A5052910579- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Neuroscience of respiration and sleep
- Prenatal Substance Exposure Effects
- Mental Health Research Topics
- Mental Health and Psychiatry
- Psychedelics and Drug Studies
- Epilepsy research and treatment
- Forensic Toxicology and Drug Analysis
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Multisensory perception and integration
University Medical Center Utrecht
2016-2025
King's College London
2015-2025
Utrecht University
2008-2024
Heidelberg University
2010-2019
University Hospital Heidelberg
2010-2019
University Medical Center
2017
University Hospital and Clinics
2017
Trimbos Institute
2005-2010
Amsterdam UMC Location VUmc
2010
Cannabidiol (CBD) has antipsychotic effects in humans, but how these are mediated the brain remains unclear.To investigate neurocognitive mechanisms that underlie therapeutic of CBD psychosis.In this parallel-group, double-blind, placebo-controlled randomized clinical trial conducted at South London and Maudsley NHS Foundation Trust London, United Kingdom, 33 medication-naive participants high risk (CHR) psychosis 19 healthy control were studied. Data collected from July 2013 to October 2016...
Abstract Rationale Stress is a risk factor for psychosis and treatments which mitigate its harmful effects are needed. Cannabidiol (CBD) has antipsychotic anxiolytic effects. Objectives We investigated whether CBD would normalise the neuroendocrine anxiety responses to stress in clinical high (CHR) patients. Methods Thirty-two CHR patients 26 healthy controls (HC) took part Trier Social Test (TSST) their serum cortisol, associated with public speaking were estimated. Half of participants on...
Various psychiatric disorders such as major depression are associated with abnormalities in emotional processing. Evidence indicating involvement of the endocannabinoid system processing, and thus potentially related abnormalities, is increasing. In present study, we examined role processing stimuli a positive negative content healthy volunteers. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted placebo-controlled, cross-over design, investigating effects...
We recently reported that resting hippocampal, basal ganglia and midbrain perfusion is elevated in people at ultra high risk (UHR) for psychosis. The present study sought to replicate our previous finding an independent UHR cohort, examined the relationship between these regions, psychosis depression symptoms, traumatic experiences childhood. Pseudo-Continuous Arterial Spin Labelling (p-CASL) imaging was used measure cerebral blood flow (rCBF) 77 individuals 25 healthy volunteers a...
Preclinical and human data suggest that hippocampal dysfunction plays a critical role in the onset of psychosis. Neural hyperactivity hippocampus is thought to drive an increase subcortical dopamine function through glutamatergic projections striatum.To examine association between glutamate levels individuals at clinical high risk for psychosis their subsequent outcomes.This cross-sectional study 86 30 healthy control individuals, with mean follow-up 18.5 months, was conducted November 1,...
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Abstract Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, neurocognitive mechanisms underlying effect cannabidiol remain unclear. We investigated this in a double-blind, placebo-controlled, parallel-arm study. 33 antipsychotic-naïve subjects at clinical high risk for psychosis (CHR) randomised to 600 mg oral or placebo and compared them with 19 healthy controls. used monetary incentive delay task while participants underwent fMRI study reward...
Recently, two new ecstasy-like substances, methylone and mCPP, were found in street drugs the Netherlands by Drugs Information Monitoring System (DIMS). Methylone (3,4-methylenedioxymethcathinone) is main ingredient of a liquid designer drug that appeared on Dutch market, called 'Explosion'. mCPP (meta-chlorophenylpiperazine) substance often used as probe for serotonin function psychiatric research, has now been drugs, both tablets powders. well act monoaminergic systems, resembling MDMA...
Disturbed reward processing in humans has been associated with a number of disorders, such as depression, addiction, and attention-deficit hyperactivity disorder. The endocannabinoid (eCB) system implicated animals, but humans, the relation between eCB functioning is less clear.
Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well psychiatric disorders characterized by deficits, such schizophrenia. Executive function appears to be associated with both modulation active networks inhibition activity default mode network. In present study, we examined role focusing on brain network A pharmacological functional magnetic resonance imaging (fMRI) study was conducted a...