A5065792760- Malaria Research and Control
- HIV/AIDS drug development and treatment
- Drug-Induced Hepatotoxicity and Protection
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Crystallization and Solubility Studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- X-ray Diffraction in Crystallography
- Invertebrate Immune Response Mechanisms
Michigan State University
2019-2024
Saint Louis University
2015-2019
Identification of novel chemotypes with antimalarial efficacy is imperative to combat the rise Plasmodium species resistant current drugs. We have used a hybrid target-phenotype approach identify and evaluate for malaria. In our search drug-like aspartic protease inhibitors in publicly available phenotypic databases, we identified GNF-Pf-4691, 4-aryl- N-benzylpyrrolidine-3-carboxamide, as having structure reminiscent known proteases. Extensive profiling two terminal aryl rings revealed...
infection can trigger high levels of inflammation that lead to fever and sometimes severe disease. People living in malaria-endemic areas gradually develop resistance symptomatic malaria control both parasite numbers the inflammatory response. We previously found adaptive natural killer (NK) cells correlate with reduced load protection from symptoms. also murine NK cell production IL-10 protect mice experimental cerebral malaria. Human secrete IL-10, but it was unknown what subsets produce...
Current World Health Organization guidelines for conducting anti-malarial drug efficacy clinical trials recommend genotyping Plasmodium falciparum genes msp1 and msp2 to distinguish recrudescence from reinfection. A more recently developed potential alternative this method is a molecular assay based on panel of 24 single nucleotide polymorphism (SNP) markers. Performance parameters these two methods were compared using data completed trials. Blood samples therapeutic analysed by both msp the...