A5101796651- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Quinazolinone synthesis and applications
- Insect and Pesticide Research
- Renal and related cancers
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Insect and Arachnid Ecology and Behavior
- RNA Interference and Gene Delivery
- Insect Utilization and Effects
- Cell death mechanisms and regulation
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Reproductive Biology and Fertility
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
- Extracellular vesicles in disease
- Circular RNAs in diseases
University of Kansas
2016-2025
Fuyang Normal University
2016-2025
Fujian Medical University
2025
Fuzhou Maternity and Child Health Care Hospital
2025
Shenzhen University
2020-2025
Ningbo University
2025
The University of Kansas Cancer Center
2021-2024
University of Kansas Medical Center
2022-2024
Zhanjiang Experimental Station
2024
Zhejiang University
2023-2024
Antiapoptotic members of the Bcl-2 family proteins are overexpressed in prostate cancer and promising molecular targets for modulating chemoresistance cancer. (-)-Gossypol, a natural BH3 mimetic, is small-molecule inhibitor Bcl-2/Bcl-xL/Mcl-1 currently phase II clinical trials as an adjuvant therapy human Our objective to examine chemosensitization potential (-)-gossypol its mechanisms action. (-)-Gossypol inhibited cell growth induced apoptosis through mitochondria pathway PC-3 cells...
HuR, an RNA binding protein, binds to adenine- and uridine-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs, regulating their stability translation. HuR is highly abundant many types cancer, it promotes tumorigenesis by interacting with cancer-associated which encode proteins that are implicated different tumor processes including cell proliferation, survival, angiogenesis, invasion, metastasis. Drugs disrupt stabilizing effect upon mRNA targets could have dramatic...
An inkjet-printed nanochip integrating multiparametric extracellular vesicle analyses monitors tumor burden via liquid biopsy.
Musashi‐1 (MSI1) is an RNA‐binding protein that acts as a translation activator or repressor of target mRNAs. The best‐characterized MSI1 Numb mRNA, whose encoded negatively regulates Notch signaling. Additional targets include the mRNAs for tumor suppressor APC Wnt signaling and cyclin‐dependent kinase inhibitor P21WAF−1. We hypothesized increased expression NUMB, P21 APC, through inhibition activity might be effective way to simultaneously downregulate signaling, thus blocking growth broad...
Abstract Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in cancer, and elevated cytoplasmic HuR correlates high-grade tumors poor clinical outcome cancer. promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, cytokines that support major tumor hallmarks including invasion metastasis. Here, we report inhibitor KH-3, which potently suppresses cell invasion....
Abstract Background As a novel class of non-coding RNAs, circular RNAs (circRNAs) are key regulators the development and progression different cancers. However, little is known about function biological mechanism circLMTK2, also named hsa_circ_0001725, in gastric cancer (GC) tumourigenesis. Methods circLMTK2 was identified ten paired specimens adjacent normal tissues by RNA sequencing genome-wide bioinformatic analysis verified quantitative real-time PCR (qRT-PCR). Knockdown or exogenous...
Chemo/radio-therapy resistance to the deadly pancreatic cancer is mainly due failure kill stem cells (CSCs). Signal transducer and activator of transcription 3 (STAT3) activated in CSCs and, therefore, may be a valid target for overcoming therapeutic resistance. Here we investigated potential STAT3 inhibition sensitizing chemo/radio-therapy. We found that levels nuclear pSTAT3 correlated with advanced tumor grade poor patient outcome. Liposomal delivery inhibitor FLLL32 (Lip-FLLL32)...
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in initiation progression pancreatic cancer. However, therapeutically targeting STAT3 has failed clinically. We previously identified HAb18G/CD147 as an effective target for cancer treatment. In this study, we aimed to investigate the potential STAT3-involved tumorigenesis vitro vivo.The expression HAb18G/CD147, pSTAT3, CD44s was determined tissue microarrays. The tumorigenic function molecular signaling...
Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which thought to contribute this tumor's malignant behavior. Epithelial-mesenchymal transition (EMT) regarded as a crucial contributing factor progression. Galectin-1 (Gal-1), β-galactoside-binding protein abundantly expressed in activated cancer-associated fibroblasts (CAFs), has been reported be involved GC progression and metastasis binding β1 integrin, which, turn, can bind matrix proteins activate...
RNA binding proteins represent an emerging class of with a role in cardiac dysfunction. We show that activation the protein human antigen R (HuR) is increased failing heart. To determine functional HuR pathological hypertrophy, we created inducible cardiomyocyte-specific HuR-deletion mouse and showed deletion reduces left ventricular dilation, fibrosis while preserving function transverse aortic constriction (TAC) model pressure overload–induced hypertrophy. Assessment HuR-dependent changes...
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles tumorigenesis. Thus, small molecules interfere with interaction could potentially inhibit cancer cell growth and progression. Using a fluorescence polarization (FP) competition assay, we identified compound azaphilone-9 (AZA-9) derived from fungal natural product asperbenzaldehyde, HuR...
Abstract Colorectal cancer (CRC) is the third most common malignant tumor worldwide and a serious threat to human health. MicroRNAs (miRNAs) play key role in oncogenesis progression. MiRNA-125 (miR-125) an important miRNA that dysregulated several kinds of cancers. Thus, we investigated expression effects miR-125 Transcriptional co-activator with PDZ-binding motif (TAZ) for better understanding underlying mechanism progression CRC, which may provide emerging biomarker diagnosis treatment...
Abstract Pancreatic cancer has poor prognosis and treatment outcomes due to its highly metastatic nature resistance current treatments. The RNA-binding protein (RBP) Hu-antigen R (HuR) is a central player in posttranscriptional regulation of cancer-related gene expression, contributes tumorigenesis, tumor growth, metastasis, drug resistance. HuR been suggested regulate pancreatic epithelial-to-mesenchymal transition (EMT), but the mechanism was not well understood. Here, we further...
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in several types of diseases, including cancer, making it promising therapeutic target. We have identified small-molecule inhibitors HuR through screening approach used combination with fragment analysis. A total 36 new compounds originating from linking or structural optimization were studied to establish structure–activity relationships the set. Two top inhibitors, 1c and 7c, further validated by...
Hypoxia is a severe stress which induces physiological and molecular adaptations, where the latter dominated by Hypoxia-inducible transcription Factor (HIF). A well described response on cellular level upon exposure to hypoxia reversible cell cycle arrest, probably renders cells more resistant difficult environment. The individual roles of itself isoforms HIF-1α HIF-2α in regulation are poorly understood discussed controversially. In order characterize isolated effect both HIFα we generated...
Background: Gastric cancer is one of the most commonly diagnosed cancers each year, and it remains third leading cause death in world. The clinicopathologic characteristics differ among regions, so epigenetic changes play a key role gastric carcinogenesis. Methods: In present study, we first demonstrate that cardamonin, natural production chalcone, an anti-gastric agent pre-clinical evaluation. Results: Cardamonin inhibited proliferation migration, induced apoptosis cells. It could reduce...
The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation target mRNAs. Elevated MSI1 levels a variety human cancer are associated with up-regulation Notch/Wnt signaling. binds to and negatively regulates translation Numb APC (adenomatous polyposis coli), negative regulators Notch Wnt signaling respectively. Previously, we have shown that natural product (−)-gossypol as first small molecule inhibitor down-regulates inhibits tumor xenograft...
Abstract Ginsenoside Rg3, a ginsenoside isolated from Panax ginseng , can regulate autophagy via AMP‐activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signaling pathway. AMPK/mTOR and have been reported to be involved in osteogenesis. Here, the effect Rg3 on ovariectomy (OVX)‐induced osteoporosis is explored. In vivo, rats were treated with 20 mg/kg after OVX body weight (BW) was monitored. Bone mineral density (BMD), hematoxylin–eosin staining femur tissues, osteogenesis,...