A5014043242- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Estrogen and related hormone effects
- Diabetes Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Menopause: Health Impacts and Treatments
- Peripheral Artery Disease Management
- Metabolism, Diabetes, and Cancer
- Cardiac Valve Diseases and Treatments
- Bone health and osteoporosis research
- Cardiac, Anesthesia and Surgical Outcomes
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Practices
- Cardiovascular Function and Risk Factors
- Hormonal and reproductive studies
- Lipoproteins and Cardiovascular Health
- Urinary Bladder and Prostate Research
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
Eli Lilly (United States)
2011-2024
Cornwall Partnership NHS Foundation Trust
2013-2024
Eli Lilly (Singapore)
2022
Baptist Hospital
2018-2022
Saint Thomas Midtown Hospital
2018-2022
Mississippi State University
2020
Cardiovascular Research Associates
2019-2020
Brookwood Baptist Health
2019-2020
Society for Cardiovascular Angiography and Interventions
2020
Cardiovascular Research Foundation
2008-2018
Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site vascular injury may reduce incidence neointimal hyperplasia and restenosis.At 73 U.S. centers, we enrolled 1314 patients who were receiving a stent in single, previously untreated coronary-artery stenosis (vessel diameter, 2.5 3.75 mm; lesion length, 10 28 mm) prospective, randomized, double-blind study. A total 652 randomly assigned receive...
This text covers topics in algebraic geometry and commutative algebra with a strong perspective toward practical computational aspects. The first four chapters form the core of book. A comprehensive chart Preface illustrates variety ways to proceed material once these are covered. In addition fundamentals geometrythe elimination theorem, extension closure theorem Nullstellensatzthis new edition incorporates several substantial changes, all which listed Preface. largest revision Chapter...
Current guidelines for patients with moderate- or high-risk acute coronary syndromes recommend an early invasive approach concomitant antithrombotic therapy, including aspirin, clopidogrel, unfractionated low-molecular-weight heparin, and glycoprotein IIb/IIIa inhibitors. We evaluated the role of thrombin-specific anticoagulation bivalirudin in such patients.We assigned 13,819 to one three regimens: heparin enoxaparin plus a inhibitor, alone. The primary end points were composite ischemia...
As compared with thrombolytic therapy, primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction reduces the rates of death, reinfarction, and stroke, but recurrent ischemia, restenosis, reocclusion infarct-related artery remain problematic. When used combination PTCA, stenting platelet glycoprotein IIb/IIIa inhibitors may further improve outcomes.
Coronary-stent implantation is frequently performed for treatment of acute myocardial infarction. However, few studies have compared stent with primary angioplasty alone.We designed a multicenter study to compare accompanied by heparin-coated Palmaz-Schatz stent. Patients infarction underwent emergency catheterization and angioplasty. Those vessels suitable stenting were randomly assigned undergo (452 patients) or alone (448 patients).The mean (+/-SD) minimal luminal diameter was larger...
The safety and efficacy of the slow-release, polymer-based, paclitaxel-eluting stent after implantation in a broad cross section de novo coronary lesions at 1 year are unknown.In TAXUS-IV trial, 1314 patients with single 10 to 28 mm length, reference-vessel diameter 2.5 3.75 mm, coverable by study stent, were prospectively randomized TAXUS or an identical-appearing bare-metal EXPRESS stent. By actuarial analysis, compared reduced 12-month rates target-lesion revascularization 73% (4.4%...
Vitamin D deficiency leads to secondary hyperparathyroidism, increased bone turnover, and loss and, when severe, osteomalacia. is common in elderly people, especially the institutionalized. The definition of vitamin hampered by fact that large interlaboratory differences exist assays for serum 25-hydroxyvitamin (25OHD), main circulating metabolite. international Multiple Outcomes Raloxifene Evaluation study, a prospective intervention trial postmenopausal women with osteoporosis, offered...
ContextRaloxifene, a selective estrogen receptor modulator, improves cardiovascular risk factors, but its effect on events is unknown.ObjectiveTo determine the of raloxifene in osteoporotic postmenopausal women.DesignSecondary analysis data from Multiple Outcomes Raloxifene Evaluation trial, randomized, double-blind, placebo-controlled trial conducted between November 1994 and September 1999.SettingOutpatient community settings at 180 sites 25 countries.ParticipantsA total 7705 women (mean...
