A5042287156- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Wheat and Barley Genetics and Pathology
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Genetic Mapping and Diversity in Plants and Animals
- Hedgehog Signaling Pathway Studies
- Transplantation: Methods and Outcomes
- Bladder and Urothelial Cancer Treatments
- T-cell and B-cell Immunology
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Trypanosoma species research and implications
- Ferroptosis and cancer prognosis
- Genetics and Neurodevelopmental Disorders
- Urinary and Genital Oncology Studies
- Wnt/β-catenin signaling in development and cancer
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
Union Hospital
2025
Huazhong University of Science and Technology
2025
University of Kansas
2020-2024
Nanjing Medical University
2010-2024
Hainan Medical College Hospital
2023-2024
Wuxi People's Hospital
2010-2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Hebei General Hospital
2021
Harbin Medical University
2017-2020
Second Affiliated Hospital of Harbin Medical University
2017-2020
Introduction Colorectal cancer (CRC) represents the third most prevalent form of worldwide, with liver metastasis representing a significant contributor to mortality. The interaction between tumor-associated macrophages (TAMs) and tumor cells plays pivotal role in development colorectal metastases (CRLM) promising avenue for therapeutic intervention. Stachydrine (STA), compound derived from Leonurus heterophyllus plant, has been shown effectively inhibit growth through range mechanisms....
Gastric carcinoma (GC) is a common and lethal malignancy, epithelial-mesenchymal transition (EMT) believed to contribute invasive metastatic tumor growth. Aquaporin 3 (AQP3) overexpressed in human GC tissues, while epidermal growth factor (EGF) hepatocyte factor, which can induce EMT, are able up-regulate AQP3 expression, subsequently promoting cell migration proliferation. The purpose of this study was investigate the effects on EMT GC. EMT-related proteins were detected by...
Abstract Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in cancer, and elevated cytoplasmic HuR correlates high-grade tumors poor clinical outcome cancer. promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, cytokines that support major tumor hallmarks including invasion metastasis. Here, we report inhibitor KH-3, which potently suppresses cell invasion....
Abstract Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N 6 -methyladenosine (m A) regulate BC tumorigenesis are still unclear. In present research, LINC00958 was markedly overexpressed tissue cells, upregulation promoted tumor progression of cells. Mechanistically, m A methyltransferase-like 3 (METTL3) gave rise to promoting its RNA transcript stability. Moreover,...
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in several types of diseases, including cancer, making it promising therapeutic target. We have identified small-molecule inhibitors HuR through screening approach used combination with fragment analysis. A total 36 new compounds originating from linking or structural optimization were studied to establish structure–activity relationships the set. Two top inhibitors, 1c and 7c, further validated by...
Background: MIAT (myocardial infarction-associated transcript) regulates cell proliferation, apoptosis, and metastasis in several cancers. In this study, the authors aimed to explore role of ovarian cancer. Materials Methods: The expression cancer subtypes, normal human surface epithelial lines was measured by qualitative real-time polymerase chain reaction (qRT-PCR). OVCAR3 SKOV3 cells were transfected with overexpression plasmid or siMIAT. growth ability then evaluated CCK-8 colony...
Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing C14α-methyl group lanosterol, key step in ergosterol biosynthesis Leishmania. However, they exhibit varying degrees activities culture, suggesting existence unrecognized molecular targets. Our previous study reveals that, Leishmania, lanosterol undergoes parallel...
Glioblastoma is the most malignant type of brain tumor, and its high invasiveness multiplication severely shortens patients' overall survival. The embryonic pyruvate kinase M2 (PKM2) isoform highly expressed in human cancer. We used computational target gene prediction, vitro cell culture, immunoblotting, quantitative real-time PCR, ATP measurements, luciferase reporter assays, wound-healing Transwell RNA immunoprecipitation co-immunoprecipitation, flow cytometry tumor xenografts to study...
