A5040873593- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- RNA modifications and cancer
- Healthcare professionals’ stress and burnout
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Rheumatoid Arthritis Research and Therapies
- Cancer Cells and Metastasis
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer Mechanisms and Therapy
- Innovations in Medical Education
- Empathy and Medical Education
- Sarcoma Diagnosis and Treatment
- Pressure Ulcer Prevention and Management
- Osteoarthritis Treatment and Mechanisms
- Perfectionism, Procrastination, Anxiety Studies
- Circular RNAs in diseases
- Immune cells in cancer
- Mesenchymal stem cell research
- Educational Environments and Student Outcomes
- Systemic Lupus Erythematosus Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Second Military Medical University
2024-2025
Tongji University
2019-2024
Academy of Medical Sciences
2024
Academia Sinica
2024
Shanghai Zhabei District Shibei Hospital
2023
First Affiliated Hospital of Zhengzhou University
2023
Shanghai Tenth People's Hospital
2019-2022
Shanghai First People's Hospital
2022
Tongji Hospital
2021
(1) Background: Non-small cell lung cancer (NSCLC) is the most common cancer. Enhancer RNA (eRNA) has potential utility in diagnosis, prognosis and treatment of cancer, but role eRNAs NSCLC metastasis not clear; (2) Methods: Differentially expressed transcription factors (DETFs), enhancer RNAs (DEEs), target genes (DETGs) between primary metastatic were identified. Prognostic DEEs (PDEEs) screened by Cox regression analyses a predicting model for was constructed. We identified DEE...
Empathy of medical students is crucial, yet it tends to decline as enter later academic years. appeared be affected by the learning environment (LE), which could a potential contributor. We conducted cross-sectional study investigate association between LE and empathy. The comprised overall 10,901 from 12 Chinese schools. Jefferson Scale (JSE) was utilized assess empathy, while 5-point question Johns Hopkins Learning Environment were employed evaluate LE. JSE scores compared across levels...
Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions TSPANs and their roles in pan-cancer unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, TSPAN32, TSPAN33, TSPAN4, TSPAN5, TSPAN6, TSPAN7, TSPAN8, TSPAN9, TSPAN9-IT1 (24 TSPAN family genes) relation to tumor characteristics from 11,057 TCGA samples across 33 cancer types. On 24...
Background Rheumatoid Diseases (RDs) are a group of systemic auto-immune diseases that characterized by chronic synovitis, and fibroblast-like synoviocytes (FLSs) play an important role in the occurrence progression synovitis. Our study is first to adopt bibliometric analysis identify global scientific production visualize its current distribution 21st century, providing insights for future research through themes keywords. Methods We obtained publications from core collection Web Science...
Burns lead to systemic changes manifested by disturbances in water-electrolyte balance and metabolic inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, dysregulation mechanisms. This study aimed provide comprehensive bibliometric analysis of the metabolism research field, identifying key trends, influential contributors, emerging hotspots inform future investigative efforts. Ultimately, we conducted an extensive review literature,...
Objective: We aim to determine the optimal timing and approaches for first tangential excision of severely burned patients ≥70% total body surface area (TBSA). Background: Early is gold-standard surgical therapy full-thickness burns. However, there are debates about its ≥70%TBSA. Materials Methods: This study included 185 in Kunshan factory explosion. focused on timing, area, main wound covering method excision. determined cut-off values using R language “surv_cutpoint” “surv_categorize”...
Medical school learning environment (MSLE) is highly related to medical students' academic performance. However, the grade point average (GPA) rankings have not been studied together with MSLE. We aim figure out relationship between GPA and gathered data from 12 schools in mainland China, employing Johns Hopkins Learning Environment Scale (JHLES) assess subjective perceptions of Subsequently, we performed a cross-sectional study examining JHLES scores. conducted Pearson's Chi-square test...
Rheumatic diseases (RD) are a group of multi-system inflammatory autoimmune whose causes still under study. In the past few decades, researchers have found traces association between rheumatic and intestinal microbiota, which can partially explain pathogenesis diseases. We aimed to describe research trend main divisions on how gut flora interreacts with diseases, discussed about possible clinical applications.We analyzed bibliometric data from Web Science core collection (dated 15th May...
Background Diabetic foot ulcers (DFUs) are one of the most popular and severe complications diabetes. The persistent non-healing DFUs may eventually contribute to such as amputation, which presents patients with significant physical psychological challenges. Fibroblasts critical cells in wound healing perform essential roles all phases healing. In diabetic patients, disruption fibroblast function exacerbates wound. This study aimed summarize hotspots evaluate global research trends on...
Abstract Background Fostering empathy has been continuously emphasized in the global medical education. Empathy is crucial to enhance patient-physician relationships, and associated with students’ academic clinical performance. However, level of students China related influencing factors are not clear. Methods This was a cross-sectional study among 11 universities. We used Jefferson Scale Student-version Chinese version measure students. Factors were identified by univariate multivariate...
