A5031897532- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Hormonal and reproductive studies
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Advanced MRI Techniques and Applications
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Glutathione Transferases and Polymorphisms
- Advanced Radiotherapy Techniques
- Marine Biology and Environmental Chemistry
- Ovarian cancer diagnosis and treatment
- Cardiovascular Disease and Adiposity
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Neurological Disorders and Treatments
Amsterdam University Medical Centers
2019-2024
Vrije Universiteit Amsterdam
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2018
Medical University of Vienna
2014
University of Vienna
2000
Johannes Gutenberg University Mainz
1987-1992
West Virginia University
1987
To assess (1) the repeatability and (2) impact of reconstruction methods delineation on 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies. Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using point spread function (PSF) complying with European Association for Nuclear Medicine (EANM) guidelines tumor PET imaging....
An acute limbic-cerebellar syndrome was seen in six industrial workers who inhaled trimethyltin (TMT). Clinical features included hearing loss, disorientation, confabulation, amnesia, aggressiveness, hyperphagia, disturbed sexual behavior, complex partial and tonic-clonic seizures, nystagmus, ataxia, mild sensory neuropathy. Severity paralleled maximal urinary organotin levels. One patient died two remained seriously disabled.
Change in (18)F-FDG uptake may predict response to anticancer treatment. The PERCIST suggest a threshold of 30% change SUV define partial and progressive disease. Evidence underlying these thresholds consists mixed stand-alone PET PET/CT data with variable intervals no consensus on the number lesions be assessed. Additionally, there is increasing interest alternative measures such as metabolically active tumor volume total lesion glycolysis (TLG). aim this study was comprehensively...
Radiolabeled prostate-specific membrane antigen (PSMA) PET has demonstrated promising results for prostate cancer (PCa) imaging. Quantification of PSMA radiotracer uptake is desired as it enables reliable interpretation images, use an imaging biomarker tumor characterization, and evaluation treatment effects. The aim this study was to perform a full pharmacokinetic analysis 2-(3-(1-carboxy-5-[(6-<sup>18</sup>F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid...
Total metabolic active tumour volume (TMATV) and total burden (TTB) are increasingly studied as prognostic predictive factors in non-small cell lung cancer (NSCLC) patients. In this study, we investigated the repeatability of TMATV TTB function uptake interval, positron emission tomography/computed tomography (PET/CT) image reconstruction settings, lesion delineation method. We used six methods, four direct PET image-derived delineations two based on a majority vote approach, i.e....
Accurate quantification of tracer uptake in small tumors using PET is hampered by the partial-volume effect as well method volume-of-interest (VOI) delineation. This study aimed to investigate correction (PVC) combined with several VOI methods on accuracy and precision quantitative PET.Four image-based PVC resolution modeling (applied PVC) were used combination common methods. Performance was evaluated simulations, phantom experiments, clinical repeatability studies. Simulations based a...
There is increased interest in various new quantitative uptake metrics beyond SUV oncologic PET/CT studies. The purpose of this study was to investigate the variability and test–retest ratio (TRT) metabolically active tumor volume (MATV) measurements several other non–small cell lung cancer using <sup>18</sup>F-FDG with different segmentation methods, user interactions, intervals, reconstruction protocols. <b>Methods:</b> Ten patients advanced received 2 series whole-body scans at 60 min...
Partial-volume effects generally result in an underestimation of tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume correction (PVC) accurate quantification. However, investigation PVC dynamic oncological PET studies to date is scarce. The aim this study was investigate PVC's impact kinetic parameter estimation from acquisitions and subsequent validation simplified semi-quantitative metrics. Ten patients with EGFR-mutated non-small cell lung cancer underwent...
<sup>18</sup>F-fluorodihydrotestosterone (<sup>18</sup>F-FDHT) PET/CT potentially provides a noninvasive method for assessment of androgen receptor expression in patients with metastatic castration-resistant prostate cancer (mCRPC). The objective this study was to assess simplified methods quantifying <sup>18</sup>F-FDHT uptake mCRPC and effects tumor perfusion on these metrics. <b>Methods:</b> Seventeen were included prospective observational multicenter study. Test retest 30-min dynamic...
Whole body [18F]-fluorodihydrotestosterone positron emission tomography ([18F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic predictive biomarker in metastatic castration-resistant cancer (mCRPC). To optimize [18F]FDHT PET-CT for diagnostic response assessment purposes, we assessed how count statistics reconstruction protocol affect its accuracy, repeatability, lesion detectability. scans were acquired on an analogue two consecutive days 14 mCRPC...
PET radiomics applied to oncology allow the measurement of intratumoral heterogeneity. This quantification can be affected by image protocols; hence, there is an increased interest in understanding how radiomic expression on images different imaging conditions. To address that interest, this study explored features are changes <sup>18</sup>F-FDG uptake time, reconstruction, lesion delineation, and binning settings. <b>Methods:</b> Ten non–small cell lung cancer patients underwent 2...
[18F]-fluorothymidine ([18F]-FLT) is a PET-tracer enabling in-vivo visualization and quantification of tumor cell proliferation. For qualitative quantitative analysis, adequate knowledge normal tissue uptake indispensable. This study aimed to quantitatively investigate baseline tracer blood pool, lung, liver bone marrow their precision, assess the longitudinal effect systemic treatment on biodistribution. 18F–FLT-PET(/CT) scans (dynamic or static) 90 treatment-naïve oncological patients were...
3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [18F]FLT a perfusion-independent PET tracer, by gaining insight intra-tumoural relationship between uptake and perfusion non-small cell lung cancer (NSCLC) patients undergoing treatment tyrosine kinase inhibitor (TKI). Six metastatic NSCLC, having activating epidermal growth factor...
The objective of this study was to validate several parametric methods for quantification 3′-deoxy-3′-<sup>18</sup>F-fluorothymidine (<sup>18</sup>F-FLT) PET in advanced-stage non–small cell lung carcinoma (NSCLC) patients with an activating epidermal growth factor receptor mutation who were treated gefitinib or erlotinib. Furthermore, we evaluated the impact noise on accuracy and precision analyses dynamic <sup>18</sup>F-FLT PET/CT assess robustness these methods. <b>Methods<i>:</i></b> Ten...
Aims Colorectal polyp size is important for risk stratification and clinical decision-making regarding polypectomy technique surveillance intervals. However, measurement known to be prone inter-observer variability a standardized method lacking. Recently, virtual scale (VS) function has been developed that facilitates through the projection of on monitor screen during live endoscopy. This study aimed compare VS measurements other methods in terms systematic differences. Moreover, feasibility...