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability caused by a CGG repeat expansion in 5' untranslated region FMR1 gene. When number repeats exceeds 200, gene becomes hypermethylated and transcriptionally silenced, resulting FXS. Other allelic forms that are studied because their instability or phenotypic consequence include intermediate alleles (45-54 repeats) premutation (55-200 repeats). Normal classified as having <45 repeats. Population screening...
Breast cancer is the most common female malignancy and major cause of cancer-related death in women. Long non-coding RNAs (lncRNAs), as oncogenic or tumor suppressor factor, involved development progression various cancers. In this study, we sought to investigate function lncRNA CBR3-AS1 breast cancer. We evaluated expression pattern tissues cell lines, explored correlation between survival time patients, probed effect on through loss-of-function gain-of-function strategies. Our results...
Southern corn rust (SCR) caused by Puccinia polysora Underw is a major disease leading to severe yield losses in China Summer Corn Belt. Using six multi-locus GWAS methods, we identified set of SCR resistance QTNs from diversity panel 140 inbred lines collected Thirteen on chromosomes 1, 2, 4, 5, 6, and 8 were grouped into three types allele effects their associations with phenotypes verified post-GWAS case-control sampling, allele/haplotype effect analysis. Relative (RRR) relative...
Breast cancer metastasis to the stomach is relatively rare. Unlike infiltrating ductal carcinoma, invasive lobular carcinoma (ILC) has a high tendency metastasize stomach. The present study reports case of 53-year-old female who had undergone modified radical mastectomy left breast for ILC eight years previously and presented at clinic seeking treatment epigastric discomfort from sour regurgitation belching that persisted one month. Gastroscopy revealed multiple apophysis lesions in stomach,...
Tumor suppressor gene silencing via promoter hypermethylation is an important event in pancreatic cancer pathogenesis. Aberrant DNA events are highly tumor specific, and may provide a diagnostic tool for patients. The objective of the current study was to identify novel methylation-related genes that potentially be used establish therapeutic strategies against cancer. methylation status GS homeobox 2 (GSH2) analyzed using sodium bisulfite sequencing method. GSH2 ratio examined primary...
The Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), which is used as a marker of adult stem cells and colorectal cancer (CSCs), closely associated with the progression non-small cell lung (NSCLC). This study aimed to identify clinical significance biological function LGR5 in NSCLC.Quantitative reverse transcription polymerase chain reaction (RT-PCR) was applied detect expression stemness-related genes 22 NSCLC patients, estimated by statistical analysis. overexpressing...
BACKGROUND: Cervical cancer (CC) is a common female malignancy, with global incidence rate second only to breast cancer. OBJECTIVE: To propose new idea for early treatment and auxiliary diagnosis of CC by exploring the diagnostic prognostic implications serum miR-182 in CC. METHODS: We enrolled 70 patients, 35 cervical intraepithelial neoplasia (CIN) patients healthy controls (HCs), who visited The First Affiliated Hospital Hainan Medical College between January 2015 April 2016. expression...
：Interleukin-2-inducibleT-cell kinase(Itk)is a member of the Tec family non-receptor tyrosine kinases.As keycomponent T-ceil-receptor signaling,Itk contribute lot in T cells development anddifferentation,especially function Th2(T-helper 2)cells.Recent data shows thatItk is important some inflammation and immune-Mediated disorders,such as allergicasthma,atopic dermatitis,HIV Parasitic infections.To understand molecularbiological characteristics Itk its role immune regulation...
Objective To investigate the value of leucine-rich repeat-containing G protein coupled receptor 5 (LGR5) and aldehyde dehydrogenase 1A1 (ALDH1A1) in progression prognosis non-small-cell lung cancer (NSCLC), order to find new targets for NSCLC-targeted imaging radiation therapy. Methods Fresh tissues (n=24) paraffin embedding (n=109) patients with NSCLC were collected from First Affiliated Hospital Soochow University between November 2009 March 2012. Quantitative real time-PCR was used...