A5008718650- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Spine and Intervertebral Disc Pathology
- Botulinum Toxin and Related Neurological Disorders
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Connective tissue disorders research
- Connective Tissue Growth Factor Research
- Pelvic and Acetabular Injuries
- Cardiac Fibrosis and Remodeling
- Neurological disorders and treatments
- Advanced Photocatalysis Techniques
- Complement system in diseases
- Polymer Surface Interaction Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Studies on Chitinases and Chitosanases
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
First Affiliated Hospital of Zhengzhou University
2015-2025
Zhengzhou University
2015-2024
Amsterdam Neuroscience
2023
Amsterdam University Medical Centers
2023
Vrije Universiteit Amsterdam
2023
Baoding People's Hospital
2020-2021
Central South University of Forestry and Technology
2020
Sir Run Run Shaw Hospital
2019-2020
Zhejiang University
2019-2020
Central South University
2020
The benefits of intravenous thrombolysis in patients with acute minor stroke remain controversial. For the aim providing a better therapeutic strategy, high-quality trials are required to validate efficacy thrombolytic medicine other than recombinant tissue plasminogen and tenecteplase. In trial, we evaluate safety urokinase (UK) stroke. This multicenter, open-label, blinded-endpoint, randomized controlled clinical trial enrolled within 6 h symptom onset, NIHSS score ≤ 5. was conducted at 25...
In the present work, a series of magnetically separable Fe3O4/g-C3N4/MoO3 nanocomposite catalysts were prepared. The as-prepared characterized by XRD, EDX, TEM, FT-IR, UV-Vis DRS, TGA, PL, BET and VSM. photocatalytic activity materials was evaluated catalytic degradation tetracycline solution under visible light irradiation. Furthermore, influences weight percent MoO3 scavengers reactive species on investigated. results showed that (30%) nanocomposites exhibited highest removal ability for...
MiR-198 is involved in tumorigenesis, migration, invasion, and metastasis of various malignant cancers. However, the exact expression levels miR-198 molecular mechanism underlying its role lung adenocarcinoma require further exploration. In this study, quantitative real-time PCR was applied to study serine hydroxymethyltransferase 1 (SHMT1) 47 paired tissues adjacent nontumor tissues. Clinicopathological characters were analyzed. Pearson’s correlation analysis used detect relationship...
Background: Recent studies have found deposition of phosphorylated α-synuclein (p-syn) in Parkinson disease (PD) patients' skin, indicating p-syn may be a potential biomarker PD. However, the sensitivity detection varied largely from 5. 3 to 100%, this influenced clinical use method some extent. Objective: This study aimed optimize skin biopsy for detecting patients with Methods: Ninety PD and 30 healthy controls underwent biopsies at 2-3 following sites: distal leg, thigh, cervical region,...
Toll-like receptors (TLRs) are important components of the innate and adaptive immune systems, abnormal TLR expression has been linked to a variety cancers. However, there was lack clarity on association stimulation with carcinogenesis cancer. The study's goal analyse clinical importance TLRs at mRNA level in pan-cancer datasets, as well link between carcinogenesis, progression, prognosis.The profile derived from UCSC data analysed multiple dimensions, including analysis, immunological...
Abstract Objective Recent studies demonstrated cutaneous phosphorylated α synuclein (p‐syn) deposition in idiopathic and some monogenetic Parkinson disease (PD) patients, suggesting synucleinopathy identical to that the brain. Although LRRK2 Gly2385Arg (G2385R) variant is a common PD risk factor Chinese population, pathogenesis of with G2385R has not been reported. We investigated whether small fiber neuropathy (SFN) are associated variant. Methods performed genotyping 59 patients 30 healthy...
Abstract: Puerarin is used to treat cardiovascular diseases due its anti-inflammatory and antifibrotic effects. However, mechanism of action in atrial fibroblasts unknown. In this study, we investigated the autophagy pathway molecular changes angiotensin II (AngII)-stimulated response puerarin treatment. Atrial were cultured then subjected stimulation with AngII or other chemical drugs (3-MA, CQ, SP600125). Quantitative real-time polymerase chain reaction Western blot experiments quantify...
