A5082228880- Attention Deficit Hyperactivity Disorder
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Mental Health Research Topics
- Digital Mental Health Interventions
- Child and Adolescent Psychosocial and Emotional Development
- Chronic Disease Management Strategies
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Genetic Associations and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Tryptophan and brain disorders
- Machine Learning in Healthcare
- Cognitive Functions and Memory
- Autism Spectrum Disorder Research
- Smoking Behavior and Cessation
- Ethics in Clinical Research
- Birth, Development, and Health
- EEG and Brain-Computer Interfaces
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Adolescent and Pediatric Healthcare
- Interpreting and Communication in Healthcare
Cambridge Cognition (United Kingdom)
2018-2024
University of Bristol
2019-2024
Great Ormond Street Hospital
2011-2019
University College London
2011-2019
Great Ormond Street Hospital for Children NHS Foundation Trust
2019
King's College London
2009-2016
Psychiatry Research Trust
2009
Abstract Background There is evidence to suggest that the broad discrepancy in ratio of males females with diagnosed ADHD due, at least part, lack recognition and/or referral bias females. Studies present differences their profile symptoms, comorbidity and associated functioning compared males. This consensus aims provide a better understanding order improve referral. Comprehensive assessment appropriate treatment hoped enhance longer-term clinical outcomes patient wellbeing for ADHD....
<h3>Objective:</h3> Temporal lobe resection is an established treatment for medication-resistant temporal epilepsy, which in recent years has increasingly been performed children. However, little known about the long-term outcome these The aim of this study was to characterize intellectual and psychosocial functioning children after as they progress into late adolescence adulthood. <h3>Methods:</h3> We report follow-up 42 who underwent surgery average postoperative period 9 years....
Objective: This study investigates excessive mind wandering (MW) in adult ADHD using a new scale: the Mind Excessively Wandering Scale (MEWS). Method: Data from two studies of was used assessing psychometric properties MEWS. Case-control differences MW, association with symptoms, and contribution to functional impairment were investigated. Results: The MEWS functioned well as brief measure MW ADHD, showing good internal consistency (α > .9), high sensitivity (.9) specificity for...
The temporal lobes play a prominent role in declarative memory function, including episodic (memory for events) and semantic facts concepts). Surgical resection medication-resistant well-localized lobe epilepsy has good prognosis seizure freedom, but is linked to difficulties adults, especially when the removal on left side. Children may benefit most from surgery, because brain plasticity facilitate post-surgical reorganization, cessation promote cognitive development. However, long-term...
Background Computerized assessments are already used to derive accurate and reliable measures of cognitive function. Web-based assessment could improve the accessibility flexibility research clinical assessment, widen participation, promote recruitment while simultaneously reducing costs. However, differences in context may influence task performance. Objective This study aims determine comparability an unsupervised, web-based administration Cambridge Neuropsychological Test Automated...
Abstract There is increasing evidence that abnormalities in glutamate signalling may contribute to the pathophysiology of attention-deficit hyperactivity disorder (ADHD). Proton magnetic resonance spectroscopy ([1H]MRS) can be used measure glutamate, and also its metabolite glutamine, vivo . However, few studies have investigated brain adults with ADHD naive stimulant medication. Therefore, we [1H]MRS combined signal glutamine (Glu+Gln; abbreviated as Glx) along other neurometabolites such...
Background: Despite evidence-based national guidelines for ADHD in the United Kingdom (UK), is under-identified, under-diagnosed, and under-treated. Many seeking help face prejudice, long waiting lists, patchy or unavailable services, are turning to service-user support groups and/or private healthcare help. Methods: A group of UK experts representing clinical providers from public healthcare, academia, patient groups, educational, occupational specialists, met discuss shortfalls service...
Background Cognitive symptoms are common in major depressive disorder and may help to identify patients who need treatment or not experiencing adequate response. Digital tools providing real-time data assessing cognitive function could support patient remediation of mood symptoms. Objective The aim this study was examine feasibility validity a wearable high-frequency assessment app over 6 weeks, corresponding when antidepressant pharmacotherapy begins show efficacy. Methods A total 30 (aged...
