A5017533173- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Nonlinear Dynamics and Pattern Formation
- Advanced MRI Techniques and Applications
Amsterdam Neuroscience
2020-2023
Vrije Universiteit Amsterdam
2020-2023
Amsterdam University Medical Centers
2018-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2021
Abstract Background Although numerous electroencephalogram (EEG) studies have described differences in functional connectivity Alzheimer’s disease (AD) compared to healthy subjects, there is no general consensus on the methodology of estimating AD. Inconsistent results are reported due multiple methodological factors such as diagnostic criteria, small sample sizes and use measures sensitive volume conduction. We aimed investigate reproducibility disease-associated effects by commonly used...
The mechanism of synaptic loss in Alzheimer's disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional pathology ([18F]flortaucipir PET), density (synaptic vesicle 2A [11C]UCB-J PET) function disease.Seven amyloid-positive subjects from the Amsterdam Dementia Cohort underwent dynamic 130-min [18F]flortaucipir PET, 60-min PET...
Analysis of functional brain networks in Alzheimer's disease (AD) has been hampered by a lack reproducible, yet valid metrics connectivity (FC). This study aimed to assess both the sensitivity and reproducibility corrected amplitude envelope correlation (AEC-c) phase lag index (PLI), two FC that are insensitive effects volume conduction field spread, separate cohorts patients with dementia due AD versus healthy elderly controls.Subjects clinical diagnosis biomarker proof, control group...
Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between regions interact strongly (functional connectivity); pattern of anatomical connections (structural or simple diffusion. Using magnetoencephalography (MEG), we investigated which pathways influence protein by modelling propagation process using an epidemic model. We compared modelled depositions...
Background: Neurophysiological measures of brain function, such as magnetoencephalography (MEG), are widely used in clinical neurology and have strong relations with cognitive impairment dementia but still underdeveloped multiple sclerosis (MS). Objectives: To demonstrate the value clinically applicable MEG-measures evaluating MS. Methods: In eyes-closed resting-state, MEG data 83 MS patients 34 healthy controls (HCs) peak frequencies relative power six canonical frequency bands for 78...
Abstract Introduction We report the routine application of magnetoencephalography (MEG) in a memory clinic, and its value discrimination patients with Alzheimer's disease (AD) dementia from controls. Methods Three hundred sixty‐six visiting our clinic underwent MEG recording. Source‐reconstructed data were visually assessed evaluated context clinical findings other diagnostic markers. analyzed accuracy spectral measures individual AD (n = 40) subjective cognitive decline (SCD) using random...
Background: In Alzheimer’s disease (AD), oscillatory activity of the human brain slows down. However, slowing varies between individuals, particularly in prodromal AD. Cortical changes have shown suboptimal accuracy as diagnostic markers. We speculated that focusing on hippocampus might prove more successful, using magnetoencephalography (MEG) for capturing subcortical activity. Objective: explored MEG-based detection hippocampal abnormalities AD patients. Methods: acquired resting-state MEG...
A common problem in resting-state neuroimaging studies is that subjects become drowsy or fall asleep. Although this could drastically affect neurophysiological measurements, such as magnetoencephalography (MEG), its specific impact remains understudied. We aimed to systematically investigate how often drowsiness present during MEG recordings, and the state changes alter quantitative estimates of oscillatory activity, functional connectivity, network topology.About 8-min recordings 19 healthy...
Accurate identification of the underlying cause(s) cognitive decline and dementia is challenging due to significant symptomatic overlap between subtypes. This study presents a multi-class classification framework for subjects with subjective decline, mild impairment, Alzheimer's disease, Lewy bodies, fronto-temporal psychiatric illness, trained on source-localized resting-state magnetoencephalography data. Diagnostic profiles, describing probability estimates each 6 diagnoses, were assigned...
Abstract Background Recent studies in Alzheimer’s disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved this process: spreading between regions interact strongly (functionally connected); pattern of anatomical connections (structural connectivity); or simple diffusion to spatially adjacent (Euclidean distance (EC)). We investigated by modelling tau‐spreading process on these different networks, and compared...
Abstract Background Early Alzheimer’s disease (AD) is characterized by pathological hippocampal hyperactivity 1,2 . Non‐invasive detection of relevant for diagnostic and therapeutic purposes, but no reliable method available. We tested magneto‐encephalographical (MEG) activity, hypothesizing that in amyloid‐positive MCI patients resting‐state activity would be higher than both controls AD patients. Method used MEG data from 18 mild/moderate patients, (CSF) amnestic persons with subjective...
Abstract Background Brain network studies have revealed that highly connected ‘hub’ regions are particularly vulnerable to Alzheimer’s disease (AD) pathology. Additionally, the ‘‘transneuronal spread” hypothesis proposes a toxic agent (tau) propagates along shortest paths through functionally neurons, driven by aberrant neuronal activity. We investigate whether characteristics as determined using magnetoencephalography (MEG) correlated tau pathology in different stages of AD. Method analysed...
Abstract Background Recent fMRI studies have provided evidence that tau proteins may spread through the brain in stereotypical patterns following functional connections. However, is an indirect measure of neuronal activity, and has limited temporal resolution, contrary to magnetoencephalography(MEG). We aimed investigate whether changes connectivity network organization mirror regional retention (preclinical) Alzheimer’s disease(AD), using MEG in‐vivo 18 F‐flortaucipir (tau) PET. Methods...
Abstract Background The mechanisms contributing to synaptic loss in Alzheimer’s disease (AD) are poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) magnetoencephalography (MEG) study, we therefore investigated associations between ([ 18 F]flortaucipir PET), density (synaptic vesicle 2A [ 11 C]UCB‐J PET) function AD. Method Seven amyloid‐positive AD subjects (age 64.3±8.2; 3/7 female; MMSE 24.1±1.8) were included from the Amsterdam...