A5000907784- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Cardiac Imaging and Diagnostics
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Alzheimer's disease research and treatments
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- S100 Proteins and Annexins
- Blood properties and coagulation
- Ion channel regulation and function
- Gastric Cancer Management and Outcomes
Amsterdam Neuroscience
2016-2025
Vrije Universiteit Amsterdam
2006-2025
Amsterdam University Medical Centers
2019-2025
Dutch Cancer Society
2023-2025
Cancer Center Amsterdam
2020-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014-2024
Boehringer Ingelheim (Germany)
2024
CellSight Technologies (United States)
2024
Boehringer Ingelheim (Australia)
2024
The Netherlands Cancer Institute
2020
A major pathological hallmark of Alzheimer's disease is accumulation amyloid-β in senile plaques the brain. Evidence accumulating that decreased clearance from brain may lead to these elevated levels. One pathways transport across blood–brain barrier via efflux transporters. P-glycoprotein, an pump highly expressed at endothelial cells barrier, has been shown amyloid-β. P-glycoprotein function can be assessed vivo using (R)-[11C]verapamil and positron emission tomography. The aim this study...
P-glycoprotein (Pgp) is an efflux transporter involved in transport of several compounds across the blood-brain barrier (BBB). Loss Pgp function with increasing age may be development age-related disorders, but this differ between males and females. can quantified vivo using (R)-[(11)C]verapamil positron emission tomography. The purpose study was to assess global regional effects both gender on BBB function.Thirty-five healthy men women three different groups were included. Sixty minutes...
// Catharina Willemien Menke-van der Houven van Oordt 1, * , Elske C. Gootjes Marc Huisman 2 Danielle J. Vugts Chantal Roth 1 Anne Marije Luik Emma R. Mulder Robert Schuit Ronald Boellaard Otto S. Hoekstra Guus AMS Dongen Henk M.W. Verheul Dept of Medical Oncology, VU University Center, Amsterdam, The Netherlands Radiology and Nuclear Medicine, These authors have contributed equally to this work Correspondence to: Verheul, e-mail: h.verheul@vumc.nl Keywords: immunoPET, cetuximab, colorectal...
To evaluate whether, in patients with non-small cell lung carcinoma (NSCLC), tumor uptake of [(11)C]erlotinib can be quantified and imaged using positron emission tomography to assess whether the level tracer corresponds presence activating EGF receptor (EGFR) mutations.Ten NSCLCs, five an EGFR exon 19 deletion, without were scanned twice (test retest) on same day interval at least 4 hours. Each scanning procedure included a low-dose computed tomographic scan, 10-minute dynamic [(15)O]H(2)O...
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([ 18 F] DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was develop a plasma input tracer kinetic model for quantification [ F]DPA-714 binding in healthy subjects and Alzheimer's disease (AD) patients, provide preliminary assessment whether there is disease-related signal. Ten AD patients six underwent...
The mechanism of synaptic loss in Alzheimer's disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional pathology ([18F]flortaucipir PET), density (synaptic vesicle 2A [11C]UCB-J PET) function disease.Seven amyloid-positive subjects from the Amsterdam Dementia Cohort underwent dynamic 130-min [18F]flortaucipir PET, 60-min PET...
Due to the restricted expression of α(v)β(3) in tumours, is considered a suitable receptor for tumour targeting. In this study α(v)β(3)-binding characteristics (68)Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined compared with their (111)In-labelled counterparts.A monomeric (E-c(RGDfK)), (E-[c(RGDfK)](2)) (E{E[c(RGDfK)](2)}(2)) peptide synthesised, conjugated DOTA radiolabelled (68)Ga. vitro competitive binding assay. vivo α(v)β(3)-targeting compounds assessed mice...
Neuroinflammation, in particular activation of microglia, is thought to play an important role the progression neurodegenerative diseases. In activated purinergic P2X 7 receptor upregulated. A‐740003, a highly affine and selective antagonist, promising candidate for development radiotracer imaging neuroinflammation by positron emission tomography. For this purpose, [ 11 C]A‐740003 was synthesised evaluated vivo with respect both tracer metabolism biodistribution. plasma, moderate metabolic...
Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such neuroinflammation, vivo. The second generation radioligand [18F]DPA714 binds with high affinity to 18-kDa translocator-protein (TSPO), which is mainly expressed on activated microglia. aim this proof concept study was evaluate vivo marker neuroinflammation primary and secondary...
The aim of this work was to quantify the uptake <sup>18</sup>F-BMS-986192, a programmed cell death ligand 1 (PD-L1) adnectin PET tracer, in patients with non–small lung cancer. To end, plasma input kinetic modeling dynamic tumor data online arterial blood sampling performed. In addition, accuracy simplified metrics such as SUV investigated. <b>Methods:</b> Data from study <sup>18</sup>F-BMS-986192 advanced-stage cancer eligible for nivolumab treatment were used if scan available and lesions...
Abstract The P2X 7 receptor plays a significant role in microglial activation, and as potential drug target, the is also an interesting target positron emission tomography. current study aimed at development evaluation of potent tracer targeting receptor, to which end four adamantanyl benzamide analogues with high affinity for human were labelled carbon-11. All could be obtained excellent radiochemical yield purity molar activity, all entered rat brain. [ 11 C]SMW139 showed highest metabolic...
Abstract Purpose The novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. purposes of this first in-man study were characterise pharmacokinetics in patients active relapsing remitting multiple sclerosis (RRMS) and healthy controls (HC) evaluate its potential identify vivo neuroinflammation RRMS. Methods Five RRMS 5 age-matched HC underwent 90-min dynamic scans, online continuous manual arterial sampling generate a...
P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as Alzheimer's disease, and drug resistant epilepsy. Positron emission tomography using the Pgp substrate tracer (R)-[11C]verapamil enables vivo quantification of function at human blood-brain barrier. Knowledge test-retest variability is important for assessing changes over time or after treatment with disease-modifying drugs. The purpose this study was to assess reproducibility several kinetic models used...
P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from brain and, as such, might be pathogenesis Alzheimer's disease. encoded by highly polymorphic ABCB1 gene. Single-nucleotide polymorphisms gene have been associated with altered expression and function. function at can quantified vivo using substrate tracer (R)-[11C]verapamil positron emission tomography (PET). The purpose this study was to assess effects C1236T, G2677T/A C3435T...
Summary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology long COVID is unknown. Here we present in-vivo evidence widespread neuroinflammation in COVID, using quantitative assessment, [ 18 F]DPA-714 PET, two patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both with had increases binding throughout the brain....
[(18)F]VM4-037 was recently developed as a positron emission tomography (PET) tracer for the detection of carbonic anhydrase IX (CAIX), tumor-specific protein upregulated under hypoxic conditions. In this study, accumulation determined in two CAIX-expressing preclinical human tumor models.U373 and HT29 tumor-bearing animals were injected with underwent microPET imaging up to 4 h post-injection (p.i.). Biodistribution throughout different organs assessed at 2 p.i. using gamma...
Radiolabeled prostate-specific membrane antigen (PSMA) PET has demonstrated promising results for prostate cancer (PCa) imaging. Quantification of PSMA radiotracer uptake is desired as it enables reliable interpretation images, use an imaging biomarker tumor characterization, and evaluation treatment effects. The aim this study was to perform a full pharmacokinetic analysis 2-(3-(1-carboxy-5-[(6-<sup>18</sup>F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid...