A5052877887- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Amyotrophic Lateral Sclerosis Research
- Business Strategy and Innovation
- Innovation and Knowledge Management
- Cholinesterase and Neurodegenerative Diseases
- Genetic Neurodegenerative Diseases
- Mental Health Research Topics
- Optical Imaging and Spectroscopy Techniques
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Epilepsy research and treatment
Amsterdam University Medical Centers
2021-2025
Vrije Universiteit Amsterdam
2021-2025
Amsterdam Neuroscience
2015-2022
University of Amsterdam
2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2016
Zuyd University of Applied Sciences
2012
EEG studies have shown that patients with Alzheimer's disease (AD) weaker functional connectivity than controls, especially in higher frequency bands. Furthermore, active regions seem more prone to AD pathology. How is affected subgroups of severity and how network hubs (highly connected brain areas) change not known. We compared different controls terms connections, hub strength location.
Although frequency-specific network analyses have shown that functional brain networks are altered in patients with Alzheimer's disease, the relationships between these alterations remain largely unknown. Multiplex analysis is a novel approach to study complex systems consisting of subsystems different types connectivity patterns. In this study, we used magnetoencephalography integrate five frequency-band specific multiplex framework. Previous structural and studies consistently hub areas...
Pathology in Alzheimer's disease (AD) starts the entorhinal cortex and hippocampus. Because of their deep location, activity from these areas is difficult to record with conventional electro- or magnetoencephalography (EEG/MEG). The purpose this study was explore hippocampal AD patients healthy controls using "virtual MEG electrodes". We used resting-state recordings 27 early onset [age 60.6 ± 5.4, 12 females, mini-mental state examination (MMSE) range: 19-28] 26 cognitively age-...
In a recent magnetoencephalography (MEG) study, we found posterior-to-anterior information flow over the cortex in higher frequency bands healthy subjects, with reversed pattern theta band. A disruption of may underlie clinical symptoms Alzheimer's disease (AD). AD, highly connected regions (hubs) posterior areas are mostly disrupted. We therefore hypothesized that AD from these hub would be disturbed. used resting-state MEG recordings 27 early-onset patients and 26 controls. Using...
Abstract Amyotrophic lateral sclerosis (ALS) with only motor impairment (ALS-pure motor) and the behavioural variant of frontotemporal dementia (bvFTD) are hypothesized to represent extreme ends a disease-spectrum which encompasses ALS cognitive/behavioural (ALSci/bi). In this longitudinal magnetoencephalography (MEG) study, we investigated changes in brain network topology ALSci/bi over time as compared ALS-pure bvFTD patients. Resting-state MEG was recorded (n=9), (n=16) at baseline...
ABSTRACT This article contributes to research on dynamic managerial capabilities, which examines impact firms' strategic change. Specifically, we study the role of social capital—a key underpinning capabilities—in organizations' We propose a temporally contingent account that elucidates how fitness capabilities unfolds across life cycle stages and varying degrees change pressures. start by testing our theoretical model using data 20,593 individuals in 5522 new ventures over period 5 years. A...
Subjects with mild cognitive impairment (MCI) have an increased risk of developing Alzheimer's disease (AD), and their functional brain networks are presumably already altered. To test this hypothesis, we compared magnetoencephalography (MEG) eyes-closed resting-state recordings from 29 MCI subjects healthy elderly in the present exploratory study. Functional connectivity different frequency bands was assessed phase lag index (PLI) source space. Normalized weighted clustering coefficient...
The objective of this study was to examine if patterns resting-state brain activity and functional connectivity in cortical subcortical regions patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those behavioural variant frontotemporal dementia (bvFTD). In a cross-sectional design, eyes-closed magnetoencephalography (MEG) data 34 ALS patients, 18 bvFTD age- gender-matched healthy controls (HCs) were projected source-space using an atlas-based beamformer. Group...
Accurate identification of the underlying cause(s) cognitive decline and dementia is challenging due to significant symptomatic overlap between subtypes. This study presents a multi-class classification framework for subjects with subjective decline, mild impairment, Alzheimer's disease, Lewy bodies, fronto-temporal psychiatric illness, trained on source-localized resting-state magnetoencephalography data. Diagnostic profiles, describing probability estimates each 6 diagnoses, were assigned...
Neurophysiological changes in oscillatory brain activity Alzheimer’s disease (AD) are well described. Brain oscillations traditionally subdivided into different frequency bands. Previous studies found slowing of AD. However, when only studying the bands independently, one does not take account correlations between The relationship can be captured by cross-frequency coupling (CFC). We hypothesize to find CFC disruptions disease-related areas recorded resting-state Magnetoencephalography (MEG)...
Former electroencephalography (EEG) studies have shown that posterior brain regions of patients with Alzheimer's disease (AD) weaker functional connectivity than controls. Analyses these networks a central role within the network. How severity influences areas network, is insufficiently known. We studied resting-state EEG 318 AD (categorized into three subgroups based on severity) and 133 age-matched Functional between channels was estimated Phase Lag Index (PLI). From PLI-based matrix,...
The amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum also encompasses ALS with cognitive/behavioural impairment (ALSci/bi). In this longitudinal study, we used magnetoencephalography (MEG) to investigate the changes in brain network topology of ALSci/bi over time as compared extreme ends ALS-bvFTD (ALS-pure motor and behavioural variant FTD (bvFTD).Reference Minimum Spanning Trees (MSTs) were computed for either ALS-pure or bvFTD, against which networks...