A5088981482- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Inflammatory Bowel Disease
- Microscopic Colitis
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Practices and Rehabilitation
- Iron Metabolism and Disorders
- Cardiac Ischemia and Reperfusion
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Lymphoma Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Aortic aneurysm repair treatments
- Forest Ecology and Biodiversity Studies
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Pregnancy and Medication Impact
Agaplesion Frankfurter Diakonie Kliniken
2023
Sana Klinikum
2017-2021
Agaplesion Markus Hospital
2017-2018
St. Elisabethen-Krankenhaus Frankfurt
2011-2015
Marienkrankenhaus Hamburg
1991-2013
Marienhospital Stuttgart
2012
Crohn's and Colitis UK
2012
University Hospital Schleswig-Holstein
2004-2011
University of Lübeck
2002-2011
Foundation of Cardiac Surgery Development
2011
Treatment with the direct thrombin inhibitor bivalirudin, as compared heparin plus glycoprotein IIb/IIIa inhibitors, results in similar suppression of ischemia while reducing hemorrhagic complications patients stable angina and non-ST-segment elevation acute coronary syndromes who are undergoing percutaneous intervention (PCI). The safety efficacy bivalirudin high-risk unknown.We randomly assigned 3602 ST-segment myocardial infarction presented within 12 hours after onset symptoms were...
ContextIn patients with moderate- and high-risk acute coronary syndromes (ACS) who undergo an early, invasive treatment strategy, current guidelines recommend administration of platelet glycoprotein IIb/IIIa (Gp IIb/IIIa) inhibitors, either upstream to all prior angiography or deferred for selective use in the catheterization laboratory just angioplasty. The preferred approach is undetermined.ObjectiveTo determine optimal strategy Gp inhibitors ACS undergoing strategy.DesignProspective,...
The utility of N-terminal proBNP (NT-proBNP) to predict the occurrence death and hospitalization was prospectively evaluated in COPERNICUS study, which enrolled patients with an ejection fraction <25% symptoms chronic congestive heart failure at rest or on minimal exertion.Baseline plasma concentrations NT-proBNP were measured a subgroup 814 men 197 women exertion who study randomized placebo (n=506) carvedilol (n=505). Values markedly increased despite requirement that be euvolemic before...
Background Vedolizumab, a monoclonal antibody targeting the α4β7-integrin, is effective in inducing and maintaining clinical remission Crohn's disease ulcerative colitis according to randomised trials. Aim To determine long-term effectiveness of vedolizumab real-world setting. Methods This observational registry assessed outcome patients treated with for clinically active (n = 67) or 60). Primary endpoint was (HBI ≤ 4/pMayo 1) at week 54. Secondary endpoints included response rates...
Background —In contrast to healthy volunteers, regional differences of cardiac autonomic innervation have been described through the use C 11 -hydroxyephedrine positron emission tomography (HED-PET) in left ventricles patients with dilated cardiomyopathy. The goal present study was correlate HED-PET images biochemical analysis tissue samples. Methods and Results —To assess significance altered HED uptake, we used examine eight cardiomyopathy before heart transplantation. After explantation,...
Background — In ST-segment elevation myocardial infarction, a troponin T ≥0.1 μg/L on admission indicates poorer prognosis despite early reperfusion. To evaluate the underlying reason, we studied value of cardiac (cTnT) for prediction outcomes, epicardial blood flow, and reperfusion after primary percutaneous intervention. Methods Results Patients (n=140) admitted within 12 hours onset symptoms were stratified by cTnT. Epicardial graded TIMI score measurement relative increases myoglobin,...
<h3>OBJECTIVE</h3> To assess presynaptic function of cardiac autonomic innervation in patients with advanced congestive heart failure using positron emission tomography (PET) and the recently developed radiolabelled catecholamine analogue carbon-11 hydroxyephedrine (HED) as a marker for neuronal uptake function. <h3>DESIGN AND PATIENTS</h3> 29 suffering from dilated cardiomyopathy moderate to severe were compared eight healthy controls. Perfusion scan was followed by HED dynamic PET imaging...
Therapy for active left-sided ulcerative colitis usually involves topical application of mesalazine (mesalamine) or budesonide.To compare the efficacy and safety budesonide enema in treatment colitis.A total 237 patients with mild-moderate were randomized open 1:1 to receive either (n = 118) enemas 119) 8 weeks. Efficacy variables clinical activity index, endoscopic, histological index IBDQ scores after 4 weeks.Clinical remission (intention-to-treat analysis) at week was 63.5% 77.2% (P <...
The introduction of immunosuppressants and biologic agents has led to active debate research about optimal therapeutic strategies considering risk factors predictors clinical outcome in inflammatory bowel disease (IBD). Data gender-specific treatment differences is lacking for IBD. aim the present study was evaluate gender-related a distinct IBD patient population treated Rhein-Main region, Germany.Data past medical history, status 986 outpatients ten gastroenterological practices three...
We assessed the impact of early infarct-related artery (IRA) recanalisation on outcomes patients in recently conducted, large-scale, multicentre HORIZONS-AMI trial.Of 3,602 enrolled trial, 3,093 (85.9%) were treated with percutaneous coronary intervention (PCI) to a single artery. analysed one-year these according presence or absence IRA patency, defined as Thrombolysis Myocardial Infarction (TIMI) 2 3 flow IRA. Baseline angiography showed patency 1,121 (36.2%), while 1,972 (63.8%) had TIMI...
Background: Vedolizumab (VDZ) drug monitoring strategies in inflammatory bowel disease (IBD) patients have not been systematically investigated so far. We evaluated the correlation between VDZ trough levels (VTL) and treatment response IBD.Methods: Fifty-one with active IBD on or starting a therapy were enrolled this prospective observational single centre study. Disease activity indices, blood tests, anthropometric parameters assessed over time period of 6 months. One hundred fifty-five...
Abnormal heart rate turbulence (HRT) is associated with an increased risk of mortality in the chronic phase myocardial infarction (MI) prethrombolytic and thrombolytic eras. However, impact direct percutaneous coronary intervention (PCI) on HRT acute MI its association to epicardial infarct-related arterial flow has not been examined.We investigated 126 patients undergoing PCI for a first MI. Turbulence onset slope were determined before reperfusion, during initial 2 hours after 6 24...