A5020465769- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Cancer-related cognitive impairment studies
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Voice and Speech Disorders
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Health, psychology, and well-being
- Frailty in Older Adults
- Aging, Elder Care, and Social Issues
- Mental Health Research Topics
- Statistical Methods in Clinical Trials
- Geriatric Care and Nursing Homes
- Technology Use by Older Adults
- Cognitive Functions and Memory
- Music Therapy and Health
- Patient-Provider Communication in Healthcare
- Intensive Care Unit Cognitive Disorders
- Health and Wellbeing Research
- Language Development and Disorders
- Older Adults Driving Studies
- Chronic Disease Management Strategies
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
Brigham and Women's Hospital
2022-2025
Amsterdam Neuroscience
2020-2024
Amsterdam University Medical Centers
2020-2024
Vrije Universiteit Amsterdam
2020-2024
National Brain Research Centre
2023
University College London
2022
GGD Amsterdam
2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2022
It is unclear to what extent cognitive outcome measures are sensitive capture decline in Alzheimer disease (AD) prevention trials. We aimed analyze the sensitivity changes over time of a range neuropsychological tests several cognitively unimpaired, biomarker-defined patient groups.
Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi-day digital testing to characterize LTF and investigated its association with initial learning AD imaging biomarkers. One hundred four cognitively unimpaired completed a face-name task seven consecutive days were asked recognize pairs 1 week later. was computed as the number correctly identified stimuli divided by...
Abstract Background Impairment in daily functioning is a clinical hallmark of dementia. Difficulties with “instrumental activities living” (IADL) seem to increase gradually over the course Alzheimer’s disease (AD), before dementia onset. However, it currently not well established how difficulties develop along preclinical and prodromal stages AD. We aimed investigate trajectories decline IADL performance, as reported by study partner, early Methods In longitudinal multicenter study,...
Self-perceived cognitive functioning, considered highly relevant in the context of aging and dementia, is assessed numerous ways-hindering comparison findings across studies settings. Therefore, present study aimed to link item-level self-report questionnaire data from international studies.
Abstract Background Emerging difficulty performing cognitively complex everyday tasks, or ‘instrumental activities of daily living’ (IADL) may be an early clinical sign Alzheimer’s disease (AD). We aimed to investigate how changes over time in functioning relate cerebral tau burden across the AD spectrum. Methods included 581 participants (73.9 ± 7.6 years old; 52% female) from Disease Neuroimaging Initiative who underwent positron emission tomography (PET) and completed at least two...
Introduction To understand the potential influence of diversity on measurement functional impairment in dementia, we aimed to investigate possible bias caused by age, gender, education, and cultural differences. Methods A total 3571 individuals (67.1 ± 9.5 years old, 44.7% female) from The Netherlands, Spain, France, United States, Kingdom, Greece, Serbia, Finland were included. Functional was measured using Amsterdam Instrumental Activities Daily Living (IADL) Questionnaire. Item assessed...
Decline in everyday functioning is a key clinical change Alzheimer disease and related disorders (ADRD). An important challenge remains the determination of what constitutes clinically meaningful functioning. We aimed to investigate this by establishing minimal (MIC): smallest amount that has effect on patients' lives. retrospectively investigated memory clinic cohort.In first, qualitative part study, community-recruited informal caregivers patients with ADRD clinicians completed survey...
Abstract Background Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) pathology acoustics measured over multiple assessments a remote setting. Methods Fifty cognitively unimpaired adults (Age 68 ± 6.2 years, 58% female, 46% Aβ-positive) completed remote, tablet-based (i.e., picture description, journal-prompt storytelling,...
Everyday functioning is a clinically relevant concept in dementia, yet little known about the clinical meaningfulness of scores on functional outcome measures. We aimed to establish meaningful scoring categories for Amsterdam Instrumental Activities Daily Living Questionnaire (A-IADL-Q), representing no, mild, moderate and severe problems daily functioning.Informal caregivers (n = 6) memory-clinic patients clinicians 13), including neurologists nurse specialists, working at various memory...
Introduction: Impaired awareness in dementia caused by Alzheimer's disease and related disorders made study partner-report the preferred method of measuring interference "instrumental activities daily living" (IADL). However, with a shifting focus toward earlier stages prevention, question arises whether self-report might be equally or even more appropriate. The aim this was to investigate how participant- IADL perform community-based volunteer population without which factors relate...
The Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) is well validated and commonly used to assess difficulties in everyday functioning regarding dementia. To facilitate interpretation clinical implementation across different European countries, we aim provide normative data a diagnostic cutoff for
Abstract Background Heightened public awareness about Alzheimer's disease and dementia increases the need for at‐home cognitive self‐testing. We offered Cognitive Online Self‐Test Amsterdam (COST‐A) to independent groups of cognitively normal adults investigated robustness a norm‐score formula cutoff. Methods Three thousand eighty‐eight participants (mean age ± standard deviation = 61 12 years, 70% female) completed COST‐A evaluated it. Demographically adjusted norm scores were difference...
Abstract Background Instrumental Activities of Daily Living (IADL) limitations are associated with reduced health-related quality life for people mild cognitive impairment (MCI). For these people, the assessment IADL is crucial to diagnostic process, as well evaluation new interventions addressing MCI. The Amsterdam Questionnaire Short Version (A-IADL-Q-SV) an established tool good psychometric properties that has been shown be robust cultural differences in Western countries. aims this...
Abstract INTRODUCTION To investigate the utility of a new digital tool for measuring everyday functioning in preclinical Alzheimer's disease, we piloted Assessment Smartphone Everyday Tasks (ASSET) application. METHODS Forty-six participants (50.3 ± 27.1 years; 67% female; 20 young unimpaired, 17 old 9 mildly cognitively impaired) completed ASSET 7 times. comprises two main tasks, simulating Patient Portal and Calendar. We assessed ASSET's internal consistency, test–retest reliability, user...
Abstract Background Assessment of self‐perceived cognitive decline (SCD) is relevant in the context Alzheimer’s disease and related disorders, but heterogeneity measurement limits its interpretability usability. Selection optimal content for a questionnaire measuring SCD requires statistical information expert opinion to ensure reliability as well acceptability feasibility. This study aims survey experts about their perspectives on essential features measurement. Method The was distributed...
Abstract Background Emerging difficulty performing cognitively complex everyday tasks, or ‘instrumental activities of daily living’ (IADL) may be an early clinical sign Alzheimer’s disease (AD). We aimed to investigate how changes over time in functioning relate tau across the AD spectrum. Method included 581 participants (73.9±7.6 years old; 52% female) from Disease Neuroimaging Initiative who underwent positron emission tomography (PET) and completed at least two assessments Functional...
We investigated how well a visual associative learning task discriminates Alzheimer's disease (AD) dementia from other types of and it relates to AD pathology.
Abstract With the advent of first generation disease‐modifying treatments for Alzheimer's disease, it is clearer now more than ever that field needs to move toward personalized medicine. Pooling data from past trials may help identify subgroups most likely benefit specific and thus inform future trial design. In this perspective, we report on our effort pool disease patients respond different treatments. We delineate challenges hurdles, proof‐of‐principle study, which requested access...
Background Changes in everyday functioning constitute a clinically meaningful outcome, even the early stages of Alzheimer's disease. Performance-based assessments might help uncover these changes. We aimed to investigate how changes over time relate tau and amyloid cognitively unimpaired older adults. Methods Seventy-six participants (72 ± 6 years old, 61% female) completed multiple Harvard Automated Phone Task (APT) 2.0 0.9 years. The APT consists three tasks, performed through an automated...
Abstract Objectives: We aimed to compare and link the total scores of Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA), two common global cognitive screeners. Methods: 2,325 memory clinic patients (63.2 ± 8.6 years; 43% female) with a variety diagnoses, including subjective decline, mild impairment, dementia due various etiologies completed MMSE MoCA concurrently. described both screeners, at item level. Then, using linear regressions, we investigated how age, sex,...
Abstract Background Orientation in time, space, and person is often impaired Alzheimer’s disease dementia. Subtle changes orientation may occur prodromal preclinical stages. Here we aim to assess the cross‐sectional association between individuals’ their own world, as measured with a novel AI‐based paradigm, biomarkers (amyloid tau) cognitively unimpaired older adults. Methods Using an automated chatbot, 51 participants (74.2 ± 5.3 years, 57% female) provided details about personal memories...
Abstract Background Automated analysis of natural speech is emerging as a promising digital biomarker Alzheimer’s disease (AD). As complex process, relying on multiple interacting cognitive functions, fine‐grained may have the potential to capture subtle deficits in very early stages AD. Here, we examined association between amyloid‐beta (Aβ) pathology and acoustic characteristics group cognitively normal Dutch adults. Method We included 50 (n = 23 Aβ‐positive, 46%) older adults from three...
Abstract Background Accelerated long‐term forgetting (LTF) is characterized by unimpaired retention of information after short‐term delays (e.g., 20‐30 minutes) with increased at longer intervals weeks to months). Previous studies have suggested that assessing LTF may provide a useful marker preclinical Alzheimer’s disease (AD). However, over challenging using standardized in‐clinic paper‐pencil cognitive tests. Here, we leverage remote, digital testing investigate different timepoints and...