Roelof van Ewijk
A5089994063- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Surgical site infection prevention
- Soft tissue tumor case studies
- Tumors and Oncological Cases
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Burn Injury Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Bone Tumor Diagnosis and Treatments
- Sirtuins and Resveratrol in Medicine
- COVID-19 and healthcare impacts
- Fungal Infections and Studies
- Neonatal and fetal brain pathology
- Diversity and Career in Medicine
- Adipose Tissue and Metabolism
- Skin Protection and Aging
- Testicular diseases and treatments
- Neurofibromatosis and Schwannoma Cases
- Healthcare Systems and Public Health
- Orthopedic Infections and Treatments
- Contact Dermatitis and Allergies
- Antifungal resistance and susceptibility
Princess Máxima Center
2021-2025
University Medical Center Utrecht
2022
University of Amsterdam
2021
Emma Kinderziekenhuis
2021
Amsterdam University Medical Centers
2021
St. Elisabeth Hospital
2021
The University of Melbourne
2017
Sint Lucas Andreas Hospital
2012
Amsterdam UMC Location Vrije Universiteit Amsterdam
2011
The Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children adults with rhabdomyosarcoma (RMS). trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design focus on (i) novel regimens poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, (iii) use radiotherapy local control widespread metastatic disease. Additional...
Appropriate imaging is essential in the treatment of children and adolescents with rhabdomyosarcoma. For adequate stratification optimal individualised local utilising surgery radiotherapy, high-quality crucial. The paediatric radiologist, therefore, an member multi-disciplinary team providing clinical care research. This manuscript presents European rhabdomyosarcoma guideline, based on recently developed guideline Paediatric Soft Tissue Sarcoma Study Group (EpSSG) Imaging Committee. was...
Osteosarcoma and Ewing sarcoma are bone tumors mostly diagnosed in children, adolescents, young adults. Despite multimodal therapy, morbidity is high survival rates remain low, especially the metastatic disease setting. Trials investigating targeted therapies immunotherapies have not been groundbreaking. Better understanding of biological subgroups, role tumor immune microenvironment, factors that promote metastasis, clinical biomarkers prognosis drug response required to make progress. A...
ABSTRACT Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal reduce subsequent recurrences. However, differences lymph node strategies, definitions, treatment protocols between Children's Oncology Group (COG), European paediatric Soft tissue Study (E p SSG), Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim establish internationally recognized...
Abstract Objective To investigate the prognostic value of baseline European Association Nuclear Medicine Research Ltd. (EARL) standardized [ 18 F]fluorodeoxyglucose positron emission tomography-computed tomography ([ F]FDG PET-CT) quantitative values for survival and to evaluate cutoff identified in other studies. Materials methods Pediatric adolescent patients with high-grade osteosarcoma were included. Baseline PET-CT, EARL-accredited reconstructions, was standard diagnostic staging...
Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site body, with common presentations head neck, genitourinary tract extremities. The optimal diagnostic approach management of rhabdomyosarcoma require multidisciplinary team multimodal treatment, including chemotherapy local therapy. Survival has improved over last decades; however, further improvement essential current 5-year overall survival ranging...
Osteosarcoma is a challenging disease requiring multidisciplinary management in expert centers for optimal outcome. There are no current international protocols or guidelines specific pediatric and adolescent osteosarcoma. The European Standard Clinical Practice (ESCP) project collaboration between ERN PaedCan SIOP Europe's Trial Groups to develop approved clinical recommendations reflecting best practice. This manuscript summary of the full ESCP guideline patients with provides evidence...
Solid tumors account for about 30% of all pediatric cancers. The diagnosis is typically based on histological and molecular analysis a primary tumor biopsy. Liquid biopsies carry several advantages over conventional tissue However, their use genomic response monitoring solid still in experimental stages mostly performed retrospectively without direct impact patient management. In this case series we discuss six clinical cases children with whom liquid biopsy assay was demonstrate the...
To determine the effect of Scriptaid, a compound that can replicate aspects exercise adaptive response through disruption class IIa histone deacetylase (HDAC) corepressor complex, on muscle insulin action in obesity.Diet-induced obese mice were administered Scriptaid (1 mg/kg) via daily intraperitoneal injection for 4 weeks. Whole-body and skeletal metabolic phenotyping was performed, addition to echocardiography, assess cardiac morphology function.Scriptaid treatment had no body weight or...
Abstract Background Perinatally chikungunya infected neonates have been reported to high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults does not appear but data on postnatally infants are lacking. Methods We performed a prospective, non-controlled, observational study before the age 6 months with severe infection during 2014–2015 epidemic in Curaçao, Dutch Antilles. Two years motor - (BSID-III) social emotional assessments (ITSEA) were...
The COVID-19 pandemic onset had a global debilitating impact on individuals and burgeoning careers. In 2021, the Children's Oncology Group Young Investigators Committee, SIOP (International Society of Paediatric Oncology) Network, SIOPE (European for co-sponsored survey to explore impacts first year early-career pediatric oncology professionals with respect working practices, productivity, professional career development, personal wellbeing, changing childcare needs.
To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma.We performed multicenter retrospective study including pediatric, adolescent and young adult rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to European paediatric Soft tissue sarcoma Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was institutional protocols. We two-dimensional...