A5053342071- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Bioinformatics and Genomic Networks
- Mindfulness and Compassion Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Complementary and Alternative Medicine Studies
- Functional Brain Connectivity Studies
- Cosmology and Gravitation Theories
- Geriatric Care and Nursing Homes
- Astronomy and Astrophysical Research
- Neurological diseases and metabolism
- Ginkgo biloba and Cashew Applications
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Electroconvulsive Therapy Studies
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Aging, Elder Care, and Social Issues
Amsterdam Neuroscience
2019-2024
Amsterdam University Medical Centers
2019-2024
Vrije Universiteit Amsterdam
2019-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2023
University of Amsterdam
2023
University College London
2022
Istituto delle Scienze Neurologiche di Bologna
2021
University of Bologna
2021
National Institute of Allergy and Infectious Diseases
2021
Radboud University Nijmegen
2013-2017
To investigate whether the CSF α-synuclein (α-syn) real-time quaking-induced conversion (RT-QuIC) assay accurately identifies patients with mild cognitive impairment (MCI) due to probable Lewy body (LB) disease.We applied α-syn RT-QuIC 289 samples obtained from 2 independent cohorts, including 81 MCI-LB (age 70.7 ± 6.6 years, 13.6% female, Mini-Mental State Examination [MMSE] score 26.1 2.4), 120 MCI Alzheimer disease (AD) 68.6 7.4 45.8% MMSE 25.5 2.8), and 30 unspecified 65.4 9.3 30.0% 27.0...
Background: The recent COVID-19 pandemic is not only a major healthcare problem in itself, but also poses enormous social challenges. Though nursing homes increasingly receive attention, the majority of people with cognitive decline and dementia live at home. We aimed to explore psychosocial effects corona measures memory clinic (pre-)dementia patients their caregivers. Methods: Between April 28th July 13th 2020, n = 389 Alzheimer center Amsterdam [n 121 symptomatic (age 69 ± 6, 33%F, MMSE...
Abstract Objective The objective of this study was to examine clinical characteristics, cognitive decline, and predictors for time dementia in prodromal with Lewy bodies mild impairment (MCI‐LB) compared Alzheimer's disease (MCI‐AD). Methods We included 73 MCI‐LB patients (12% female; 68 ± 6 years; Mini Mental State Examination, 27 2) 124 MCI‐AD (48% 7 from the Amsterdam Dementia Cohort. Follow‐up available 61 all (3 2 years). evaluated core features, neuropsychiatric symptoms, caregiver...
Abstract Dementia with Lewy bodies (DLB) is a neurodegenerative disorder wide heterogeneity of symptoms, which suggests the existence different subtypes. We used data-driven analysis magnetic resonance imaging (MRI) data to investigate DLB included 165 from Mayo Clinic and 3 centers European consortium performed hierarchical cluster identify subtypes based on gray matter (GM) volumes. To characterize subtypes, we demographic clinical data, as well β-amyloid, tau, cerebrovascular biomarkers...
The ATN framework has been developed to categorize biological processes within the Alzheimer disease (AD) continuum. Because AD pathology often coincides with dementia Lewy bodies (DLB), we aimed investigate distribution of profiles in DLB and associate prognosis.We included 202 patients from Amsterdam Dementia Cohort (68±7 years; 19% female; Mini-Mental State Examination 24 ± 3; abnormal DAT-SPECT 105/119). Patients were classified into 8 according framework, using CSF β-amyloid (Aβ)42 (A),...
<h3>Objective</h3> Early biomarkers for dementia with Lewy bodies (DLB) are lacking. To determine whether EEG differentiates the prodromal phase of DLB from other causes mild cognitive impairment (MCI) and is predictive time to conversion MCI DLB, we compared EEGs clinical follow-up patients due those Alzheimer disease (MCI-AD). <h3>Methods</h3> We 37 who developed during or had an abnormal <sup>123</sup>I-PF-CIT SPECT scan (MCI-DLB) 67 age-matched MCI-AD. were assessed visually a score...
Quality of Life (QoL) is an important outcome measure in dementia, particularly the context interventions. Research investigating longitudinal QoL dementia with Lewy bodies (DLB) currently lacking.To investigate determinants and trajectories DLB compared to Alzheimer's disease (AD) controls.QoL was assessed annually 138 individuals, using EQ5D-utility-score (0-100) health-related Visual Analogue Scale (VAS, 0-100). Twenty-nine patients (age 69±6), 68 AD 70±6), 41 controls 70±5) were selected...
Abstract Background Dementia with Lewy bodies (DLB) is more prevalent in men than women. In addition, post-mortem studies found sex differences underlying pathology. It remains unclear whether these are also present antemortem vivo biomarkers, and translate to variability clinical manifestation. The objective of this study was evaluate cerebrospinal fluid (CSF) biomarker concentrations (i.e., alpha-synuclein (α-syn), amyloid β1-42 (Aβ42), total tau (Tau), phosphorylated at threonine 181...
Abstract Background The DEmEntia with LEwy bOdies Project (DEvELOP) aims to phenotype patients dementia Lewy bodies (DLB) and study the symptoms biomarkers over time. Here, we describe design baseline results of DEvELOP. We investigated associations between core suggestive DLB different aspects disease burden, i.e., instrumental activities daily living (IADL) functioning, quality life (QoL), caregiver burden. Methods included 100 (69 ± 6 years, 10%F, MMSE 25 3) in prospective DEvELOP cohort....
