A5070858850- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Child Therapy and Development
- Electroconvulsive Therapy Studies
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Early Childhood Education and Development
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Face Recognition and Perception
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Psychotherapy Techniques and Applications
- Autism Spectrum Disorder Research
King's College London
2016-2025
Northwestern University
2018-2021
Northwestern University
2021
Dr. Kariadi Hospital
2020
The dopamine hypothesis suggests that abnormalities underlie psychosis, irrespective of diagnosis, implicating dysregulation in bipolar affective disorder and schizophrenia, line with the research domain criteria approach. However, this has not been directly examined individuals diagnosed psychosis.
We recently reported that resting hippocampal, basal ganglia and midbrain perfusion is elevated in people at ultra high risk (UHR) for psychosis. The present study sought to replicate our previous finding an independent UHR cohort, examined the relationship between these regions, psychosis depression symptoms, traumatic experiences childhood. Pseudo-Continuous Arterial Spin Labelling (p-CASL) imaging was used measure cerebral blood flow (rCBF) 77 individuals 25 healthy volunteers a...
Preclinical and human data suggest that hippocampal dysfunction plays a critical role in the onset of psychosis. Neural hyperactivity hippocampus is thought to drive an increase subcortical dopamine function through glutamatergic projections striatum.To examine association between glutamate levels individuals at clinical high risk for psychosis their subsequent outcomes.This cross-sectional study 86 30 healthy control individuals, with mean follow-up 18.5 months, was conducted November 1,...
Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and disinhibition pyramidal neurons. Recent neuroimaging studies suggest resting perfusion increased in subjects at ultra-high risk (UHR) for psychosis, but how this may related GABA concentrations unknown. The present study used a multimodal approach address issue UHR subjects. Proton magnetic resonance spectroscopy...
The brain integrates multiple scales of description, from the level cells and molecules to large-scale networks behaviour. Understanding relationships across these may be fundamental advancing understanding function in health disease. Recent neuroimaging research has shown that functional alterations are associated with schizophrenia spectrum disorders (SSD) already present young adults at clinical high-risk for psychosis (CHR-P), yet cellular molecular determinants remain unclear. Here, we...
Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms behaviors. Here, we used multimodal neuroimaging examine the relationship between regional cerebral blood flow (rCBF) striatal dopamine synthesis capacity in people at clinical high risk (CHR) for psychosis investigated its association with subsequent functional outcomes. Ninety-five participants (67 CHR 28 healthy controls) underwent arterial spin...
Abstract Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty processing investigate this model people at clinical high risk (CHR) for psychosis according their subsequent outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied...
Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the development psychotic symptoms. The aim this study was to examine relationship between glutamate and subcortical function in people at clinical high risk for psychosis, assess association with 1H-MRS used measure concentrations, 18F-DOPA PET dopamine synthesis capacity 70 subjects (51 19 healthy controls). Clinical assessments were...
<h3>Importance</h3> The development of adverse clinical outcomes in patients with psychosis has been associated behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations brain regions subserving processing remains unclear. <h3>Objective</h3> To examine regional gray matter volumes individuals at high risk (CHR) for psychosis, subsequent outcomes. <h3>Design, Setting, Participants</h3> This naturalistic case-control study follow-up 12...
Whilst robust preclinical and postmortem evidence suggests that altered GABAergic function is central to the development of psychosis, little known about whether it in subjects at ultra-high risk or its relationship prodromal symptoms.Twenty-one antipsychotic naïve individuals 20 healthy volunteers underwent proton magnetic resonance imaging 3T. Gamma-aminobutyric acid levels were obtained from medial prefrontal cortex using MEGA-PRESS expressed as peak-area ratios relative synchronously...
Negative symptoms occur early in the clinical high risk (CHR) state and indicate increased of conversion to psychotic disorder poor functional outcome. However, while negative symptom domain has shown be parsimoniously explained by a 2-factor construct schizophrenia, there yet an established factor structure CHR.214 individuals meeting Structured Interview for Psychosis-Risk Syndromes (SIPS) criteria CHR were recruited through 3 active research programs United States. Exploratory Factor...
Depersonalisation is the experience of being detached or disconnected from one's experience. Studies suggest that clinically significant levels depersonalisation are common in individuals who have psychotic symptoms and associated with increased impairment. However, to date, there been no studies investigated an intervention designed target such patient groups. This study aims determine feasibility acceptability a brief targeting those also current symptoms. The delivering six sessions...
ABSTRACT The brain integrates multiple scales of description, from the level cells and molecules to large-scale networks behaviour, understanding relationships between these layers may be fundamental advancing our how works in health disease. Recent neuroimaging research has shown that alterations function are associated with schizophrenia spectrum disorders (SSD) already present young adults at clinical high-risk for psychosis (CHR-P), yet cellular molecular determinants not well...
The last two decades have seen an exponential growth in research on people at ultra high risk (UHR) for psychosis, generating valuable new information the factors that contribute to onset of disorder1. However, most these findings were obtained from individuals who presented mental health services specialized UHR group. Because they been selected through a clinical referral process, subjects may differ also meet criteria but do not contact such services2. To date, this field has included...
Abstract Objective To examine the association between baseline alterations in grey matter volume (GMV) and clinical functional outcomes people at high risk (CHR) for psychosis. Methods 265 CHR individuals 92 healthy controls were recruited as part of a prospective multi-center study. After assessment using magnetic resonance imaging (MRI), participants followed least two years to determine outcomes, including transition psychosis (according Comprehensive Assessment an At Risk Mental State,...
Depersonalisation/derealisation symptoms are prevalent in psychosis patients, associated with increased impairment, and may maintain symptoms. We aimed to establish the feasibility acceptability of a brief, six session therapy protocol adapted from Cognitive-Behavioural model Depersonalisation-Derealisation Disorder (DDD) participants psychotic
Abstract Aim Positive symptoms are a critical dimension of psychopathology in psychotic disorders and used as criterion for diagnosis across the psychosis continuum. Although initially considered one dimension, there is evidence multidimensionality within positive symptoms. The symptom structure has not been examined individuals at clinical high risk (CHR) psychosis. Knowledge dimensional CHR may contribute to our understanding aetiology trajectory this key facet Method Exploratory factor...
Abstract Preclinical rodent models suggest that psychosis involves alterations in the activity and glutamatergic function hippocampus, driving dopamine through projections to striatum. The extent which this model applies onset of clinical subjects is unclear. We assessed whether interactions between hippocampal activity/striatal connectivity are associated with adverse outcomes people at high-risk (CHR) for psychosis. measured functional Magnetic Resonance Imaging activation/connectivity, 1...