A5044375656- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Photoacoustic and Ultrasonic Imaging
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- RNA Research and Splicing
- MXene and MAX Phase Materials
- Autophagy in Disease and Therapy
First Affiliated Hospital of Zhengzhou University
2015-2025
Zhengzhou University
2022-2024
Abstract Background Epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis with the involvement of microRNAs (miRNAs). This study aims to assess role miR-506 working tandem LIM Homeobox 2 (LHX2) EMT through Wnt/β-catenin signaling pathway nasopharyngeal carcinoma (NPC). Methods Differentially expressed genes associated NPC were screened using microarray analyses, from which LHX2 was identified. Next, potential relationship between...
Nasopharyngeal carcinoma (NPC) is a malignant epithelial cancer of the head and neck with high prevalence in southern China, which accompanied by notable invasiveness metastasis. Long noncoding RNAs (lncRNAs) participate progression various cancers including NPC. Microarray-based analysis identified highly expressed lncRNA mothers against decapentaplegic homolog 5 (SMAD5)-antisense RNA 1 (AS1) related to Interestingly, it found that SMAD5-AS1 competitively bound microRNA (miR)-106a-5p...
Abstract Microwave (MW) dynamic therapy (MDT) can efficiently eliminate tumor residue resulting from MW thermal therapy. However, MDT is currently in its infancy, and luck of effective sensiters severely limits clinical therapeutic effect. Herein, based on TiMOF (TM), a high‐efficiency sensitizer designed for thermo‐dynamic TM generate heat cytotoxic reacyive oxygen species (ROS) under irradiation has the potential to be used as an sensitizer, while suboptimal sensitization effect...
Objective: To explore the prognostic factors affecting patients with glioblastoma (GBM) treated Stupp regimen and establish a prediction model based on hematological indicators to guide future clinical decision - making. A total of 271 GBM meeting screening criteria were recruited. They randomly divided into training set (190 cases) validation (81 at 7:3 ratio. The was utilized comprehensive hematology scoring system (CHPSS), employed verify CHPSS. Risk Score (RS) computed from CHPSS,...
Abstract Background Breast cancer (BC) is the most common in women and second leading cause of cancer‐related deaths among worldwide. Single nucleotide polymorphisms (SNPs) cytokine genes have been shown to alter their expressions or functions patients with BC. In recent years, molecular structure function IL‐1 studied. Its genetic polymorphism could affect transcription expression gene. Moreover, it closely related several diseases. This fact plethora gene data prompted us investigate...
Acute pancreatitis (AP) can be complicated by inflammatory disorders of remote organs, such as lung injury, in which Jumonji domain-containing protein 3 (JMJD3) plays a vital role proinflammatory responses. Currently, we found that JMJD3 expression was upregulated the pancreas and an AP male mouse model, also confirmed patients. Further experiments revealed upregulation effects were possibly exerted mitochondrial DNA (mtDNA) or oxidized-mtDNA from tissue injury caused AP. The release mtDNA...
For the past few years, gene-therapy has recently shown considerable clinical benefit in cancer therapy, and applications of gene therapies treatments continue to increase perennially. EZH2, an ideal candidate for tumor plays important role tumorigenesis.In this study, we developed a novel delivery system with self-assembly method by Methoxy polyethylene glycol-polycaprolactone (MPEG-PCL) DOTAP(DMC). And EZH2si-DMC was used research anti-glioma both vitro vivo.DMC zeta-potential value 36.7...
Abstract Compelling evidence has indicated the vital role of lysine-specific demethylase 4 A (KDM4A), hypoxia-inducible factor-1α (HIF1α) and mechanistic target rapamycin (mTOR) signaling pathway in nasopharyngeal carcinoma (NPC). Therefore, we aimed to investigate whether KDM4A affects NPC progression by regulating HIF1α/DDIT4/mTOR pathway. First, adjacent tissue samples were collected, protein expression was examined immunohistochemistry. Then, interactions among KDM4A, HIF1α DDIT4...
Colorectal cancer is one of the most common and malignant in world wide. Recently, combination target therapy chemotherapy has generated new promise for colorectal cancer. Apatinib mesylate a novel highly selective VEGFR-2 inhibitor, presented with an outstanding activity anti-angiogensis, which potential treating various tumors. As traditional chemotherapeutic drug, docetaxel (Taxotere) widely used semisynthetic taxoid solid In this study, Liposome Methoxy poly(ethylene...
Abnormal long non-coding RNAs (lncRNAs) have been detected in esophageal squamous cell carcinoma (ESCC). Here, we focused on lncRNA ZNF667-AS1 and its downstream mechanism ESCC progression. Differentially expressed lncRNAs were predicted by bioinformatics analysis. ZNF667-AS1, microRNA-1290 (miR-1290), prune homolog 2 with BCH domain (PRUNE2) expression was determined their relationship biological processes analyzed also means of gain- loss-of-function assays. Xenograft mouse models...
Long non-coding RNAs (lncRNAs) have been widely highlighted due to their involvement in various types of cancers, including glioma; however, the exact mechanism and function by which they operate regard spinal cord glioma remain poorly understood. LOC101928963 was screened out for its differential expression microarray analysis. Therefore, this study conducted investigate modulatory effects on binding phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1). The characterized tissues,...
MicroRNA-155 is over-expressed in many human cancers, but researches on its association with malignant oesophageal squamous cell carcinoma (ESCC) are limited. The aim of the present study was to evaluate potential value miR-155 as a biomarker for ESCC diagnosis and prognosis. In this study, we found that significantly increased tissues compared paired adjacent healthy normal controls (p < .001), according qRT-PCR, which suggested might act an oncogene ESCC. addition, clinical features such...
Metastatic colorectal cancer is a stumbling block in management due to limited treatment approaches and unfavorable prognosis. Angiogenesis essential tumor development metastasis. Vascular endothelial growth factor receptor (VEGFR) targeted anti-angiogenesis drugs have gain inspiring achievements treatment. Apatinib novel small molecular VEGFR-2 tyrosine kinase drug with poor water-solubility, showing anti-tumor ability some solid tumors. In this study, PEG modified liposomal...
In recent decades, a large number of research studies have been conducted to improve the treatment strategy against epithelial ovarian cancer, but women in advanced stage still poor outcomes. The development treatments must be continued overcome limitation. Docetaxel, semi-synthetic product derived from Pacific Taxus extract, has studied for many years its potent anticancer applications. Aiming solve problems highly lipophilicity, insolubility and adverse side effects, nanocarriers were...
Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc up-regulated in NPC and its expression associated with poor prognosis.We hypothesized that constitutes an important hyperthermia target, we investigated contribution to responses NPC.The growth of the human cell lines CNE1 CNE2 was analyzed using CCK-8 clonogenicity assays after 43 °C hyperthermia, knockdown or overexpression c-Myc. Flow cytometry...
Background Bone is the most common metastatic site of Breast invasive carcinoma (BRCA). In this study, bone metastasis-specific regulation network BRCA was constructed based on prognostic stemness-related signatures (PSRSs), their upstream transcription factors (TFs) and downstream pathways. Methods Clinical information RNA-seq data 1,080 primary samples (1,048 without metastasis 32 with metastasis) were downloaded from The Cancer Genome Atlas (TCGA). edgeR method performed to identify...
Objective To investigate the influence of enteral nutrition on body weight, nutritional status, treatment toxicities, and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy (CCRT). Methods Eligible were randomly assigned (2: 1) to receive either CCRT combined (study group) or alone (control group). The primary endpoint was changes weight during after radiotherapy. secondary endpoints nutrition-related hematological parameters, toxicities...