A5061935915- Chemical Synthesis and Analysis
- Supramolecular Chemistry and Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthetic Organic Chemistry Methods
- Adenosine and Purinergic Signaling
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Radiopharmaceutical Chemistry and Applications
- RNA Interference and Gene Delivery
- Inorganic and Organometallic Chemistry
- Cancer Genomics and Diagnostics
- Crystallography and molecular interactions
- Drug Transport and Resistance Mechanisms
- Brain Metastases and Treatment
- Porphyrin and Phthalocyanine Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Organometallic Complex Synthesis and Catalysis
- Prion Diseases and Protein Misfolding
- Cyclopropane Reaction Mechanisms
- Advanced Physical and Chemical Molecular Interactions
- Various Chemistry Research Topics
- Autophagy in Disease and Therapy
The University of Sydney
2019-2025
University of Manchester
2015-2020
University of Bristol
2016
Three strands ironed closely together It is not uncommon when braiding hair or bread to intertwine three different strands. At the molecular level, however, synthetic knots have thus far been restricted architectures accessible from two-strand braids. Danon et al. used iron ion coordination guide organic ligand form a knot geometry with eight separate crossings. Science , this issue p. 159
A molecular Solomon link was synthesized through the assembly of an interwoven grid consisting four bis(benzimidazolepyridyl)benzthiazolo[5,4-d]thiazole ligands and zinc(II), iron(II), or cobalt(II) cations, followed by ring-closing olefin metathesis. NMR spectroscopy, mass spectrometry, X-ray crystallography confirmed doubly interlocked topology, subsequent demetalation afforded wholly organic link. The synthesis, in which each metal ion defines crossing point two ligand strands, suggests...
Post-translational modifications (PTMs) of proteins are becoming the focus intense research due to their implications in a broad spectrum neurodegenerative diseases. Various PTMs have been identified alter toxic profiles which play critical roles disease etiology. In Alzheimer's (AD), dysregulated phosphorylation is reported promote pathogenic processing microtubule-associated tau protein. Among PTMs, enzymatic addition N-acetyl-d-glucosamine (GlcNAc) residues Ser/Thr deliver protective...
Abstract Reproducible laboratory research relies on correctly identified reagents. We have previously described gene papers with wrongly nucleotide sequence(s), including studying miR‐145 . Manually verifying reagent identities in 36 recent found that 56% and 17% of misidentified sequences cell lines, respectively. also 5 line identifiers 18 published elsewhere, did not represent indexed human lines. These 23 were as non‐verifiable (NV), their unclear. Studying 420 mentioned 8 NV...
The translocator protein (TSPO) is an 18 kDa on the outer mitochondrial membrane. It has gained significant interest in recent years for its potential as a therapeutic target and imaging biomarker, particularly neuroinflammation, cancer, central nervous system disorders (CNS). Clinical translation of ligands been complicated by presence common single nucleotide polymorphism (A147T TSPO), at which many disclosed TSPO lose affinity. One exception first-generation ligand PK 11195, however, this...
[4]Rotaxanes featuring three axles threaded through a single ring have been prepared active metal template synthesis. Nickel-catalyzed sp3–sp3 homocouplings of alkyl bromide "half-threads" 37- and 38-membered 2,2′:6′,2″-terpyridyl macrocycles generate triply [4]rotaxanes in up to 11% yield. An analogous 39-membered macrocycle produced no rotaxane products under similar conditions. The constitutions the were determined by NMR spectroscopy mass spectrometry. Doubly [3]rotaxanes also obtained...
Abstract A molecular link (a six crossing, doubly interlocked, [2]catenane with twisted rings) and a 3 1 #3 granny knot composite made up of two trefoil tangles the same handedness) were constructed by ring‐closing olefin metathesis an iron(II)‐coordinated 2×2 interwoven grid. The connections directed pendant phenyl groups to be between proximal ligand ends on faces was separated from topoisomeric recycling size‐exclusion chromatography. identity each topoisomer determined tandem mass...
The α-helical coiled coil is one of the best-studied protein–protein interaction motifs. As a result, sequence-to-structure relationships are available for prediction natural coiled-coil sequences and de novo design new ones. However, coils adopt wide range oligomeric states topologies, our understanding specification these discrimination between them remains incomplete. Gaps in knowledge assume more importance as used increasingly to construct biomimetic systems higher complexity; this,...
Abstract A molecular Solomon link was synthesized through the assembly of an interwoven grid consisting four bis(benzimidazolepyridyl)benzthiazolo[5,4‐d]thiazole ligands and zinc(II), iron(II), or cobalt(II) cations, followed by ring‐closing olefin metathesis. NMR spectroscopy, mass spectrometry, X‐ray crystallography confirmed doubly interlocked topology, subsequent demetalation afforded wholly organic link. The synthesis, in which each metal ion defines crossing point two ligand strands,...
Abstract Background P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for glial reactivity. [ 11 C]SMW139 is most recently developed radiotracer image receptor. The aim of this study was reactive glia in APP/PS1-21 transgenic (TG) mouse model Aβ deposition longitudinally using targeting and compare tracer uptake that 18 F]F-DPA TSPO at final time point. TG wild type (WT) mice underwent longitudinal vivo 5, 8, 11, 14 months, followed by scan...
The unique structural and physicochemical properties of adamantane its derivatives have attracted considerable attention in the field medicinal chemistry. Substituting phenyl rings for or has provided a promising strategy to introduce lipophilicity escape ‘flat land’ modern drug discovery. Additionally, three-dimensional structure facilitates precise positioning substituents allowing more effective exploration targets. Evidently, we seen an increased use pharmaceutically relevant molecules....
Abstract A molecular link (a six crossing, doubly interlocked, [2]catenane with twisted rings) and a 3 1 #3 granny knot composite made up of two trefoil tangles the same handedness) were constructed by ring‐closing olefin metathesis an iron(II)‐coordinated 2×2 interwoven grid. The connections directed pendant phenyl groups to be between proximal ligand ends on faces was separated from topoisomeric recycling size‐exclusion chromatography. identity each topoisomer determined tandem mass...
Despite their acknowledged significance in the inflammatory signalling cascade across a range of disease states, P2X7R antagonists have not yet proven to be effective clinical trials. In this study, we present findings on P2X7 receptor that are based core adamantyl-cyanoguanidine-quinoline lead. To investigate specific features cyanoguanidine moiety influence compound potency carried out structure-activity relationship (SAR) study. Compound was assessed using an vitro dye-uptake assay...