A5087183469- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Obsessive-Compulsive Spectrum Disorders
- Diet and metabolism studies
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Parkinson's Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Autism Spectrum Disorder Research
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Diabetes and associated disorders
- Neuroscience and Neuropharmacology Research
- Eating Disorders and Behaviors
- Single-cell and spatial transcriptomics
- Epilepsy research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Prenatal Substance Exposure Effects
- Cell Image Analysis Techniques
- Suicide and Self-Harm Studies
Universidad de Cantabria
2015-2025
Marqués de Valdecilla University Hospital
2015-2025
Instituto de Investigación Marqués de Valdecilla
2015-2025
Centro de Investigación Biomédica en Red de Salud Mental
2014-2024
Instituto de Salud Carlos III
2021-2023
Abstract Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development a serum biomarker test for at risk developing schizophrenia based on multiplex immunoassay profiling analysis 957 samples. First, we conducted meta-analysis five independent cohorts 127 first-onset drug-naive patients 204 controls. Using least absolute shrinkage selection operator regression, identified an...
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Different effectiveness profiles among antipsychotics may be a key point to optimize treatment in patients suffering first episode of psychosis impact on long-term outcome. The aim this study is compare the clinical olanzapine, risperidone, haloperidol, aripiprazole, ziprasidone, and quetiapine at 3-year follow-up.From February 2001 January 2011, 2 phases prospective, randomized, open-label were undertaken. A total 376 first-episode drug-naïve randomly assigned olanzapine (n = 55),...
Abstract While sex differences in schizophrenia have long been reported and discussed, long-term outcomes among first episode of psychosis (FEP) patients terms the efficacy Early Intervention Services (EIS) has an under-explored area. A total 209 FEP (95 females 114 males) were reassessed after a time window ranging from 8 to 16 years their contact with EIS program (PAFIP) that we will call 10-year PAFIP cohort. Multiple clinical, cognitive, functioning, premorbid, sociodemographic variables...
Background Trajectory patterns of positive, disorganized and negative dimension symptoms during antipsychotic treatment in drug-naive patients with first-episode psychosis have yet to be examined by using naturalistic data. Method This pragmatic clinical trial randomized 161 a first episode olanzapine, risperidone or haloperidol. Patients were assessed the Scale for Assessment Negative Symptoms (SANS) Positive (SAPS) at baseline end weeks 1, 2, 3, 4 6 treatment. Censored normal models...
Abstract This study examines relationships between mathematical problem-solving performance (in terms of strategies used and accuracy) the main cognitive domains associated with learning (i.e. executive functions, verbal comprehension social perception) children without autism spectrum disorder (ASD non-ASD resp.). The involved 26 ASD intellectual disabilities, 6 12 years old, matched by sex, age school (grade classroom). results show a higher percentage problem solving difficulties than...
Background LAIs with longer dosing intervals appear to be associated improved clinical outcomes and added real-world benefits in the management of schizophrenia. Paliperidone palmitate six-monthly (PP6M) LAI provides longest interval, twice-yearly dosing, among all currently available LAIs. In trials PP6M was found non-inferior preventing relapses patients schizophrenia compared three monthly formulation (PP3M) though real world data remain limited. Therefore, aim this study evaluate...
Objective To examine the long‐term (up to 10 years) patterns related cannabis use in a sample of patients with first episode psychosis (FEP) and effect that consumption might have on clinical, functioning, neurocognition at long‐term. Methods Cannabis was described 209 FEP patients. Patients were divided into three groups according use: persistent users, ex‐users, never‐users. Groups longitudinally (baseline 10‐year follow‐up) compared functional, cognitive variables. Results Clinical...