Recently, the US Food and Drug Administration approved tau-binding radiotracer [
Abstract Background Dementia with Lewy bodies (DLB) includes various core clinical features that result in different phenotypes. In addition, Alzheimer’s disease (AD) and cerebrovascular pathologies are common DLB. All this increases the heterogeneity within DLB hampers diagnosis. We addressed by investigating subgroups of patients similar biological, clinical, demographic features. Methods studied 107 extensively phenotyped from European consortium. Factorial analysis mixed data (FAMD) was...
Background: Dementia with Lewy bodies (DLB) is a complex, progressive neurodegenerative disease considerable phenotypic, pathological, and genetic heterogeneity. Objective: We tested if variants in part explain the heterogeneity DLB. Methods: effects of previously associated DLB (near APOE, GBA, SNCA) polygenic risk scores for Alzheimer’s (AD-PRS) Parkinson’s (PD-PRS). studied 190 probable patients from dementia cohort compared them to 2,552 control subjects. The p-tau/Aβ1–42 ratio...
Background: The COVID-19 pandemic poses enormous social challenges, especially during lockdown. People with cognitive decline and their caregivers are particularly at risk of lockdown consequences. Objective: To investigate psychosocial effects in (pre-)dementia patients second compare between first Methods: We included n = 511 826 from the Amsterdam Dementia Cohort via Alzheimer Nederland. All respondents completed a self-designed survey on COVID-19. examined relations experienced support...
Alpha-synuclein often co-occurs with Alzheimer's disease (AD) pathology in Dementia Lewy Bodies (DLB). From a dynamic [18F]flortaucipir PET scan we derived measures of both tau binding and relative cerebral blood flow (rCBF). We tested whether regional or rCBF differed between DLB patients AD controls examined their association clinical characteristics DLB. Eighteen probable DLB, 65 50 underwent 130-minute scan. positive biomarkers for based on cerebrospinal fluid amyloid were considered as...
Abstract Background and Objectives Dementia with Lewy Bodies (DLB) is a heterogeneous disease, variable signs symptoms across multiple domains. We aimed to identify associations rate of change in cognition, everyday functioning (IADL) quality life (QoL). Methods included 121 DLB patients (69 ± 6 yrs, 14%F, MMSE: 25 3) our prospective cohort (follow‐up 2 1 yrs). described progression cognitive decline over time. Mixed models were used investigate whether changes associated IADL (FAQ), QoL...
Article Abstract Objective: To investigate which neuropsychological tests can discriminate between behavioral variant frontotemporal dementia (bvFTD) and psychiatric disorders presenting with similar late-onset frontal changes, such as apathy, disinhibition, reduced empathy, or compulsive behavior. Methods: Patients changes in middle late adulthood received extensive baseline examinations, including assessment brain imaging. After 2 years, examinations were repeated patients diagnosed...
The nature of the dark sector Universe remains one outstanding problems in modern cosmology, with search for new observational probes guiding development next generation facilities. Clues come from tension between predictions {\Lambda}CDM and observations gravitationally lensed galaxies. Previous studies showed that galaxy clusters are not strong enough to reproduce observed number arcs. This work aims constrain warm matter cosmologies by means lensing efficiency drawn these alternative...
Abstract Background Dementia with Lewy Bodies (DLB) is characterized by the presence of neuronal inclusions containing alpha‐synuclein proteins, and often co‐occurs Alzheimer’s disease (AD) pathology. We aimed to determine pattern tau pathology relative cerebral blood flow (rCBF) in DLB, compared AD controls, their association cognitive impairment using a single dynamic [ 18 F]flortaucipir PET scan. Method Eighteen patients DLB (66 ± 8 years, MMSE 25 4, 44% amyloid positive (abnormal CSF...
Abstract Background Diagnosing dementia with Lewy bodies (DLB) is challenging due to overlapping clinical and cognitive presentation Alzheimer’s disease (AD). Web‐based assessments could aid by providing remote easily accessible diagnostic tools. In this study, we adapted a web‐based test tool, cCOG, adding visuospatial brief survey assessed its ability differentiate between DLB AD. Method We included 110 patients (67±7 years, 44% female, MMSE 26±4; n = 30 DLB, 32 AD 48 controls subjective...
Abstract Objectives: We aimed to compare and link the total scores of Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA), two common global cognitive screeners. Methods: 2,325 memory clinic patients (63.2 ± 8.6 years; 43% female) with a variety diagnoses, including subjective decline, mild impairment, dementia due various etiologies completed MMSE MoCA concurrently. described both screeners, at item level. Then, using linear regressions, we investigated how age, sex,...
It is currently unknown whether patients with dementia Lewy bodies (DLB) relatives or Parkinson's disease (familial DLB patients) have a different phenotype than sporadic patients.In this study, we aimed to examine onset, rate of cognitive decline, survival and Alzheimer's (AD) biomarkers in family history DLB, n = 154) (n 137), using linear mixed model analysis Cox regression analysis, among others.Familial had shorter (8.0 years) more often elevated cerebrospinal fluid AD (47%) (9.0 years;...
Abstract Background Dementia with Lewy bodies (DLB) is a neurodegenerative disorder that presents variety of clinical symptoms. Part the heterogeneity within DLB has been related to atrophy/sparing hippocampus. We extended previous research by investigating whether different atrophy patterns exist in DLB, beyond and above hippocampus, those contribute DLB. aimed identify subtypes using hypothesis‐free data‐driven clustering approach based on regional gray matter (GM) volumes characterize...