ADHD in adults is a common and debilitating neurodevelopmental mental health condition. Yet, diagnosis, clinical management monitoring are frequently constrained by scarce resources, low capacity specialist services limited awareness or training both primary secondary care. As result, many people with experience serious barriers accessing the care they need.Professionals across primary, secondary, tertiary met to discuss adult United Kingdom. Discussions identified constraints service...
Background Recent literature on the comparison of machine learning methods has raised questions about neutrality, unbiasedness and utility many comparative studies. Reporting results favourable datasets sampling error in estimated performance measures based single samples are thought to be major sources bias such comparisons. Better one or a few instances does not necessarily imply so an average population level simulation studies may better alternative for objectively comparing performances...
Background. Emotional lability (EL), characterized by negative emotional traits and instability, is frequently reported in children adults with attention deficit hyperactivity disorder (ADHD). However, EL primarily assessed using retrospective self-report, which subject to reporting bias does not consider the potential influence of positive everyday experiences. Method. Ambulatory assessment was carried out 41 men ADHD without co-morbidity, current medication or substance abuse, 47 healthy...
Abstract INTRODUCTION We evaluated preliminary feasibility of a digital, culturally‐informed approach to recruit and screen participants for the Alzheimer's Disease Neuroimaging Initiative (ADNI4). METHODS Participants were recruited using digital advertising completed surveys (e.g., demographics, medical exclusion criteria, 12‐item Everyday Cognition Scale [ECog‐12]), Novoic Storyteller speech‐based cognitive test). Completion rates assessment performance compared between underrepresented...
Summary Objective Intelligence quotient (IQ) outcomes after pediatric epilepsy surgery show significant individual variation. Clinical factors such as seizure cessation or antiepileptic medication discontinuation have been implicated, but do not fully account for the heterogeneity seen. Less is known about impact of neurobiological factors, brain development and resection location. This study examines clinical neuroimaging associated with cognitive outcome in childhood. Methods Fifty‐two...
Story recall is a simple and sensitive cognitive test that commonly used to measure changes in episodic memory function early Alzheimer disease (AD). Recent advances digital technology natural language processing methods make this candidate for automated administration scoring. Multiple parallel stimuli are required higher-frequency monitoring.This study aims develop validate remote fully story task, suitable longitudinal assessment, population of older adults with without mild impairment...
Normative cognitive data can help to distinguish pathological decline from normal aging. This study presents normative the Cambridge Neuropsychological Test Automated Battery, using linear regression and nonlinear quantile approaches.Heinz Nixdorf Recall participants completed Battery tests: paired-associate learning, spatial working memory, reaction time. Data were available for 1349-1529 healthy adults aged 57-84 years. Linear analyses examined age-related changes, adjusting sex education....
Anxiety and depression are associated with a range of impairments in cognitive functioning. Understanding the nature these deficits may identify targets for intervention prevent functional decline. We used observational genetic methods to investigate relationship anxiety three domains: emotion recognition, response inhibition, working memory, Avon Longitudinal Study Parents Children (ALSPAC). examined: (i) cross-sectional associations between anxiety, depression, cognition at age 24 (n =...
There have been few longitudinal studies of association between alcohol use and cognitive functioning in young people. We aimed to examine whether is a causal risk factor for deficient adults.Linear regression was used the relationship latent class patterns binge drinking subsequent functioning. Two-sample Mendelian randomization (MR) tested evidence functioning.South West England.The observational study included 3155 adolescents their parents (fully adjusted models) from Avon Longitudinal...
Abstract Background Emotional dysregulation (ED) is a core diagnostic symptom in borderline personality disorder (BPD) and an associated feature of attention-deficit/hyperactivity (ADHD). We aimed to investigate differences dynamical indices ED daily life ADHD BPD. Methods used experience sampling method (ESM) multilevel modelling assess momentary changes reports affective symptoms, retrospective questionnaire measures sample 98 adult females with ADHD, BPD, comorbid ADHD+BPD healthy...