Both specific and innate immune responses play important roles in autoimmune encephalitis (AE). We aimed to explore the predictive value of systemic inflammation index (SII) at admission as a peripheral biomarker treatment response AE. A total 146 patients diagnosed with AE First Affiliated Hospital Zhengzhou University from January 1, 2018 September 22, 2020 were retrospectively consecutively analyzed per inclusion criteria divided into two groups according their immunotherapy after 30...
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by CAG repeat expansion in the region of ATXN3 gene. The main feature SCA3 progressive ataxia, which affects balance, gait, and speech. Urine cells (UCs) patient were successfully translated to induced pluripotent stem (iPSCs) using Sendai virus delivery system. ZZUi004-A cell line may provide robust platform for further study pathogenesis as well drug testing gene therapy research.
Objective: To investigate and compare the effect of decompression fusion with internal fixation vs. simple in treatment elderly patients two-segment lumbar spinal stenosis (LSS) perioperative postoperative follow-up periods.
 Methods: Twenty-eight LSS admitted Baoding First Hospital between Mar. 2017 Jan. 2018 were retrospectively analyzed. Fifteen who underwent included group, 13 decompression-fixation group. The general data conditions including wound complications, operation time,...
To investigate and analyze the effect of percutaneous minimally invasive pedicle screw internal fixation in treatment thoracolumbar vertebral fractures its impact on quality life.Fifty patients with fracture admitted to our hospital from January 2015 December 2018 were selected divided into two groups according different regimens. The observation group was treated fixation, while control traditional posterior approach open fixation. surgery time, incision length, intraoperative blood loss,...
Background: Intravenous thrombolysis is increasingly used in patients following acute minor ischaemic stroke, but its benefit not yet clear. Urokinase as the first-generation intravenous thrombolytic drug, which was recommend UK for stroke China guidelines. However, efficacy and safety of remains unknown.Methods: This multicentre, open-label, blinded-endpoint, randomised clinical trial conducted across 25 hospitals China. Patients who presented with (National Institutes Health Stroke Scale...
Minor ischemic stroke attack has taken a significant part of cerebrovascular disease burden. Benefits thrombolysis in minor is under debates and the use urokinase developing countries needs to be further explored.TRUST (ThRombolysis Urokinase for STroke) trial was designed evaluate efficacy safety intravenous treatment acute stroke.To reach double-sided type I error rate 0.05 test our hypothesis, with β = 0.80, sample size 1002 subjects were determined after adjustment account up 5%...
Abstract Background: Atrial remodeling is a common pathological change in atrial fibrillation (AF), while the mechanism of remains unclear. In present study, we investigated autophagy and collagen secretion fibroblasts response to renin-angiotensin system (RAS) activation elucidated relationship between fibroblast remodeling. Methods: Right tissues was obtained from patients that underwent cardiac valve replacement after signed informed consent form. vivo, subcutaneous perfusion angiotensin...
Patients with dementia Lewy body(DLB), Alzheimer disease (AD), frontotemporal (FTP), progressive supranuclear palsy (PSP) and healthy controls in the Department of Neurology, First Affiliated Hospital Zhengzhou University from August 2019 to March 2021 were recruited, 3 each group. Phosphorylated α-synuclein skin DLB patients was detected by micro-biopsy compared AD, FTP, PSP health controls. found nerves patients, while no samples others. Skin phosphorylated may potentially become a...
Abstract Background A precise understanding of the neuroanatomical basis clinical manifestation dementia is an important step for timely diagnosis. Dementia due to proteinopathies, such as Alzheimer’s disease (AD), with Lewy bodies (DLB), and Frontotemporal (FTD), have different yet overlapping atrophy patterns which could account their presentations. To disentangle these relationships facilitate differential diagnosis, we estimated distinct associated them cognitive deficits. Method We...