A5036693832- Dementia and Cognitive Impairment Research
- Aging and Gerontology Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Migration, Health and Trauma
- Cerebrovascular and Carotid Artery Diseases
- Geriatric Care and Nursing Homes
- Ethics in Clinical Research
- EEG and Brain-Computer Interfaces
- Posttraumatic Stress Disorder Research
- Health disparities and outcomes
- Grit, Self-Efficacy, and Motivation
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neurobiology of Language and Bilingualism
- Digital Mental Health Interventions
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury Research
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Patient-Provider Communication in Healthcare
University of California, Davis
2014-2025
VA Northern California Health Care System
2013
UC Davis Health System
2009
University of California Davis Medical Center
2008
<h3>Background</h3> Mild cognitive impairment is increasingly recognized as an important public health problem associated with increased risk of developing dementia. Annual conversion rates, however, vary across different studies clinic samples showing higher rates than community-based samples. <h3>Objectives</h3> To establish whether the from mild to dementia differed according recruitment source and, if so, investigate factors that might explain this discrepancy. <h3>Design</h3> Rates and...
<h3>Objective:</h3> Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length the normal repeat allele has been reported also to influence age onset, interaction allele. Due profound implications for mechanism and modification, we tested whether allele, between alleles, or presence a second affects HD signs. <h3>Methods:</h3> We modeled natural log-transformed as function lengths alleles their by...
Vitamin D (VitD) deficiency is associated with brain structural abnormalities, cognitive decline, and incident dementia.
Abstract Background This study describes the development and validation of a shortened version Everyday Cognition (ECog) scales [Tomaszewski Farias et al. Neuropsychology 2008;22:531–44], an informant‐rated questionnaire designed to detect cognitive functional decline. Methods External, convergent, divergent validities internal consistency were examined. Data derived from informant ratings 907 participants who either cognitively normal, had mild impairment (MCI), or dementia. Results Twelve...
This study examined trajectories of cognitive change in psychometrically matched measures episodic memory, semantic and executive function an ethnically, demographically, cognitively diverse sample older persons. Individual rates showed considerable heterogeneity each domain. Baseline clinical diagnosis predicted differential memory function, dementia > mild impairment (MCI) normal, but average decline verbal was similar across all 3 diagnostic groups. There substantial overlap distributions...
Abstract Cognitive reserve is thought to reflect life experiences. Which experiences contribute and their relative importance not understood. Subjects were 652 autopsied cases from the Rush Memory Aging Project Religious Orders Study. Reserve was defined as residual variance of regressions cognitive factors on brain pathology captured in a latent variable that regressed potential determinants reserve. Neuropathology variables included Alzheimer's disease markers, Lewy bodies, infarcts,...
The purpose of this study was to evaluate how demographic variables relate cognitive change and address whether cross-sectional effects on tests are mirrored in differences longitudinal trajectories decline.We hypothesized that race ethnicity, education, language test administration would status the rate decline differ among African Americans, Hispanics, Caucasians, across levels educational attainment, according linguistic background.Participants were 404 educationally, ethnically,...
Abstract Neurocognitive deficits in fragile X‐associated tremor/ataxia syndrome (FXTAS) involve attentional control, working memory, executive functioning, and declarative procedural learning. To date, no studies comparing FXTAS with other dementias have been done. We characterize the dementia FXTAS, it Alzheimer's disease. Retrospective chart review of 68 adults (50 men, 18 women) FXTAS. 20 men were matched by age, gender, education to patients mild (AD). Neuropsychological measures...
Abstract The recently developed Everyday Cognition scales (ECog) measure multiple cognitively relevant functional domains (e.g., Memory, Language, Visuospatial abilities, and three everyday executive domains). present study further evaluated the validity of ECog by examining its relationship with objective measures neuropsychological function, neurobiological markers disease as reflected structural neuroimaging. Participants included 474 older adults (244 normals, 142 MCI, 88 dementia)....
Abstract Older adults with early forms of neurodegenerative disease are at risk for functional disability, which is often defined by the loss independence in instrumental activities daily living (IADLs). The current study investigated influence mild changes everyday abilities (referred to as limitations) on development incident disability. A total 407 participants, who were considered cognitively normal or diagnosed cognitive impairment (MCI) baseline, followed longitudinally over an average...
Background/Rationale: Compensation strategies may contribute to greater resilience among older adults, even in the face of cognitive decline. This study sought better understand how compensation strategy use adults with varying degrees impairment impacts everyday functioning. Methods: In all, 125 (normal cognition, mild impairment, dementia) underwent neuropsychological testing, and their informants completed questionnaires regarding functional abilities. Results: Cognitively normal had...
