A5090018275- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Gambling Behavior and Treatments
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Adolescent and Pediatric Healthcare
- Advanced MRI Techniques and Applications
- Pharmaceutical studies and practices
- Neurological disorders and treatments
- Coaching Methods and Impact
- Medical Imaging Techniques and Applications
- Cognitive Functions and Memory
King's College London
2016-2025
London Borough of Southwark
2025
Bethlem Royal Hospital
2019-2024
South London and Maudsley NHS Foundation Trust
2018-2024
Cambridgeshire and Peterborough NHS Foundation Trust
2024
Qorvo (United States)
2022
Sheffield Hallam University
2021
National Institute for Health Research
2020
NIHR Maudsley Biomedical Research Centre
2020
Imperial College London
2008-2017
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal D2/D3 receptor availability has been reported in drug addiction, may constitute premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess PG, its association trait impulsivity. Males PG (n = 9) male healthy controls underwent [11C]-raclopride positron emission tomography imaging completed UPPS-P scale. There...
Abstract Cue reactivity is an established procedure in addictions research for examining the subjective experience and neural basis of craving. This experiment sought to quantify cue-related brain responses gambling disorder using personally tailored cues conjunction with craving, as well a comparison appetitive non-gambling stimuli. Participants ( n =19) attending treatment 19 controls viewed blocks gambling-related cues, neutral highly (food) images during functional magnetic resonance...
Pathological gambling is a psychiatric disorder and the first recognized behavioral addiction, with similarities to substance use disorders but without confounding effects of drug-related brain changes. Pathophysiology within opioid receptor system increasingly in dependence, higher mu-opioid (MOR) availability reported alcohol, cocaine opiate addiction. Impulsivity, risk factor across addictions, has also been found be associated MOR availability. The aim this study was characterize...
This study aimed to replicate a previous which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two PET scans, one before and 3 h amphetamine administration (0.5 mg/kg). Regional changes BPND from pre- post-amphetamine were assessed. The challenge led significant reductions putamen, thalamus, frontal lobe, nucleus...
Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major episodes, which contribute greatly to the high levels disability and mortality associated disorder. Despite importance depression, there are only small number recognised treatment options available. Consecutive failures can quickly exhaust these leading treatment-resistant depression (TRBD). Remarkably few studies have evaluated TRBD those available...
Cannabis use in adolescence is emerging as a risk factor for the development of psychosis. In animal studies, Δ9-tetrahydrocannabinol (THC), psychoactive component cannabis, modulates striatal dopaminergic neurotransmission. Alterations human function have also been reported both psychosis and stimulant use. We sought to examine whether dopamine D 2 /D 3 receptor availability was altered volunteers with history cannabis using database previously acquired [ 11 C]-raclopride positron emission...
Background: Options for ‘treatment-resistant bipolar depression’ (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option. Aims: To evaluate the clinical effectiveness and safety in management TRBD. Methods: A multi-centre randomised, double-blind controlled trial including participants ⩾18 years old with TRBD (failure to respond, tolerate or contraindication/patient refusal ⩾2 quetiapine, olanzapine, lamotrigine lurasidone) randomised 1:1 (max 2.5...
Introduction In England, eligible adults aged 40–74 years are invited to attend a face-to-face (F2F) NHS Health Check appointment every 5 years. A digital version of the was introduced by local authority as an alternative for those hesitant or less able F2F appointment. Objectives This qualitative study aimed understand service users’ (SUs) and healthcare professionals’ (HCPs) experiences opinions Checks (DHC), identify barriers facilitators DHC pathways, recommend potential improvements....
Background Elevated striatal dopamine synthesis capacity is thought to be fundamental the pathophysiology of schizophrenia and has also been reported in people at risk psychosis. It therefore unclear if hyperdopaminergia a vulnerability marker for schizophrenia, or state feature related psychosis itself. Relatives patients with are themselves increased developing condition. In this study we examined both members twin pairs discordant schizophrenia. Method vivo was using fluorine-18- l...