A5072316136- Diabetes and associated disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Gout, Hyperuricemia, Uric Acid
- Pancreatic function and diabetes
- Systemic Lupus Erythematosus Research
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Radiation Therapy and Dosimetry
- Atomic and Molecular Physics
- Mass Spectrometry Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Ginseng Biological Effects and Applications
- Mobile Health and mHealth Applications
- Ferroptosis and cancer prognosis
- Plant-based Medicinal Research
- Digital Mental Health Interventions
- Erythrocyte Function and Pathophysiology
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
- Immune responses and vaccinations
- Transgenic Plants and Applications
- Case Reports on Hematomas
- Traditional Chinese Medicine Analysis
Changchun Institute of Biological Products
2025
Air Force Medical University
2024
Fudan University
2023-2024
Huashan Hospital
2023-2024
Shanghai Jiao Tong University
2021-2023
Lanzhou University
2008
First Hospital of Lanzhou University
2008
Peking University
2006
Augusta University
2006
Chinese Academy of Medical Sciences & Peking Union Medical College
2005
Abstract Insulin-dependent diabetes mellitus is an autoimmune disease that characterized by the destruction of insulin-producing beta cells in islet Langerhans. We have recently reported induction nonobese diabetic (NOD) mice can be prevented a single injection CFA. In this study, we explored cellular basis and time course protection. Since CFA contains mycobacterial cell wall has adjuvant property, investigated protective role mycobacteria young NOD mice. Mice injected with Mycobacterium...
The role of IL-4 in the cellular interactions leading to induction CTL tolerance H-2b alloantigens and development a lupus-like autoimmune disease BALB/c mice after neonatal injection with (C57BL/6 x BALB/c)F1 cells was investigated vivo by using an anti-IL-4 mAb. Treatment F1 cell-injected 15 mg mAb shown interfere induction, as assessed high percentages target cell lysis very low or undetectable levels B chimerism markers observed these mice. 4.5 interfered only one-third mice, but that...
Optimal T cell responsiveness requires signaling through the receptor (TCR) and CD28 costimulatory receptors. Previously, we showed that cells from autoimmune nonobese diabetic (NOD) mice display proliferative hyporesponsiveness to TCR stimulation, which may be causal development of insulin-dependent diabetes mellitus (IDDM). Here, demonstrate anti-CD28 mAb stimulation restores complete NOD by augmentation IL-4 production. Whereas neonatal treatment with beginning at 2 wk age inhibits...
Immunization with mycobacterial preparation such as Bacille Calmette–Guérin (BCG) or complete Freund's adjuvant (CFA) prevents the onset and recurrence of type 1 diabetes in non-obese diabetic (NOD) mice. In this study, we explored mechanism underlying down-regulation diabetogenic T cells by BCG treatment. We found that potential splenocytes from BCG-immunized NOD mice to adoptively transfer was significantly impaired. immunization sequentially induced production TNF-α, IFN-γ IL-4...
Background: COVID-19, caused by SARS-CoV-2, poses a significant threat to human health. Vaccines designed for T-cell epitopes play an important role in eliminating the virus. However, T cell epitope screening often requires use of large number peripheral blood mononuclear cells (PBMCs) from infected or convalescent patients, and if MHC humanized mice can be used screening, they will not have wait enough PBMCs available screen epitopes, thus buying time confirmation vaccine design. Methods:...
The aim of this article was to review existing documents in the field mobile-based EMA and EMI, provide an overview current hot topics, predict future development trends. We conducted a bibliometric study on EMI publications that were collected from Web Science Core Collection database. Biblioshiny CiteSpace utilized analyze scientific productions, leading sources, authors, affiliations, documents, research keywords, trend topics. A total 2222 related published between 1992 2023 retrieved....
Abstract The occurrence of metastasis is a serious risk for renal cell carcinoma (RCC) patients. In order to develop novel therapeutic approaches control the progression metastatic RCC, it urgent need understand molecular mechanisms underlying RCC and identify prognostic markers risk. Matrix metalloproteinases (MMPs) tissue inhibitors (TIMPs) have been known be closely associated with extracellular matrix (ECM) turnover, which plays highly active role in tumor metastasis. Recent studies...
Background Rheumatism covers a wide range of diseases with complex clinical manifestations and places tremendous burden on humans. For many years, our understanding rheumatism was seriously hindered by technology constraints. However, the increasing application rapid advancement sequencing in past decades have enabled us to study greater accuracy more depth. Sequencing has made huge contributions field is now an indispensable component powerful tool rheumatism. Methods Articles rheumatism,...
Background Spinal cord injury (SCI) is a severe disease with motor and sensory function being destroyed, which leads to poor prognosis serious financial burden. It urgent figure out the molecular pathological mechanisms of SCI develop feasible therapeutic strategies. This article aims review documents focused on gene expression in summarize research hotspots development process this field. Methods Publications SCI-related studies from 2000 2022 were retrieved Web Science Core Collection...
Chemotherapy resistance in liver cancer is a major clinical issue, with CD147 playing vital role this process. However, the specific mechanisms underlying these processes remain largely unknown. This study investigates how internalization leads to cytoprotective autophagy, contributing chemotherapy hepatocellular carcinoma (HCC). Utilizing bioinformatics methods for KEGG pathways enrichment and screening key molecules associated through analyses of GEO TCGA databases. An...
BALB/c mice neonatally injected with 108 semiallogenic (C57BL/6×BALB/c)FI spleen cells become tolerant to the H-2b alloantigens, but also develop a wide range of autoimmune manifestations characteristic systemic lupus erythematosus (SLE). Indeed, in these mice, presence hypergammaglobulinaemia, auto-antibodies - including anti-ssDNA, anti-platelet, thymocytotoxic and rheumatoid factor antibodies circulating immune complexes, cryoglobulins as well renal glomerular deposition immunoglobulins...
This paper describes a rapid and sensitive high-performance liquid chromatographic (HPLC) method for the determination of concentration tanshinone I in rat plasma, applies to pharmacokinetic study. The plasma is deproteinized with acetonitrile containing an internal standard (estradiolbenzoate). HPLC assay carried out using Cosmosil C18 column. mobile phase acetonitrile, 0.05 mol/L(-1) ammonium acetate buffer 1% acetic acid (66:34, v/v). flow rate 1.0 mL/min. detection wavelength set at 263...
Background: The signal transducer and activator of transcription (STAT) gene family have been widely found to regulate cell proliferation, differentiation, apoptosis, angiogenesis through complex signaling pathways, thus impacting tumor formation development in different types tumor. However, the roles STATs on prognostic prediction therapeutic guidance pan-cancer remain unexplored. Materials Methods: dataset 33 TCGA tumor, para-carcinoma normal tissues, was obtained from UCSC Xena database,...