Comparability of meaning neuropsychological test results across ethnic, linguistic, and cultural groups is important for clinicians challenged with assessing increasing numbers older ethnic minorities. We examined the dimensional structure a battery in linguistically demographically diverse adults.The Spanish English Neuropsychological Assessment Scales (SENAS), developed to provide psychometrically sound measures cognition multiethnic multilingual applications, was administered community...
The everyday functional capacities of older adults are determined by multiple factors. primary goal the present study was to evaluate whether apathy and depression have unique influences on degree impairment, independent effects specific cognitive impairments. Participants included 344 (199 normal, 87 with MCI, 58 dementia). Everyday Cognition (ECog) scales were used measure both global domain-specific abilities. Neuropsychiatric symptoms measured Inventory (NPI), neuropsychological domains...
Abstract INTRODUCTION We evaluated preliminary feasibility of a digital, culturally‐informed approach to recruit and screen participants for the Alzheimer's Disease Neuroimaging Initiative (ADNI4). METHODS Participants were recruited using digital advertising completed surveys (e.g., demographics, medical exclusion criteria, 12‐item Everyday Cognition Scale [ECog‐12]), Novoic Storyteller speech‐based cognitive test). Completion rates assessment performance compared between underrepresented...
Abstract Objectives Vietnamese Americans are the fourth-largest Asian subgroup in United States (US), but little qualitative work has been done on their war and migration experiences. In this study, we delineated war-related traumas strength participants of Insights into Cognitive Aging Program (VIP). Methods VIP is a longitudinal study 548 aged 65+ years living Northern California. During visit 1, semi-structured interview was conducted participants’ life experiences Vietnam immigration to...
Positive psychological characteristics may help to bolster daily functioning in older adults even the presence of subjective or subtle objective cognitive weaknesses. The purpose present study was examine which specific contribute better functional abilities, independent performance, among a sample with decline (SCD). Participants included 277 recruited from community who were enrolled randomized controlled trial examining impact training memory support strategies and healthy lifestyle...
Background/Objective:To determine the impact of vascular burden on rates decline in episodic memory and executive function. We hypothesize that greater will have an additive negative cognition after accounting for baseline cognitive impairment, positron emission tomogra phy (PET) amyloid burden, magnetic resonance imaging (MRI) measures. Methods:Individuals were followed average 5 years with serial assessments. Predictor variables include score (VBS), quantitative brain MRI assessment,...
Abstract Background Impairment in daily functioning is a clinical hallmark of dementia. Difficulties with “instrumental activities living” (IADL) seem to increase gradually over the course Alzheimer’s disease (AD), before dementia onset. However, it currently not well established how difficulties develop along preclinical and prodromal stages AD. We aimed investigate trajectories decline IADL performance, as reported by study partner, early Methods In longitudinal multicenter study,...
Prior research has shown that some personality traits are associated with cognitive outcomes and may confirm risk or protection against decline. The present study expands on previous work to examine the association between a more comprehensive set of psychological characteristics performance in diverse cohort older adults. We also whether controlling for brain atrophy influences function. A total 157 adults completed battery questionnaires (Openness Experience, Conscientiousness,...
Background: Cognitive impairment, including dementia, is frequently under-detected in primary care. The Consortium for Detecting Impairment, Dementia (DetectCID) convenes three multidisciplinary teams that are testing novel paradigms to improve the frequency and quality of patient evaluations detecting cognitive impairment care appropriate follow-up. Objective: Our objective was characterize paradigms, similarities differences, identify common key lessons from implementation. Methods: A...
Introduction Composite scores based on psychometrically rigorous cognitive assessments are well suited for early diagnosis and disease monitoring. Methods We developed cross-validated the Brain Health Assessment-Cognitive Score (BHA-CS), a brief computerized battery, in 451 cognitively normal (CN) 399 impaired (mild impairment [MCI] or dementia) older adults. investigated its long-term reliability reliable change indices at longitudinal follow-up (N = 340), association with amyloid beta (Aβ)...
Abstract The brain signature concept aims to characterize regions most strongly associated with an outcome of interest. Brain signatures derive their power from data-driven searches that select features based solely on performance metrics prediction or classification. This approach has important potential delineate biologically relevant substrates for classification future trajectories. Recent work used exploratory voxel-wise atlas-based searches, some using machine learning techniques...