A5073943967- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Body Composition Measurement Techniques
- S100 Proteins and Annexins
- Brain Tumor Detection and Classification
- Optical Imaging and Spectroscopy Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Health, Environment, Cognitive Aging
- Statistical Methods in Clinical Trials
- Epilepsy research and treatment
- Cancer-related cognitive impairment studies
- Cognitive Functions and Memory
- Parkinson's Disease Mechanisms and Treatments
Amsterdam Neuroscience
2016-2023
Amsterdam University Medical Centers
2018-2023
Vrije Universiteit Amsterdam
2010-2023
University College London
2020-2021
Lund University
2021
University Medical Center
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2010-2020
Karolinska Institutet
2020
Maastricht University
2020
Neurology, Inc
2017
<h3>Objective</h3> To investigate the relationship between ATN classification system (amyloid, tau, neurodegeneration) and risk of dementia cognitive decline in individuals with subjective (SCD). <h3>Methods</h3> We classified 693 participants SCD (60 ± 9 years, 41% women, Mini-Mental State Examination score 28 2) from Amsterdam Dementia Cohort Subjective Cognitive Impairment (SCIENCe) project according to model, as determined by amyloid PET or CSF β-amyloid (A), p-tau (T), MRI-based medial...
We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, cross-sectionally participant characteristics, and evaluate SCD-plus criteria. The SCIENCe is a prospective cohort of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection optional amyloid positron emission tomography scan, with annual follow-up. primary outcome measure clinical progression. Cross-sectional evaluation first 151...
Gitelman9s syndrome is a congenital renal tubular defect which affects the apical membrane of distal convoluted tubule system. The characterised by hypokalaemia, hypomagnesaemia, metabolic alkalosis and hypocalcuria. There are only few cases describing impact on pregnancy foetus. Although most pregnancies have favourable outcomes, fetal demise has been reported in third trimester. We report successful outcome patient with who continued amiloride to optimise potassium magnesium levels review...
We examined the relationships between amyloid-β PET and concurrent longitudinal cognitive performance in 107 cognitively normal individuals with subjective decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 1). All underwent 90-minute dynamic [18F]florbetapir scanning neuropsychological tests a mean follow-up of 3.4 3.0 years. Receptor parametric mapping was used to calculate binding potential (BPND), we performed linear mixed models assess global BPND...
Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured quantitative PET, may help to explain the phenotype SCD. The aim this study was investigate whether load both self- and informant-reported complaints memory deficit awareness in individuals Methods: We included 106 SCD patients (mean ± SD age: 64 8, 45%F) 90 min dynamic [18F]florbetapir PET scans. used following...
Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim this study was examine vivo associations between pathology, quantified with [18F]flortaucipir PET regions corresponding stages, and atrophy across Alzheimer's disease (AD) spectrum.We included 100 subjects, including 58 amyloid-β positive patients mild cognitive impairment (MCI, n = 6) or AD...
Abstract Purpose We aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), their relationship with cognition in Alzheimer’s disease (AD), by using a single dynamic [ 18 F]flortaucipir positron emission tomography (PET) scan. Methods Seventy-one subjects AD (66 ± 8 years, mini-mental state examination (MMSE) 23 4) underwent 130-min PET Cognitive assessment consisted of composite scores four cognitive domains. For rCBF, receptor parametric mapping...
Abstract Purpose In vivo Alzheimer’s disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated (p-tau) and [ 18 F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with PET the of both cognition atrophy. Methods We included 78 amyloid positive cognitively impaired patients (clinical diagnoses mild cognitive impairment (MCI, n = 8) AD dementia ( 45) 25 normal subjects subjective decline (SCD) (40%...
To assess the [18F]flortaucipir binding distribution across MAPT mutations in presymptomatic and symptomatic carriers.We compared regional potential (BPND) derived from a 130-minute dynamic PET scan 9 (pre)symptomatic mutation carriers (4 with P301L [1 symptomatic], 2 R406W 1 L315R, S320F, G272V carrier) 30 cognitively normal controls 52 patients Alzheimer disease.[18F]Flortaucipir BPND images showed overall highest carriers. This was most pronounced carrier whom tau exceeded control range...
Accumulation of amyloid beta can be visualized using [ 18 F]florbetapir positron emission tomography. The aim this study was to identify the optimal model for quantifying uptake and assess test–retest reliability corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 3) eight controls 63 4 MMSE: 30 0) were included. Ninety-minute dynamic tomography scans, together with arterial blood sampling, acquired immediately...
[18F]Flortaucipir is a PET tau tracer used to visualize binding in Alzheimer's disease (AD) vivo. The present study evaluated the performance of several methods obtain parametric images [18F]flortaucipir. One hundred and thirty minutes dynamic scans were performed 10 AD patients controls. Parametric generated using different linearization basis function approaches. Regional potential (BPND) volume distribution (VT) values obtained from compared with corresponding derived reversible...
