai,1 Zeming Lei,1 Xiaoguo Shi,2 Xiangxin Xue,2 Hanning Wang4 1Department Orthopedics, The People’s Hospital China Medical University, 2Liaoning Provincial Universities Key Laboratory Boron Resource Ecological Utilization Technology Materials, Northeastern 3School Materials Science Engineering, Shenyang University Technology,...
Given their highly adjustable and predictable properties, three-dimensional(3D) printed geometrically ordered porous biomaterials offer unique opportunities as orthopedic implants. The performance of such is, however, much a result the surface properties struts it is 3D structure. In our previous study, we have investigated in vitro performances selective laser melted (SLM) Ti-6Al-4V scaffolds which are modified by bioactive glass (BG) mesoporous (MBG), respectively. results demonstrated...
Objectives Low‐intensity pulsed ultrasound (LIPUS) combined with porous scaffolds can be used as a new therapy to treat bone defect repair. The aim of this study was evaluate the effects 1 and 3.2 MHz LIPUS on osteogenesis Ti64 alloy for both in vitro vivo studies. Methods Scaffolds were randomly divided into high‐frequency group, low‐frequency control group. Mouse pre‐osteoblast cells cultured Ti‐6Al‐4V cell proliferation differentiation. In addition, implanted rabbit mandibular defects...
Background: Implant-related infection is a major problem postsurgery. As an alternative to localized antibiotic release system, we used Ag fabricate Ti–Ag alloys with nanotubular coatings (TiAg-NTs). has excellent antibacterial properties, but its biological toxicity concern. Therefore, performed experiments both in vitro and vivo evaluate the biocompatibility of TiAg-NTs different concentrations (1%, 2%, 4%). Methods: For experiments, cytocompatibility, including cell attachment, viability,...
Porous Ti-6Al-4V scaffold materials can be used to heal massive bone defects because they provide space for vascularisation and formation. During new tissue development, rapid vascular ingrowth into is very important. Osteoblast-derived exosomes are capable of facilitating angiogenesis-osteogenesis coupling. Low-intensity pulsed ultrasound (LIPUS) a physical therapy modality widely utilised in the field regeneration has been proven enhance production functionality on two-dimensional...
Abstract Background Molecular mechanism of lung squamous cell carcinoma (LUSC) remains poorly understood, hampering effective targeted therapies or precision diagnosis about LUSC. We devised an integrative framework to investigate on the molecular patterns LUSC by systematically mining genomic, transcriptional and clinical information. Methods utilized genomics transcriptomics data for cohorts in The Cancer Genome Atlas.. Both kinds omics 33 types cancers were downloaded from NCI’s Genomic...
This study was to evaluate the effects of low-intensity collimated pulse ultrasound (LICU) and focused-pulse (LIFU) stimulation on osteogenesis in porous silicon carbide (SiC) scaffold implanted rabbit mandible.Rabbits were randomly divided into LIFU group, LICU group control (without treatment). The intensities 30 300 mW/cm2, respectively. subcutaneous subperiosteal temperatures measured continuously during 20-min treatment. Then, SiC scaffolds mandible, followed by or once daily, quantity...
The objective of this study was to investigate the possibility silicon carbide (SiC) foam as an alternative material for porous hydroxyapatite (HA). characters two materials were evaluated and compared by a series in vitro biological tests. result morphology showed that SiC provided beneficial structure cell migration. On level primary-osteoblasts proliferation measured MTT assay cycle analysis rate increased early stage on HA but advanced foam. There no significant difference between...
<title>Abstract</title> Background The clinical application of stem cells in restoring ischemic lower limb perfusion has been hindered by challenges. To promote the directed differentiation mesenchymal cells(MSCs) into endothelial cells(ECs) and enhance paracrine effect, this paper aim to find a combined therapy for angiogenesis. Methods MSCs based on Hyaluronic Acid(HA) hydrogel with GM-CSF IL-2(HGI-MSCs) were locally injected femoral artery ligated ischemia model rat. Recovery was assessed...