A5100379313- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Garlic and Onion Studies
- CAR-T cell therapy research
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Cancer Cells and Metastasis
- Pomegranate: compositions and health benefits
- Bioactive Compounds and Antitumor Agents
- Nanoparticle-Based Drug Delivery
- Sunflower and Safflower Cultivation
- Postharvest Quality and Shelf Life Management
- Chemotherapy-induced organ toxicity mitigation
- Herpesvirus Infections and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Parvovirus B19 Infection Studies
- Rabbits: Nutrition, Reproduction, Health
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Nephrotoxicity and Medicinal Plants
- Nuclear Receptors and Signaling
- Pineapple and bromelain studies
China Pharmaceutical University
2025
Sichuan University
2003-2024
Carnegie Mellon University
2024
West China Second University Hospital of Sichuan University
2023-2024
State Key Laboratory of Biotherapy
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2018-2022
Sichuan Agricultural University
2007-2022
Wen's Food Group (China)
2018-2022
Nanjing University of Chinese Medicine
2014-2022
Fowl adenoviruses (FAdVs) are associated with many diseases, resulting in huge economic losses to the poultry industry worldwide. Since 2015, outbreaks of FAdV infections high mortality rates have been reported China. A continued surveillance FAdVs contributes understand epidemiology viruses.We isolated 155 strains from diseased chickens China between 2015 and 2018. PCR analysis determined that 123 samples were species C, 27 E, five contained two different strains. The phylogenetic...
Oncolytic virotherapy is a promising strategy for treatment of malignancy, although its effectiveness hampered by host antiviral inflammatory responses. The efficacy oncolytic vesicular stomatitis virus (VSV) in rats bearing multifocal hepatocellular carcinoma (HCC) can be substantially elevated antibody-mediated depletion natural killer (NK) cells. In order to test the hypothesis that oncotyic potency VSV exponentially evasion responses vivo, we constructed recombinant vector expressing...
Toll-like receptor (TLR) agonists as the potent stimulants of an innate immune system hold promises for applications in anticancer immunotherapy. However, most them are limited clinical translation due to uncontrolled systemic inflammatory response. In current study, 1V209, a small molecule TLR7 agonist, was conjugated with cholesterol (1V209-Cho) and prepared into liposomes (1V209-Cho-Lip). 1V209-Cho-Lip exerted minimal toxic effects enhanced transportation ability lymph nodes (LNs)...
Since a novel hyper-virulent fowl adenovirus serotype 4 (FAdV-4) infection occurred in 2015, the FAdV-4 has been widely spreading across China, causing significant economic losses to poultry industry. As urgency of issue calls for effective and efficient solutions, present study investigated possibility fiber-2 protein serve as vaccine candidate against FAdV-4. In research, proteins were expressed Escherichia coli, then purified. To evaluate immunogenicity recombinant protein, we both...
Abstract Glioblastoma is the most common primary tumor of central nervous system that develops chemotherapy resistance. Previous studies showed Allicin could inhibit multiple cancer cells including glioblastoma, but function in glioblastoma still unclear. Our work aimed to investigate underlying molecular mechanism. The results miR-486-3p levels were greatly increased during treatment. Overexpression chemosensitivity temozolomide (TMZ) vitro and vivo. O6-methylguanine-DNA methyltransferase...
RESEARCH HIGHLIGHTSFirst report of the epidemiology duck adenovirus 3 infection in China.Mutant DAdV-3 strains (truncated ORF67) became predominant.
Heat stress can impair the rabbit immune system, induce oxidative stress, and cause many complications. These diseases are characterized by metabolic disorders, but underlying mechanism is unknown. As a result, current research determines effects of HS on intestinal microorganisms in rabbits pathway disorders caused HS. Twelve were randomly assigned to one two groups: CON (22-24°C) (30°C-32°C). Both groups treated for 15 days. Blood fecal samples collected day 15. Serum oxidation indices...
Acute pancreatitis (AP) can be complicated by inflammatory disorders of remote organs, such as lung injury, in which Jumonji domain-containing protein 3 (JMJD3) plays a vital role proinflammatory responses. Currently, we found that JMJD3 expression was upregulated the pancreas and an AP male mouse model, also confirmed patients. Further experiments revealed upregulation effects were possibly exerted mitochondrial DNA (mtDNA) or oxidized-mtDNA from tissue injury caused AP. The release mtDNA...
Gene therapy on the basis of oncolytic adenovirus is a novel approach for human cancer therapeutics. We aim to investigate whether it will synergistically reinforce their antiovarian activities when combined use ZD55-manganese superoxide dismutase (MnSOD) and cisplatin was performed. The experiments in vitro showed that ZD55-MnSOD enhances cisplatin-induced apoptosis causes remarkable ovarian cell death. Apoptosis induction by treatment with and/or detected SKOV-3 apoptotic staining, flow...