A5077686081- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Genetic factors in colorectal cancer
- Chromium effects and bioremediation
- Circular RNAs in diseases
- Neuropeptides and Animal Physiology
- Aquaculture disease management and microbiota
- Complex Systems and Time Series Analysis
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Financial Markets and Investment Strategies
Shanghai Institute of Materia Medica
2022-2025
Fudan University
2023-2025
Chinese Academy of Sciences
2022-2024
Southwest University
2022-2024
Shenyang Pharmaceutical University
2022-2023
Nanchang University
2022-2023
State Key Laboratory of Drug Research
2022
Second Affiliated Hospital of Nanchang University
2022
Wuhan University
2021
Background Various tumors are insensitive to immune checkpoint blockade (ICB) therapy. Toll-like receptors (TLRs) establish the link between innate and adaptive immunity, which can assist T-cell activation serve as promising targets for combination enhance ICB Here, we aimed improve efficacy anti-programmed death ligand 1 (PD-L1) therapy by developing a PD-L1/TLR7 dual-targeting nanobody-drug conjugate (NDC), based on PD-L1 nanobodies TLR7 agonist developed. Methods were obtained phage...
With the increasing bacterial resistance to traditional antibiotics, there is an urgent need for development of alternative drugs or adjuvants antibiotics enhance antibacterial efficiency. The combination antimicrobial peptides (AMPs) and a potential In this study, we investigated synergistic bactericidal effect AMPs, including chicken (CATH-1,-2,-3, -B1), mice (CRAMP), porcine (PMAP-36 PR-39) in with conventional containing ampicillin, tetracycline, gentamicin, erythromycin against...
The increase in the emergence of antimicrobial resistance has led to great challenges controlling porcine extraintestinal pathogenic Escherichia coli (ExPEC) infections. Combinations peptides (AMPs) and antibiotics can synergistically improve efficacy reduce bacterial resistance. In this study, we investigated antibacterial activity myeloid peptide 36 (PMAP-36) combination with tetracycline against ExPEC PCN033 both vitro vivo. minimum bactericidal concentrations (MBCs) AMPs (PMAP-36 PR-39)...
Abstract Cancer cells employ various mechanisms to evade immune surveillance. Their surface features, including a protective “sugar coat” and checkpoints like PD-L1 (programmed death ligand 1), can impede cell recognition. Sialic acids, which carry negative charges, may hinder contact through electrostatic repulsion, while transmits immunosuppressive signals T cells. Furthermore, cancer manipulate macrophages within the tumor microenvironment facilitate escape. Prior research has...
This article investigates the impact of firm-specific investor sentiment on stock price synchronicity and further examines relationship between crash risk. By analysing dataset Chinese market, we find that higher induces lower synchronicity, which is inconsistent with argument supported by a majority previous studies low represents high informativeness. We also negative future risk, supporting view in an irrational less return comovement not associated more information but noise.
Abstract CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is known to be a regulator of membranal programmed death ligand 1 (PD-L1) stability and factor associated with malignancy progression, but the effects mechanisms CMTM6 on tumor growth, as well its potential target for therapy, are still largely unknown. Here, we show that expression increased progression in both patients mice. Ablation significantly reduced human murine growth manner dependent T-cell immunity. Tumor...
SUMMARY Highlights B cells participate in anti-tumor immunity by influencing the intratumoral infiltration and function of T cells; CMTM6 cis-interacts with CD40 inhibits ubiquitin/proteasome-mediated degradation to maintain cell membrane levels; Loss cell-intrinsic significantly reduces signaling-mediated activation, survival, differentiation, T/B interaction immunity; deficiency leads a significant reduction activity agonists ICB therapy. In Brief Long et al. demonstrate that B-cell...
Abstract The increased emergence of antimicrobial resistance brings great challenges in controlling porcine extraintestinal pathogenic Escherichia coli (ExPEC) infections. Combinations peptides (AMPs) and antibiotics can synergistically improve efficacy reduce bacterial resistance. This study investigated the antibacterial activity myeloid peptide 36 (PMAP-36) combination with tetracycline against ExPEC PCN033 both vitro vivo . We found that MBCs AMPs (PMAP-36 PR-39) strains RS218 were 10 μM...
<div>Abstract<p>CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is known to be a regulator of membranal programmed death ligand 1 (PD-L1) stability and factor associated with malignancy progression, but the effects mechanisms CMTM6 on tumor growth, as well its potential target for therapy, are still largely unknown. Here, we show that expression increased progression in both patients mice. Ablation significantly reduced human murine growth manner dependent...
<p>Supplementary Table and Figures S1-S21</p>
<div>Abstract<p>CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is known to be a regulator of membranal programmed death ligand 1 (PD-L1) stability and factor associated with malignancy progression, but the effects mechanisms CMTM6 on tumor growth, as well its potential target for therapy, are still largely unknown. Here, we show that expression increased progression in both patients mice. Ablation significantly reduced human murine growth manner dependent...
<p>Supplementary Table and Figures S1-S21</p>
Abstract Inhibin beta A (INHBA) and its homodimer activin have pleiotropic effects on modulation of immune responses tumor progression, respectively, but it remains uncertain whether tumors may release to regulate anti-tumor immunity. As evidenced by our RNA-Seq in vitro results, the interferon-γ (IFN-γ) signaling pathway was significantly down-regulated intrinsic A. Tumor INHBA deficiency led lower expression PD-L1 induced IFN-γ, resulting poor responsiveness anti-PD-L1 therapy. On other...
Abstract CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) has been identified as a regulator of membranal programmed death ligand 1 (PD-L1) stability and factor associated with malignancy progression, but the effects mechanisms CMTM6 on tumor growth, well its potential for therapy, are still largely unknown. Here, we show that increased progression in both clinical patients mice. Ablation resulted significant retardation human murine growth dependent T-lymphocyte immunity. Tumor...
Difficulties in obtaining stable full-length PD-L1 and CMTM6 membrane proteins hinder the investigation of their structures, functions, drug development. Here, using cell mimetic strategy, we have screened lauryl maltose neopentyl glycol (LMNG) as an optimized detergent assembled a membrane-bound CMTM6-PD-L1 complex with amphipol A8-35. Analyzing PD-1/PD-L1-CMTM6 interactions, was found to enhance binding attenuate dissociation PD-1/PD-L1 affect immunosuppressive signaling anti-apoptotic...