A5062270073- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Shoulder Injury and Treatment
- Transgenic Plants and Applications
- Cell death mechanisms and regulation
- Liver Diseases and Immunity
- Urological Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Sports injuries and prevention
- 3D Printing in Biomedical Research
- Biomedical Research and Pathophysiology
- Phagocytosis and Immune Regulation
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Clinical Nutrition and Gastroenterology
- Renin-Angiotensin System Studies
- Hemoglobinopathies and Related Disorders
- Metabolism and Genetic Disorders
- Organ Donation and Transplantation
- Nitric Oxide and Endothelin Effects
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Diabetic Foot Ulcer Assessment and Management
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
London Health Sciences Centre
2006-2014
Lawson Health Research Institute
2014
Western University
1997-2010
Robarts Clinical Trials
1996-2003
Cell death results in tissue damage and ultimately donor graft rejection can occur as an active molecular process through apoptotic, necrotic newly identified receptor interacting protein 1 3 kinase (RIPK1/3)-mediated necroptotic pathways. Necroptosis leads to the release of inflammatory molecules which activate host immune cells. This pathway has yet be studied heart transplantation. We have found that necroptosis was induced murine cardiac microvascular endothelial cell (MVEC) under...
ABSTRACT Diabetic nephropathy (DN) is a major complication of diabetes that can advance to end‐stage renal disease, posing substantial health risk. The Qianshi Mixture (QSM) has shown therapeutic potential for DN; however, its pharmacological mechanisms remain insufficiently understood. We developed DN model in mice and administered QSM as an intervention. To assess QSM's effects, we measured the renal‐function‐related biochemical indicators examined kidney pathological changes. then applied...
Renal NOS2 is expressed and produces abundant nitric oxide (NO) in various renal cells response to proinflammatory cytokines. However, the role of this enzyme allograft survival remains unknown. Kidney allotransplantation was performed murine model C57BL/6J (H-2(d)) nephrectomized Balb/c (H-2(b)) mice. Here we show that deficiency expression kidney donors significantly advanced failure, indicated by decreasing mean recipients receiving null grafts (15.4 +/- 6.4 days) as compared those with...
MRL/Mp-lpr/lpr (MRL-lpr) mice develop an aggressive autoimmune disorder characterized by arthritis, vasculitis, and glomerulonephritis. Renal injury is associated with increased expression of major histocompatibility complex (MHC) molecules, as well cytokines, adhesion molecules (intracellular molecule-1, vascular cell molecule-1), autoantibodies. By using either MHC Class I (MRL-lpr B2m-/-) or II deficient Ab-/-) kidneys in a transplant model, we tested the role renal these development...
Introduction The healing of rotator cuff injuries poses significant challenges, primarily due to the complexity recreating native tendon-to-bone interface, characterized by highly organized structural and compositional gradients. Addressing this, our innovative approach leverages bioprinted living tissue constructs, incorporating layer-specific growth factors (GFs) facilitate enthesis regeneration. This method aims guide in situ zonal differentiation stem cells, closely mirroring natural...
Abstract Rotator cuff injuries often result in chronic pain and functional limitations due to retears scar formation at the enthesis. This study assess efficacy of electrohydrodynamic‐printed microfibrous dual‐triphase scaffolds (DTSs), designed optimize enthesis repair. These scaffolds, composed polycaprolactone enhanced with nanohydroxyapatite, nano‐magnesium‐oxide, kartogenin demonstrate significant biological advantages. In vitro, support over 95% stem cell viability promote expression...
Epigallocatechin-3-O-gallate is natural phytochemical of green tea. RAGE upregulation promotes osteoarthritis (OA) progression. Herein, we revealed that EGCG can repress expression epigenetically to ameliorate OA. Firstly found was dose-dependently reduced by on chondrocyte cell C28/I2. also suppressed in human primary OA chondrocytes, and accordingly attenuated ROS production NF-κb activity. Osteoarthritic microenvironment improved EGCG, which reflected the enhanced chondrogenic markers...
Introduction: Proteinase inhibitor 9 (PI-9) is an intracellular serpin that inhibits Granzyme B (GrB), a serine protease found in the cytosolic granules of CD8+ T and Natural Killer (NK) cells. PI-9 functions to prevent “misdirected” apoptosis GrB expressing The murine homolog 6 (SPI-6). Kidney tubular epithelial cells (TEC) are principal targets for cytotoxic following transplant. Therefore TEC resistance cell mediated injury may influence graft survival function. expression regulation...
Chronic allograft injury remains the leading cause of late kidney graft loss despite improvements in immunosuppressive drugs and a reduction acute T cell mediated rejection. We have recently demonstrated that NK cells are cytotoxic to tubular epithelial (TECs) contribute ischemia-reperfusion (IRI). The role rejection has not been studied. A parent F1 transplant model which tolerance is present, was utilized for these studies. C57BL/6 kidneys were transplanted into fully nephrectomized...
Zhang, Z.1; Jiang, J.2; Huang, X.3; Yin, Z.3; Liu, W.4; Garcia, B.4; Jevnikar, A. M.2 Author Information
Shek, K.; Zhang, Z.; Khan, Wang, S.; Lau, A.; Yin, Liu, W.; Garcia, B.; Singh, H.; Jevnikar, A. M. Author Information