Introduction Over the last several decades, gut microbiota has been implicated in formation and stabilization of health, as well development disease. With basic clinical experiments, scholars are gradually understanding important role trauma, which may offer novel ideas treatment for trauma patients. In this study, we purposed to summarize current state access future trends research. Methods We retrieved relevant documents their published information from Web Science Core Collection (WoSCC)....
Malignant mesothelioma is a type of infrequent tumor that substantially related to asbestos exposure and has terrible prognosis. We tried produce fibroblast differentiation-related gene set for creating novel classification prognostic prediction model MESO. Three databases, including NCBI-GEO, TCGA, MET-500, separately provide single-cell RNA sequencing data, bulk profiles MESO, information on bone metastatic tumors. Dimensionality reduction clustering analysis were leveraged acquire...
Background Study engagement is regarded important to medical students’ physical and mental wellbeing. However, the relationship between learning environment of schools study students was still unclear. This aimed ascertain positive effect in engagement. Methods We collected 10,901 valid questionnaires from 12 universities China, UWES-S utilized assess levels. Then Pearson Chi-Square test Welch’s ANOVA were conducted find environment, subgroup analysis used eradicate possible influence...
Abstract Background Medical school learning environment (MSLE) has a holistic impact on students’ psychosomatic health, academic achievements, and personal development. Students in different grades perceive MSLE ways. Thus, it is essential to investigate the specific role of student’s grade perception MSLE. Methods Using Johns Hopkins Learning Environment Scale (JHLES) as quantification instrument for level MSLE, 10,901 medical students 12 universities China were categorized into low or high...
Medical students' perceptions of the medical school learning environment (MSLE) have an important impact on their professional development, and physical mental health. Few studies reported potential factors that influenced MSLE. Thus, main goal this study was to identify influencing for perception levels The MSLE were assessed by Johns Hopkins Learning Environment Scale. univariate multivariate logistic regression analyses performed significant predictors nomograms established predict In...
Osteoarthritis (OA) is a chronic disease with high economic burden characterized by cartilage degradation and joint inflammation. Evodiamine (EV), which can be extracted from Evodia rutaecarpa (Rutaceae), traditional Chinese medicine to treat inflammation, cardiovascular disorders, infection, obesity. Studies have shown that EV suppress the activation of immune cells restrain secretion pro-inflammatory cytokines. However, it still not well known about its role in treatment OA. In this study,...
Toll-like receptors (TLRs) are important components of the innate and adaptive immune systems, abnormal TLR expression has been linked to a variety cancers. However, there was lack clarity on association stimulation with carcinogenesis cancer. The study's goal analyse clinical importance TLRs at mRNA level in pan-cancer datasets, as well link between carcinogenesis, progression, prognosis.The profile derived from UCSC data analysed multiple dimensions, including analysis, immunological...
Background Rheumatism covers a wide range of diseases with complex clinical manifestations and places tremendous burden on humans. For many years, our understanding rheumatism was seriously hindered by technology constraints. However, the increasing application rapid advancement sequencing in past decades have enabled us to study greater accuracy more depth. Sequencing has made huge contributions field is now an indispensable component powerful tool rheumatism. Methods Articles rheumatism,...
BACKGROUND:Osteosarcoma is one of the most common bone tumors, with strong local aggressiveness and early metastasis. The aim this study was to describe epidemiological data evaluate prognostic factors for overall survival (OS) cause-specific (CSS) in patients non-metastatic osteosarcoma. MATERIAL AND METHODS:Patients histologically diagnosed osteosarcoma between 2005 2014 were selected from Surveillance, Epidemiology, End Results (SEER) database. Survival analysis, machine learning, Lasso...
Bladder cancer (BLCA), originating from the epithelium of urinary bladder, was second most common malignancy in system with a high metastasis rate and poor post-metastasis prognosis. Alternative splicing events (ASEs) were regarded as important markers tumor progression prognosis, however, their roles bladder bone have not been recognized. In this study, we constructed predictive model based on ASEs explored molecular mechanism BLCA metastasis, data Cancer Genome Atlas (TCGA) TCGASpliceSeq...
Invasion and metastasis of cervical cancer are the main factors affecting prognosis patients with squamous cell carcinoma (CESC). Therefore, it is vital importance to find novel biomarkers that associated CESC invasion metastasis, which will aid in amelioration individualized therapeutic methods for advanced patients.The gene expression profiles 10 metastatic 116 non-metastatic samples were downloaded from The Cancer Genome Atlas (TCGA), where differentially expressed genes (DEGs) defined....
Studies exploring influencing factors of emotional engagement among medical students are scarce. Thus, we aimed to identify students' engagement.We carried out a multi-center cross-sectional study 10,901 from 11 universities in China. The Chinese version Utrecht Work Engagement Scale-Student (UWES-S) was used evaluate level students. predictors related were determined by the logistic regression analysis. Furthermore, constructed nomogram predict students.A total 10,576 sample included this...