In the placebo group of MORE study, including 2576 postmenopausal women (mean age, 66.5 years), authors describe a strong linear association between severity grade osteoporosis (from low BMD to presence severe vertebral fractures) and future risk cardiovascular events. Accordingly, treatment should include consideration measures prevent adverse outcomes.Observations indicate an inverse peripheral atherosclerosis in women. The predictive value its different stages for acute events remains...
R emarkable progress in the percutaneous management of coronary artery disease has been achieved over last decade.The scaffolding properties stents have resulted intervention (PCI) becoming a predictable procedure, with reduced rates acute closure and late restenosis compared balloon angioplasty alone. 1,2More recently, site-specific delivery antiproliferative agents from drug-eluting demonstrated to markedly attenuate vascular responses leading neointimal hyperplasia, further reducing...
Background — Whereas survival after lytic therapy for myocardial infarction is strongly dependent on early administration, it unknown whether the otherwise excellent outcomes in patients undergoing primary PTCA acute infarction, whom TIMI-3 flow rates of >90% may be achieved, can further improved by reperfusion. Methods and Results Among 2507 enrolled 4 PAMI trials PTCA, spontaneous reperfusion (TIMI-3 flow) was present 16% at initial angiography. Compared with without flow, those before...
Dilator reserve of the coronary microvasculature is diminished in patients with dilated cardiomyopathy. Although increased extravascular compressive forces, tachycardia, and myocardial mass can explain some impairment, recent evidence suggests possibility intrinsic microvascular disease. We tested hypothesis that impairment endothelium-dependent dilation could be a contributing mechanism. infused dilator acetylcholine (Ach) (10(-8) to 10(-6) M) smooth muscle vasodilator adenosine (AD)...
FROM FERMAT TO GAUSS. Fermat, Euler and Quadratic Reciprocity. Lagrange, Legendre Forms. Gauss, Composition Genera. Cubic Biquadratic CLASS FIELD THEORY. The Hilbert Class Field p = x 2 + ny . Genus Theory. Orders in Imaginary Fields. Fields Theory the Cebotarev Density Theorem. Ring COMPLEX MULTIPLICATION. Elliptic Functions Complex Multiplication. Modular Singular j--Invariants. Equation. Ellpitic Curves. References. Index.
Studies in animals have suggested that increases blood flow result dilation of large arteries by an endothelium-dependent mechanism. Atherosclerosis can impair vasodilation to vasoactive agents. The purpose this study was determine whether or not coronary humans exhibit with and test the hypothesis response is impaired presence atherosclerosis. Graded concentrations adenosine were infused into distal left anterior descending (LAD) artery dilator proximal LAD flow. thereby exposed changes...
The prognostic importance of renal insufficiency (RI) in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) has not been well characterized.PCI was performed 2082 AMI without shock presenting within 12 hours symptom onset a prospective, multicenter randomized trial. RI defined as calculated (Cockroft-Gault) creatinine clearance (CrCl) < or =60 mL/min. at baseline present 18% patients. Compared with RI, were older and more likely to be...
The high rate of periprocedural complications resulting from atherothrombotic embolization after percutaneous intervention in diseased saphenous vein grafts is reduced by distal microcirculatory protection using a balloon occlusion and aspiration system. Whether filter-based catheters, which offer the inherent advantages maintained perfusion ease use, are as effective for this purpose has not been established.A total 651 patients undergoing 682 graft lesions were prospectively randomized to...
Background— Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS is associated with improved clinical outcomes after drug-eluting stent (DES) implantation an unrestricted patient population unknown. Methods and Results— Assessment Dual Antiplatelet Therapy With Drug-Eluting Stents (ADAPT-DES) was prospective, multicenter, nonrandomized “all-comers” study 8583 consecutive patients at 11 international centers...
ContextIn patients with moderate- and high-risk acute coronary syndromes (ACS) who undergo an early, invasive treatment strategy, current guidelines recommend administration of platelet glycoprotein IIb/IIIa (Gp IIb/IIIa) inhibitors, either upstream to all prior angiography or deferred for selective use in the catheterization laboratory just angioplasty. The preferred approach is undetermined.ObjectiveTo determine optimal strategy Gp inhibitors ACS undergoing strategy.DesignProspective,...
OBJECTIVE To compare efficacy and safety of dulaglutide at doses 3.0 4.5 mg versus 1.5 in patients with type 2 diabetes inadequately controlled metformin. RESEARCH DESIGN AND METHODS Patients were randomly assigned to once-weekly mg, or for 52 weeks. The primary objective was determining superiority and/or over HbA1c reduction 36 Secondary objectives included change body weight. Two estimands addressed objectives: treatment regimen (regardless discontinuation rescue medication) (on without...