A5101714014- interferon and immune responses
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- RNA Research and Splicing
- TGF-β signaling in diseases
- Osteoarthritis Treatment and Mechanisms
- Ubiquitin and proteasome pathways
- RNA regulation and disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Salmonella and Campylobacter epidemiology
- Clostridium difficile and Clostridium perfringens research
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Herbal Medicine Research Studies
- Nigella sativa pharmacological applications
- Veterinary Equine Medical Research
- Peripheral Neuropathies and Disorders
- Reproductive Biology and Fertility
- Patient Satisfaction in Healthcare
- NF-κB Signaling Pathways
Hebei Medical University
2025
Xingtai People's Hospital
2025
Nanfang Hospital
2023
Southern Medical University
2023
Sichuan Agricultural University
2017-2021
Chinese Academy of Agricultural Sciences
2015
Huazhong University of Science and Technology
2014
Previous studies have indicated that bone morphogenetic protein (BMP) 6 may play an important role in skeletal system development and progression. However, the mechanism underlying effects of BMP6 cartilage cell proliferation differentiation remains unknown. In this study, cells were isolated from shanks chicken embryos treated with different concentrations Growth Hormone. Cell potential was assessed using real-time polymerase chain reaction (RT-PCR), western blotting CCK-8 assays vitro. The...
In order to breed new birds with strong disease resistance, it is necessary first understand the mechanism of avian antiviral response. Interferon regulatory factor 7 (IRF7) not only a member type I interferons (IFNs) (IRFs) family, but also major regulator IFN response in mammals. However, whether IRF7 involved host innate immune remains unclear poultry, due absence IRF3. Here, we observed by HE stains that increase time ALV-J challenge, thymus was obviously loose and swollen, arrangement...
TRAF family member-associated NF-κB activator (TANK)-binding kinase1 (TBK1) is a serine-threonine kinase at the crossroads of multiple interferon (IFN)-inducing signaling pathways in innate immunity. The importance TBK1 antiviral immunity well established mammal models, but chicken, molecular characterization and potential function remain unclear. In present study, open-reading frame (ORF) chicken (chTBK1) was cloned characterized. sequencing results revealed that chTBK1 ORF consists 2190...
Avian leukosis virus subgroup J disease (ALV-J) is a contagious and immunosuppressive avian caused by ALV-J virus. Although miRNA participate in various biological processes of tumors, little known about the potential role ALV-J. Our previous RNA sequencing data showed that expression gga-miR-148a-5p was significantly different ALV-J-infected chicken spleens compared with non-infected chickens. The aim this study to investigate functional roles identify downstream targets regulated We found...
A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. logical extension of previous work, this study was conducted to investigate the expression plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and receptor (SP-R) in endometrium Sprague Dawley rats, New Zealand White rabbits, Macaca mulatta implanted with nano-Cu/LDPE composite. The influence composite on morphology also...
Avian leucosis (AL) is a disease characterized by tumors and caused the avian leukosis virus (ALV). Because of high variability viruses complex pathogenic mechanisms, screening breeding J subgroup ALV (ALV-J) resistant breeds one strategies for prevention treatment AL, thus significant immune markers needed to promote development disease-resistant breeds. In this study, data-independent acquisition (DIA) technology was used detect DEPs three chicken according different comparison investigate...
The melanocortin 1 receptor (MC1R) gene plays a key role in controlling the deposition of melanin. In mammals, MC1Rgene is regarded as major candidate control melanin formation. domestic animals, MC1R mainly controls expression coat, skin, and plumage color mammals birds. order to breed chickens with dark-green shank faster, we screened molecular markers for HS chicken population by exploring relationship between polymorphism three different colors (light green, dark green yellow). Two...
There is increasing evidence that bone morphogenetic protein 6 (BMP6) plays critical roles in regulating various stages of ovarian follicle development mammals. However, the mechanisms regulation BMP6 chicken ovary remain unclear. In this study, mRNA and expression level follicles at different were determined by qRT-PCR western blot separately. Different concentrations FSH added to culture medium, effects proliferation granulose cells detected, further effect on pattern progesterone...
Abstract Previous studies have indicated that bone morphogenetic protein (BMP) 6 plays an important role in skeletal system development and progression. However, the mechanism underlying effects of BMP6 cartilage cell proliferation differentiation remains unknown. In this study, cells were isolated from shanks chicken embryos treated with different concentrations GH. Cell potential was assessed using real-time polymerase chain reaction (RT-PCR) CCK-8 assays vitro. The results showed at 48 h,...
RNF11 (RING finger protein 11) has been indicated to be related numerous immunological diseases. As a neo-regulator in innate immunity, was proved inhibit antiviral signaling and interferon-β (IFN-β) production human cell line. Chicken pathway is different with other species. However, there little study about the role of chicken inflammatory response. This designed identify function We overexpressed interfered embryo fibroblasts (CEFs) then used quantitative reverse transcription polymerase...
Ubiquitin-specific protease 18 (USP18) is known as an inhibition factor and has been associated with the innate immune response to pathogens. USP18 only deconjugating specificity for interferon-stimulated gene 15 (ISG15), which supposed be missing in birds. To analyze efficacy of goose (goUSP18) against Tembusu virus (TMUV) infection, we first cloned homologous cDNA from TMUV infected geese. The coding sequence was 1131 bp, deduced amino acid shared conserved motifs its homologues....
Heparan sulfate proteoglycans (HSPGs) are present on the cell surface and in extracellular matrix all metazoans. HSPGs interact with growth factors receptors through heparan (HS) chains. The sulfation pattern of chains influences signaling events mediated by located surface. SULF1 SULF2 two endo-sulfatases that can cleave specific 6-O-sulfate groups within To determine their possible roles tissues satellite cells vitro, expression was examined from 40-day-old chickens breast muscles...
Abstract Background: The microbiota of the digestive and reproductive systems has a prominent role in animal health performance, but extent its contribution is difficult to determine. In chickens, effect host genetics on tract unclear, means by which digestive/reproductive microbiomes help improve egg production chicken are unknown. Results: To gain insight into this, we examined genomes from 128 chickens reared under identical conditions described their (crop, gizzard small intestine)...