A5035930336- Diabetes Treatment and Management
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- RNA modifications and cancer
- Spinal Dysraphism and Malformations
- Occupational and environmental lung diseases
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Sperm and Testicular Function
- Pleural and Pulmonary Diseases
- Glaucoma and retinal disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Retinal and Macular Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Uterine Myomas and Treatments
- Ovarian function and disorders
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
Yunnan University
2024-2025
Yanbian University
2019-2024
Yanbian University Hospital
2019-2024
Weatherford College
2022-2023
Abstract Objective Previous experiments have demonstrated that BGM0504, a GLP‐1R/GIPR dual agonist drug by molecular dynamics‐guided optimization, had enhanced agonistic activity compared to tirzepatide. This study aims investigate its safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) in Chinese healthy volunteers. Methods A randomized, double‐blind, placebo‐controlled dose‐escalation Phase I was conducted as follows: single dose (2.5 mg) once‐weekly administration for 2...
ABSTRACT Diabetic nephropathy (DN) is a major complication of diabetes that can advance to end‐stage renal disease, posing substantial health risk. The Qianshi Mixture (QSM) has shown therapeutic potential for DN; however, its pharmacological mechanisms remain insufficiently understood. We developed DN model in mice and administered QSM as an intervention. To assess QSM's effects, we measured the renal‐function‐related biochemical indicators examined kidney pathological changes. then applied...
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is a common malignant gynecological cancer. The ceRNA networks play important roles in many tumors, while RILPL2-related network has been seldom studied CESC. All CESC data was obtained from TCGA database. Differentially expressed RNAs predicted target were cross analyzed to construct network. RNA clinicopathological characteristics' influence on overall survival (OS) determined by univariate multivariate Cox regression...
Objective: To explore the effect of acupuncture at Fuguan point combined with tamoxifen citrate tablet on sperm motility parameters. Methods: A total 115 individuals asthenospermia were categorized based different treatment regimens: 53 patients in control group (receiving tablets) and 62 observation (undergoing acupoint conjunction tablets). Both groups underwent a 3-month period. The computer-assisted analysis system was employed to measure various parameters human sperm, including rate,...
E3 ligases are engaged in a variety of physiological processes within cells and use ubiquitin-labeled substrates to control their activity stability. Although some research has indicated that or particular have an impact on the treatment cervical cancer patients get after diagnosis, The exact purpose these enzymes occurrence evolution region (CC) is not clear. In order extract analyze relevant mRNA gene expression data as well clinical patient data, we used open databases. A reliable risk...
Abstract Purpose: We present a comprehensive systematic review of the documented literature on parameters derived from 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) and meta-analysis prognostic value maximal standard uptake (SUVmax), metabolic tumor volume (MTV) total lesional glycolysis (TLG) in patients with renal carcinoma (RCC). Patients methods: Relevant articles English PubMed, EMBASE, Cochrane Library were retrieved. Pooled hazard ratio (HR) values used to assess...
Adenoid cystic carcinoma is a rare malignant tumor of the salivary glands, with few reports metastasis to liver in literature. We present case where an isolated hepatic lesion adenoid was identified using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).
Abstract Background This study aimed to investigate the regulation of chloride channels in proliferative vitreoretinopathy (PVR) both vitro and vivo using a rabbit model explore underlying mechanism. Methods The channel was regulated by inhibitor NPPB activator lubiprostone. RPE cell proliferation migration were assessed CCK-8, scratch, Transwell assays. Collagen I, III, Fibronectin protein levels detected Western blotting. In study, or lubiprostone injected intravitreally induce PVR model....