The aim of this study was to investigate the test–retest (TRT) repeatability various parametric quantification methods for [ 18 F]Flortaucipir positron emission tomography (PET). We included eight subjects with dementia or mild cognitive impairment due Alzheimer’s disease and six cognitively normal subjects. All underwent two 130-min dynamic PET scans within 3 ± 1 weeks. Data were analyzed using reference region models receptor mapping (RPM), simplified tissue method 2 (SRTM2) logan...
Early-onset Alzheimer's disease (EOAD) and late-onset (LOAD) differ in neuropathological burden type of cognitive deficits. Assessing tau pathology relative cerebral blood flow (rCBF) measured with [18F]flortaucipir PET relation to cognition may help explain these differences between EOAD LOAD.Seventy-nine amyloid-positive individuals a clinical diagnosis AD (EOAD: n = 35, age-at-PET 59 ± 5, MMSE 23 4; LOAD: 44, 71 4) underwent 130-min dynamic scan extensive neuropsychological assessment. We...
Abstract Purpose Visual reading of 18 F-florbetapir positron emission tomography (PET) scans is used in the diagnostic process patients with cognitive disorders for assessment amyloid-ß (Aß) depositions. However, this can be time-consuming, and difficult case borderline amyloid pathology. Computer-aided pattern recognition helpful but needs to validated. The aim work was develop, train, validate test a convolutional neural network (CNN) discriminating between Aß negative positive PET...
The role of cerebral blood flow (CBF) in the early stages Alzheimer's disease is complex and largely unknown. We investigated cross-sectional longitudinal associations between CBF, amyloid burden, cognition, cognitively normal individuals with subjective cognitive decline (SCD).We included 187 SCD from SCIENCe project (65 ± 8 years, 39% F, MMSE 29 1). Each underwent a dynamic (0-70 min) [18F]florbetapir PET T1-weighted MRI scan, enabling calculation mean binding potential (BPND; specific...
Off-target binding in the choroid plexus (CP) may cause spill-in of tau PET tracer [18F] flortaucipir into adjacent hippocampus region. The impact this on hippocampal uptake was assessed using a novel partial volume correction method (PVC). PVC performed 20 dynamic scans (10 probable AD and 10 controls). Volumes interest (VOIs) were defined for both CP. correlation between CP distribution (VT), with without PVC, determined. Both anatomically eroded VOIs used. For controls, VT significantly...
Alpha-synuclein often co-occurs with Alzheimer's disease (AD) pathology in Dementia Lewy Bodies (DLB). From a dynamic [18F]flortaucipir PET scan we derived measures of both tau binding and relative cerebral blood flow (rCBF). We tested whether regional or rCBF differed between DLB patients AD controls examined their association clinical characteristics DLB. Eighteen probable DLB, 65 50 underwent 130-minute scan. positive biomarkers for based on cerebrospinal fluid amyloid were considered as...
Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration 130 min. The current study assessed effect shorter [18F]flortaucipir on its quantitative accuracy.Two cohorts with Alzheimer's disease (AD) patients and healthy controls (HC) were included. All subjects underwent a 130-min PET consisting two parts (0-60/80-130 min) post-injection....
A lumbar puncture is performed to obtain cerebral spinal fluid. It implemented in the clinic on a routine basis aid diagnosis of neurologic diseases, such as dementia. This video will show procedure routinely VUmc Alzheimer Center.
Accumulation of amyloid beta (Aβ) is one the pathological hallmarks Alzheimer’s disease (AD), which can be visualized using [ 18 F]florbetapir positron emission tomography (PET). The aim this study was to evaluate various parametric methods and assess their test-retest (TRT) reliability. Two 90 min dynamic PET scans, including arterial sampling, were acquired ( n = 8 AD patient, controls). following used; (reference:cerebellum); Logan spectral analysis (SA), receptor mapping (RPM),...
Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas nondisplaceable binding potential (BP<sub>ND</sub>) are not. For <sup>18</sup>F-flortaucipir PET, the sensitivity of for flow is currently unknown. Therefore, we compared semiquantitative parameters longitudinal scans assessed their vulnerability to...
Off-target [18F]flortaucipir (tau) PET binding in the choroid plexus causes spill-in into nearby hippocampus, which may influence correlation between and measures of cognition. Previously, we showed that partial volume correction (combination Van Cittert iterative deconvolution HYPR denoising; PVC HDH) manually eroding hippocampus resulted a significant decrease spill-in. In this study, compared three different approaches for quantification hippocampal signal using semi-automated technique,...
Abstract Purpose To determine thresholds for amyloid beta pathology and evaluate associations with longitudinal memory performance the aim to identify a grey zone of early accumulation investigate its clinical relevance. Methods We included 162 cognitively normal participants subjective cognitive decline from SCIENCe cohort (64 ± 8 years, 38% F, MMSE 29 1). Each underwent dynamic [ 18 F] florbetapir PET scan, T1-weighted MRI scan assessments (RAVLT delayed recall, n = 655 examinations)....