A5088932937- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Neuroblastoma Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Epilepsy research and treatment
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Neuroendocrine Tumor Research Advances
- Long-Term Effects of COVID-19
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Statistical Methods in Clinical Trials
- Hematological disorders and diagnostics
- COVID-19 and Mental Health
- Connective tissue disorders research
University Medical Center Utrecht
2019-2025
Utrecht University
2004-2025
Princess Máxima Center
2021-2024
Heidelberg University
2020-2023
University Hospital Heidelberg
2020-2023
University Medical Center Groningen
2023
University Medical Center
2023
Wilhelmina Children's Hospital
2020-2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2006-2018
General Department of Preventive Medicine
2011-2018
A major pathological hallmark of Alzheimer's disease is accumulation amyloid-β in senile plaques the brain. Evidence accumulating that decreased clearance from brain may lead to these elevated levels. One pathways transport across blood–brain barrier via efflux transporters. P-glycoprotein, an pump highly expressed at endothelial cells barrier, has been shown amyloid-β. P-glycoprotein function can be assessed vivo using (R)-[11C]verapamil and positron emission tomography. The aim this study...
The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements β-amyloid-1–42 (Aβ<sub>1-42</sub>) and total tau <sup>11</sup>C-Pittsburgh compound B (<sup>11</sup>C-PiB) 2-(1-{6-[(2-<sup>18</sup>F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile (<sup>18</sup>F-FDDNP) binding as measured using PET. <b>Methods:</b> A 37 subjects were included, consisting 15 patients with Alzheimer disease (AD), 12 mild cognitive...
Several methods are in use for analyzing <sup>11</sup>C-Pittsburgh compound-B (<sup>11</sup>C-PiB) data. The objective of this study was to identify the method choice measuring longitudinal changes specific <sup>11</sup>C-PiB binding. <b>Methods:</b> Dynamic 90-min baseline and follow-up scans (interval, 30 ± 5 mo) were obtained 7 Alzheimer disease (AD) patients, 11 patients with mild cognitive impairment (MCI), healthy controls. Parametric images generated using reference parametric mapping...
Alzheimer's disease with early onset often presents a distinct cognitive profile, potentially reflecting different distribution of underlying neuropathology. The purpose this study was to examine the relationships between age and both in vivo fibrillary amyloid deposition glucose metabolism patients disease. Dynamic [11C]Pittsburgh compound-B (90 min) static [18F]fluorodeoxyglucose (15 scans were obtained 100 20 healthy controls. Parametric non-displaceable binding potential images...
To provide practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor (SSTR) ligands. This joint standard was collaboratively developed by the European Association Nuclear Medicine (EANM), Society Molecular Imaging (SNMMI), Neurooncology (EANO), PET task force Response Assessment in Working Group (PET/RANO). Positron emission tomography (PET) ligands can detect meningioma tissue with high sensitivity specificity...
Abstract Epilepsy is one of the most frequent neurological conditions with an estimated prevalence more than 50 million people worldwide and annual incidence two million. Although pharmacotherapy anti-seizure medication (ASM) treatment choice, ~30% patients epilepsy do not respond to ASM become drug resistant. Focal form epilepsy. In drug-resistant focal epilepsy, surgery a option depending on localisation seizure focus for relief or freedom consecutive improvement in quality life. Beside...
This joint practice guideline/procedure standard was collaboratively developed by the European Association of Nuclear Medicine (EANM), Society and Molecular Imaging (SNMMI), Neuro-Oncology (EANO), PET task force Response Assessment in Neurooncology Working Group (PET/RANO). Brain metastases are most common malignant central nervous system (CNS) tumors. imaging with radiolabeled amino acids to lesser extent [18F]FDG has gained considerable importance assessment brain metastases, especially...
<sup>11</sup>C-Pittsburgh Compound-B (<sup>11</sup>C-PIB) and <sup>18</sup>F-(2-(1-{6-[(2-[<sup>18</sup>F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) (<sup>18</sup>F-FDDNP) have been developed as PET tracers for in vivo imaging of pathology Alzheimer9s disease (AD). The purpose this study was to directly compare these patients with AD, mild cognitive impairment (MCI), healthy controls. <b>Methods:</b> Paired <sup>11</sup>C-PIB <sup>18</sup>F-FDDNP scans were acquired 14 11 amnestic...
Appropriate imaging is essential in the treatment of children and adolescents with rhabdomyosarcoma. For adequate stratification optimal individualised local utilising surgery radiotherapy, high-quality crucial. The paediatric radiologist, therefore, an member multi-disciplinary team providing clinical care research. This manuscript presents European rhabdomyosarcoma guideline, based on recently developed guideline Paediatric Soft Tissue Sarcoma Study Group (EpSSG) Imaging Committee. was...
Summary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology long COVID is unknown. Here we present in-vivo evidence widespread neuroinflammation in COVID, using quantitative assessment, [ 18 F]DPA-714 PET, two patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both with had increases binding throughout the brain....
Abstract Purpose Meta -[ 18 F]fluorobenzylguanidine ([ F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates feasibility [ F]mFBG PET-CT in neuroblastoma. Methods In prospective, single-centre study, we recruited children with neuroblastoma, referred meta 123 I]iodobenzylguanidine I]mIBG) scanning, consisting total body planar scintigraphy combination...
Abstract Background Accurate image-derived input function (IDIF) from highly sensitive large axial field of view (LAFOV) PET/CT scanners could avoid the need invasive blood sampling for kinetic modelling. The aim is to validate use IDIF two kinds tracers, 3 different locations and 9 reconstruction settings. Methods Eight [ 18 F]FDG 10 F]DPA-714 scans were acquired respectively during 70 60 min on Vision Quadra system. PET images reconstructed using various IDIFs taken ascending aorta (AA),...
Measuring total metabolic tumor volume (TMTV) on <sup>18</sup>F-FDG PET/CT images in clinical practice requires a fast, reliable, and easy-to-perform multilesional segmentation workflow. We conducted field test to derive volumes using 5 representative baseline scans from patients with diffuse large B-cell lymphoma. The were transferred 10 different sites or readers who used commercially available software platforms TMTV after recently proposed benchmark Observed TMTVs compared reference...
The aim of this study was to assess the test-retest variability [11C]PIB studies in patients with Alzheimer’s disease (AD) and healthy controls using several tracer kinetic models suitability cerebellum as reference tissue. arterial sampling were performed eight AD controls. Retest scans six patients. Data analysed plasma input tissue models, together simple ratios. Test-retest best (∼3%) for SRTM2, a parametric method based on simplified model. Highest values (∼10%) found models. Cerebellar...